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Autor:
Bradley S. Stolshek, S. Siddhanti, Irene Ferreira, David L. Kendler, P.R. Ho, Stuart L. Silverman, Deborah T. Gold, Christine Simonelli, Alexandra Papaioannou, A. Balasubramanian, C. Recknor, D. Belazi, E. M. Lewiecki, Jacques P. Brown, Ethel S. Siris, P. Dakin
Publikováno v:
Osteoporosis International
Summary To determine persistence with subcutaneous denosumab every 6 months in women being treated for osteoporosis, we conducted a single-arm prospective, observational study in the United States and Canada. Among 935 patients enrolled, 12-month per
Autor:
Claus Christiansen, S. Siddhanti, Nathalie Franchimont, Mary S. Anthony, Nadia Daizadeh, Luanda Grazette, Elizabeth J. Samelson, Ogo Egbuna, Douglas P. Kiel, Andrea Wang, Paul D. Miller, Angela M. Cheung
Publikováno v:
Journal of Bone and Mineral Research. 29:450-457
Atherosclerosis and osteoporosis are chronic diseases that progress with age, and studies suggest aortic calcification, an indicator of atherosclerosis, is inversely associated with BMD. The OPG/RANK/RANKL system has been proposed as a shared regulat
Autor:
Irene Ferreira, M. Micaelo, S. Siddhanti, John D. Wark, M. Stone, Nikolaos Papaioannou, Lorenz C. Hofbauer, Jacques P. Brown, C. Roux, Astrid Fahrleitner-Pammer, M. C. Zillikens, P.R. Ho, Rachel B. Wagman, Federico Hawkins, Salvatore Minisola
Publikováno v:
Bone, 58, 48-54. Elsevier Inc.
Denosumab has been shown to reduce new vertebral, nonvertebral, and hip fractures in postmenopausal women with osteoporosis. In subjects who were treatment-naive or previously treated with alendronate, denosumab was associated with greater gains in b
Autor:
D L, Kendler, M R, McClung, N, Freemantle, M, Lillestol, A H, Moffett, J, Borenstein, S, Satram-Hoang, Y-C, Yang, P, Kaur, D, Macarios, S, Siddhanti, Jerieta, Waltin-James
Publikováno v:
Osteoporosis International. 22:1725-1735
In this study, 250 women with osteoporosis were randomized to 12 months with subcutaneous denosumab 60 mg every 6 months or oral alendronate 70 mg once weekly, then crossed over to the other treatment. The primary endpoint, treatment adherence at 12
Autor:
C.K. Daniels, Alex W. K. Chan, M.J. Minski, Solomon W. Leung, S. Siddhanti, B. Williams, James C. K. Lai
Publikováno v:
Procedia Environmental Sciences. 2:92-97
The intake and concentration of metals and electrolytes from our diet are believed to be affecting our general health, in particular, the proper functions of vital organs. For example, in addition to other genetic and environmental factors, consuming
Autor:
Christian Roux, Claude Laurent Benhamou, S. Siddhanti, Javier San Martin, David L. Kendler, Henry G. Bone, Hoi-Shen Man, Jacques P. Brown, M. Lillestol
Publikováno v:
Journal of Bone and Mineral Research. 25:72-81
Patients treated with bisphosphonates for osteoporosis may discontinue or require a switch to other therapies. Denosumab binds to RANKL and is a potent inhibitor of bone resorption that has been shown to increase bone mineral density (BMD) and decrea
Autor:
L. Bessette, S. F. Varon, Rachel B. Wagman, D. Macarios, David L. Kendler, Henry G. Bone, C. D. Hill, H.-S. Man, Rob Horne, Jeffrey T. Borenstein, H. Wang, S. Siddhanti, Deborah T. Gold
Publikováno v:
Osteoporosis International. 21:837-846
