Výsledky vyhledávání - "S, Sutterwala"

Akademický článek

TBK1 and GABARAP family members suppress Coxsackievirus B infection by limiting viral production and promoting autophagic degradation of viral extracellular vesicles.

Autor: Savannah Sawaged, Thomas Mota, Honit Piplani, Reetu Thakur, Deepti Lall, Elizabeth McCabe, Soojung Seo, Fayyaz S Sutterwala, Ralph Feuer, Roberta A Gottlieb, Jon Sin

Publikováno v: PLoS Pathogens, Vol 18, Iss 8, p e1010350 (2022)

Host-pathogen dynamics are constantly at play during enteroviral infection. Coxsackievirus B (CVB) is a common juvenile enterovirus that infects multiple organs and drives inflammatory diseases including acute pancreatitis and myocarditis. Much like

Externí odkaz: https://doaj.org/article/e696c9c12bf5439ba9dabcd41437eaa3

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Akademický článek

Coinfection with Leishmania major and Staphylococcus aureus enhances the pathologic responses to both microbes through a pathway involving IL-17A.

Autor: Tiffany Y Borbón, Breanna M Scorza, Gwendolyn M Clay, Fellipe Lima Nobre de Queiroz, Alan J Sariol, Jayden L Bowen, Yani Chen, Bayan Zhanbolat, Corey P Parlet, Diogo G Valadares, Suzanne L Cassel, William M Nauseef, Alexander R Horswill, Fayyaz S Sutterwala, Mary E Wilson

Publikováno v: PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007247 (2019)

Cutaneous leishmaniasis (CL) is a parasitic disease causing chronic, ulcerating skin lesions. Most humans infected with the causative Leishmania protozoa are asymptomatic. Leishmania spp. are usually introduced by sand flies into the dermis of mammal

Externí odkaz: https://doaj.org/article/d356486971d14c3ab0729d9b3e40b87f

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Akademický článek

Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment

Autor: Tyler K. Ulland, Nidhi Jain, Emma E. Hornick, Eric I. Elliott, Gwendolyn M. Clay, Jeffrey J. Sadler, Kathleen A. M. Mills, Ann M. Janowski, A. Paige Davis Volk, Kai Wang, Kevin L. Legge, Lokesh Gakhar, Mohammed Bourdi, Polly J. Ferguson, Mary E. Wilson, Suzanne L. Cassel, Fayyaz S. Sutterwala

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

The role of NLRP12 in immunity to bacterial infection is controversial as varied and contrasting results have been published using C57BL/6 mice. Here the authors shed light on this issue, showing that unlike C57BL/6N mice, C57BL/6J mice have a missen

Externí odkaz: https://doaj.org/article/383567b1d23c49cca2e3d2f968f86070

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Akademický článek

Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

Autor: Ryan Kolb, Liem Phan, Nicholas Borcherding, Yinghong Liu, Fang Yuan, Ann M. Janowski, Qing Xie, Kathleen R. Markan, Wei Li, Matthew J. Potthoff, Enrique Fuentes-Mattei, Lesley G. Ellies, C. Michael Knudson, Mong-Hong Lee, Sai-Ching J. Yeung, Suzanne L. Cassel, Fayyaz S. Sutterwala, Weizhou Zhang

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

Obesity is associated with higher breast cancer risk and poor prognosis. Here, the authors show that obesity promotes breast cancer through the recruitment of macrophages with activated NLRC4 inflammasome, which activate IL-1β production, resulting

Externí odkaz: https://doaj.org/article/8dc39d9da6c541818c16001eb4cc7191

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The Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model

Autor: Kierra S. Hardy, Amanda N. Tuckey, Nicole A. Housley, Joel Andrews, Mita Patel, Abu-Bakr Al-Mehdi, Robert A. Barrington, Suzanne L. Cassel, Fayyaz S. Sutterwala, Jonathon P. Audia

Publikováno v: Infection and Immunity. 90

Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes nosocomial pneumonia, urinary tract infections, and bacteremia. A hallmark of P. aeruginosa pathogenesis is disruption of host cell function by the type III secretion syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd1ad95b27819f55465138bff58deb6
https://doi.org/10.1128/iai.00470-21

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Akademický článek

The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.

Autor: Xiaowei Wang, Dana K Shaw, Holly L Hammond, Fayyaz S Sutterwala, Manira Rayamajhi, Kari Ann Shirey, Darren J Perkins, Joseph V Bonventre, Thangam S Velayutham, Sean M Evans, Kyle G Rodino, Lauren VieBrock, Karen M Scanlon, Nicholas H Carbonetti, Jason A Carlyon, Edward A Miao, Jere W McBride, Michail Kotsyfakis, Joao H F Pedra

Publikováno v: PLoS Pathogens, Vol 12, Iss 8, p e1005803 (2016)

Rickettsial agents are sensed by pattern recognition receptors but lack pathogen-associated molecular patterns commonly observed in facultative intracellular bacteria. Due to these molecular features, the order Rickettsiales can be used to uncover br

Externí odkaz: https://doaj.org/article/130f8b62410e47cdafb35a596bcc86c1

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Akademický článek

Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo.

Autor: Ceren Ciraci, John R Janczy, Nidhi Jain, Stefanie Haasken, Cyntia Pecli E Silva, Claudia F Benjamim, Jeffrey J Sadler, Alicia K Olivier, Yoichiro Iwakura, Dmitry M Shayakhmetov, Fayyaz S Sutterwala, Suzanne L Cassel

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151252 (2016)

The precise context in which the innate immune system is activated plays a pivotal role in the subsequent instruction of CD4+ T helper (Th) cell responses. Th1 responses are downregulated when antigen is encountered in the presence of antigen-IgG imm

Externí odkaz: https://doaj.org/article/5657ace81c584fdfa921b08750bbdbe3

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Akademický článek

Involvement of the NLRC4-Inflammasome in Diabetic Nephropathy.

Autor: Fang Yuan, Ryan Kolb, Gaurav Pandey, Wei Li, Lin Sun, Fuyou Liu, Fayyaz S Sutterwala, Yinghong Liu, Weizhou Zhang

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164135 (2016)

Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease worldwide but current treatments remain suboptimal. The role of inflammation in DN has only recently been recognized. It has been shown that the NLRP3-inflammasome contributes

Externí odkaz: https://doaj.org/article/88115779a2c74d66bd7355e24dc9c373

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