Placebo comparator group selection and use in surgical trials: the ASPIRE project including expert workshop

Autor: Jonathan Pugh, Thomas Pinkney, Barnaby C Reeves, Natalie S Blencowe, Katie Gillies, L. Stefan Lohmander, Andrew Cook, Rachelle Buchbinder, Peter Brocklehurst, Irene Tracey, Sian Cousins, S Rowley, Pascal Probst, Andrew Carr, Amar Rangan, David J Beard, Manuela L. Ferreira, Freddie C. Hamdy, Jane M Blazeby, Brian H Cuthbertson, Jon Nicholl, Naomi Lee, Jonathan Cook, Dair Farrar-Hockley, Ian A. Harris, Charles Weijer, Felicity L. Bishop, Carol Brennan, Marion K Campbell, Richard Huxtable, Julian Savulescu

Publikováno v: Health Technology Assessment, Vol 25, Iss 53 (2021)
Health Technol Assess

The use of placebo comparisons for randomised trials assessing the efficacy of surgical interventions is increasingly being considered. However, a placebo control is a complex type of comparison group in the surgical setting and, although powerful, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16f9bd900277cc2820727ba69776134
https://doi.org/10.3310/hta25530

Analysis of the gap in PCR monitoring availability for patients with chronic myeloid leukemia in 60 low- and middle-income countries

Autor: Jerald P. Radich, Irina Usherenko, Pat Garcia-Gonzalez, Ann Kim Novakowski, Joseph B. Babigumira, Seth S. Rowley

Publikováno v: Cost Effectiveness and Resource Allocation, Vol 19, Iss 1, Pp 1-8 (2021)
Cost Effectiveness and Resource Allocation : C/E

Purpose To estimate the resource gap in the polymerase chain reaction (PCR) monitoring for patients with chronic myeloid leukemia (CML) in low- and middle-income countries (LMICs). Methods We developed a model of demand and supply of PCR monitoring o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1fa313392daaf43855ea017cf90cea
https://doaj.org/article/9a67a2fcc9e14ad592b545c83ce441b8

Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension

Autor: R Sarkar, Alastair K Denniston, Robert M. Golub, J Monteiro, C Haug, D Paltoo, C Mulrow, Hutan Ashrafian, A Jonas, A Y Lee, Xiaoxuan Liu, Livia Faes, M B Panico, Pearse A. Keane, Gary Price, Christopher Yau, L Oakden-Rayner, M K ElZarrad, A L Beam, Gary S. Collins, Hugh Harvey, J Fletcher, David Moher, An-Wen Chan, S Cruz Rivera, Melanie Calvert, Christopher Kelly, L Ferrante di Ruffano, Ara Darzi, Jon Deeks, R Savage, C Espinoza, J Matcham, E Manna, Sebastian J. Vollmer, S Rowley, Christopher Holmes, C S Lee, Andre Esteva, Melissa D McCradden

Publikováno v: e560
e549
The BMJ
The Lancet: Digital Health, Vol 2, Iss 10, Pp e549-e560 (2020)
Nature Medicine
The Lancet. Digital health

The SPIRIT 2013 statement aims to improve the completeness of clinical trial protocol reporting by providing evidence-based recommendations for the minimum set of items to be addressed. This guidance has been instrumental in promoting transparent eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614e0245e3d582a7deea84ee837285a8
https://doi.org/10.1016/s2589-7500(20)30219-3

Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma

Autor: Sharmila Sothi, S. P. Stenning, J. T. Dent, D Alderson, William H. Allum, David Cunningham, Ruth E Langley, Helen Neville-Webbe, Jane M Blazeby, Fay H. Cafferty, Andrew Wotherspoon, Matthew T. Seymour, Tom Crosby, Elizabeth C Smyth, Justin S. Waters, Was Mansoor, S Rowley, Heike I. Grabsch, Suzanne Darby, Joyce Thompson

Publikováno v: Smyth, E C, Rowley, S, Cafferty, F H, Allum, W H, Grabsch, H I, Stenning, S, Wotherspoon, A, Alderson, D, Crosby, T, Mansoor, W, Waters, JS, Neville-Webb, H, Darby, S, Dent, J, Seymour, M, Thompson, J, Sothi, S, Blazeby, J, Langley, RE & Cunningham, D 2019, ' Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma : A Randomized Phase 2 Clinical Trial ', JAMA Oncology . https://doi.org/10.1001/jamaoncol.2019.1179
JAMA Oncology, 5(8), 1181-1187. American Medical Association

Importance Perioperative chemotherapy and surgery are a standard of care for operable gastroesophageal adenocarcinoma. Anti-HER2 therapy improves survival in patients with advanced HER2-positive disease. The safety and feasibility of adding lapatinib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e882ebf594b60a43b213dffd11edc4
https://doi.org/10.1001/jamaoncol.2019.1179

Residence change during the first trimester of pregnancy and adverse birth outcomes

Autor: Seth S. Rowley, Julia C. Bond, Jack Goldberg, Alyson J. Littman, Amanda L Mancenido, Divya M Patil

Publikováno v: Journal of Epidemiology and Community Health. 73:913-919

BackgroundThere are few published studies evaluating the impact of perinatal residence change on infant outcomes and whether these associations differ by socioeconomic status.MethodsWe conducted a population-based cohort study using Washington State

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709fc1bd982ddd7f883fba6a0af7b33a
https://doi.org/10.1136/jech-2018-211937