The Preference and Satisfaction Questionnaire (PSQ) compares patient preference and satisfaction between a 6-month subcutaneous injection and weekly oral tablet for treatment of bone loss. Patients preferred and were more satisfied with a treatment t
Autor:
S. Siddhanti, Michael A. Bolognese, Lorraine A. Fitzpatrick, Michael R. McClung, Yu Liu, Paul D. Miller, E. Michael Lewiecki, Stanley Cohen, Andrea Wang
Publikováno v:
Journal of Bone and Mineral Research. 22:1832-1841
Denosumab is a monoclonal antibody to RANKL. In this randomized, placebo-controlled study of 412 postmenopausal women with low BMD, subcutaneous denosumab given every 3 or 6 mo was well tolerated, increased BMD, and decreased bone resorption markers
Autor:
S. Siddhanti, Henry G. Bone, E. Michael Lewiecki, Roland Chapurlat, Edward Czerwiński, Bente L. Langdahl, Alan Kivitz, Ugis Gruntmanis, Bo Abrahamsen, P.R. Ho, Michael R. McClung, Rachel B. Wagman, Y.-C. Yang, Faisal M. Mirza, Michael A. Bolognese, Östen Ljunggren, Christence S. Teglbjaerg, Jean-Yves Reginster, David L. Kendler, Eric S. Orwoll, Paul D. Miller
Publikováno v:
Langdahl, B L, Teglbjaerg, C S, Ho, P-R, Chapurlat, R, Czerwinski, E, Kendler, D L, Reginster, J-Y, Kivitz, A, Lewiecki, E M, Miller, P D, Bolognese, M A, McClung, M R, Bone, H G, Ljunggren, Ö, Abrahamsen, B, Gruntmanis, U, Yang, Y-C, Wagman, R B, Mirza, F, Siddhanti, S & Orwoll, E 2015, ' A 24-month Study Evaluating the Efficacy and Safety of Denosumab for the Treatment of Men With Low Bone Mineral Density : Results From the ADAMO Trial ', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 4, pp. 1335–1342 . https://doi.org/10.1210/jc.2014-4079
Langdahl, B L, Teglbjaerg, C S, Ho, P-R, Chapurlat, R, Czerwinski, E, Kendler, D L, Reginster, J-Y, Kivitz, A, Lewiecki, E M, Miller, P D, Bolognese, M A, McClung, M R, Bone, H G, Ljunggren, Ö, Abrahamsen, B, Gruntmanis, U, Yang, Y-C, Wagman, R B, Mirza, F, Siddhanti, S & Orwoll, E 2015, ' A 24-month Study Evaluating the Efficacy and Safety of Denosumab for the Treatment of Men With Low Bone Mineral Density : Results From the ADAMO Trial ', Journal of Clinical Endocrinology and Metabolism, pp. jc20144079 . https://doi.org/10.1210/jc.2014-4079
Langdahl, B L, Teglbjaerg, C S, Ho, P-R, Chapurlat, R, Czerwinski, E, Kendler, D L, Reginster, J-Y, Kivitz, A, Lewiecki, E M, Miller, P D, Bolognese, M A, McClung, M R, Bone, H G, Ljunggren, Ö, Abrahamsen, B, Gruntmanis, U, Yang, Y-C, Wagman, R B, Mirza, F, Siddhanti, S & Orwoll, E 2015, ' A 24-month Study Evaluating the Efficacy and Safety of Denosumab for the Treatment of Men With Low Bone Mineral Density : Results From the ADAMO Trial ', Journal of Clinical Endocrinology and Metabolism, pp. jc20144079 . https://doi.org/10.1210/jc.2014-4079
Context: One in 4 men in the United States aged >50 years will have an osteoporosis-related fracture. Fewer data are available on osteoporosis treatment in men than in women. Objective: The purpose of this study was to evaluate denosumab therapy in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20da2c31e9f294348537f6c1eccbe1f2
https://acuresearchbank.acu.edu.au/item/8833y/a-24-month-study-evaluating-the-efficacy-and-safety-of-denosumab-for-the-treatment-of-men-with-low-bone-mineral-density-results-from-the-adamo-trial
https://acuresearchbank.acu.edu.au/item/8833y/a-24-month-study-evaluating-the-efficacy-and-safety-of-denosumab-for-the-treatment-of-men-with-low-bone-mineral-density-results-from-the-adamo-trial