Zobrazeno 1 - 10 of 157 pro vyhledávání: '"S, Safrin"'
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Penciclovir: a review of its spectrum of activity, selectivity, and cross-resistance pattern
Autor: M. R. Boyd, Kern Er, S. Safrin
Publikováno v: Antiviral Chemistry and Chemotherapy. 4:3-11
The antiherpesvirus agent penciclovir has been evaluated extensively in cell culture. The spectrum of activity of penciclovir against human herpesviruses is similar to that of acyclovir, both compo...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f0d56da54639d51cec39600e89acc63
https://doi.org/10.1177/095632029300401s01
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4
Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir
Autor: K Schubert, Joe Sasadeusz, S. Safrin, Peter K. Cheung, Stephen L. Sacks, Frank Tufaro, M M Hubinette
Publikováno v: Journal of virology. 71(5)
In the majority of cases, the mechanism underlying the resistance to acyclovir (ACV) of herpes simplex viruses (HSVs) is thymidine kinase (TK) deficiency. Plaque isolates from eight ACV-resistant (ACVr) clinical isolates from AIDS patients, of which
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb7af697244608fb434832ad586f73e
https://pubmed.ncbi.nlm.nih.gov/9094663
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5
Pilot study of topical trifluridine for the treatment of acyclovir-resistant mucocutaneous herpes simplex disease in patients with AIDS (ACTG 172). AIDS Clinical Trials Group
Autor: H A, Kessler, S, Hurwitz, C, Farthing, C A, Benson, J, Feinberg, D R, Kuritzkes, T C, Bailey, S, Safrin, R T, Steigbigel, S H, Cheeseman, G F, McKinley, B, Wettlaufer, S, Owens, T, Nevin, J A, Korvick
Publikováno v: Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association. 12(2)
Twenty-six AIDS patients were enrolled in an open label pilot study to evaluate the efficacy and toxicity of topical 1 percent ophthalmic trifluridine solution for the treatment of chronic mucocutaneous herpes simplex virus disease unresponsive to at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1bb854e36ebad582e3859c9b5394bfa5
https://pubmed.ncbi.nlm.nih.gov/8680885
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6
Comparison of three regimens for treatment of mild to moderate Pneumocystis carinii pneumonia in patients with AIDS. A double-blind, randomized, trial of oral trimethoprim-sulfamethoxazole, dapsone-trimethoprim, and clindamycin-primaquine. ACTG 108 Study Group
Autor: S, Safrin, D M, Finkelstein, J, Feinberg, P, Frame, G, Simpson, A, Wu, T, Cheung, R, Soeiro, P, Hojczyk, J R, Black
Publikováno v: Annals of internal medicine. 124(9)
To compare the tolerability and efficacy of three oral regimens for the treatment of patients with the acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii pneumonia.A randomized, double-blind study.24 U.S. academic medical centers.181
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::020a01cd8b13c16b320888dedd4ae534
https://pubmed.ncbi.nlm.nih.gov/9054287
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7
Comparative evaluation of microplate enzyme-linked immunosorbent assay versus plaque reduction assay for antiviral susceptibility testing of herpes simplex virus isolates
Autor: S. Safrin, E. Palacios, Bradley J. Leahy
Publikováno v: Antimicrobial agents and chemotherapy. 40(4)
We tested the antiviral susceptibilities of 30 clinical isolates of herpes simplex virus using the microplate in situ enzyme-linked immunosorbent assay (MISE) and the plaque reduction assay (PRA). There was concordance for 26 of 30 acyclovir results
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72520febcf72bf0bcabb74d56a98d36
https://pubmed.ncbi.nlm.nih.gov/8849218
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9
Cost and outcome of intensive care for patients with AIDS, Pneumocystis carinii pneumonia, and severe respiratory failure
Autor: R M, Wachter, J M, Luce, S, Safrin, D C, Berrios, E, Charlebois, A A, Scitovsky
Publikováno v: JAMA. 273(3)
To determine the costs and outcomes associated with intensive care unit (ICU) admission for patients with acquired immunodeficiency syndrome (AIDS)-related Pneumocystis carinii pneumonia (PCP), and severe respiratory failure.Survival and cost-effecti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8860bb63b0667380a70a47940e527ca2
https://pubmed.ncbi.nlm.nih.gov/7807663
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10
Management of acyclovir-resistant herpes simplex and varicella-zoster virus infections
Autor: H H, Balfour, C, Benson, J, Braun, B, Cassens, A, Erice, A, Friedman-Kien, T, Klein, B, Polsky, S, Safrin
Publikováno v: Journal of acquired immune deficiency syndromes. 7(3)
Persons with AIDS who have CD4+ countsor = 100 and transplant patients, especially bone marrow allograft recipients, may experience clinically significant infections with acyclovir-resistant herpes simplex virus (HSV) or varicella-zoster virus (VZV).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50fc884b13631d39e7d6cd6cd62926aa
https://pubmed.ncbi.nlm.nih.gov/8106965
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