Zobrazeno 1 - 10 of 138 pro vyhledávání: '"S, Persiani"'
1
P11.24 CR13626, an oral tyrosine kinase inhibitor crossing the blood brain barrier, reduces tumour growth and prolongs survival in a mouse model of glioblastoma
Autor: M Montagna, Tiziana Piepoli, O Letari, R Artusi, Milena Colovic, G Caselli, L C Rovati, Chiara Galimberti, S Persiani
Publikováno v: Neuro Oncol
BACKGROUND Glioblastoma multiforme (GBM) is the most malignant primary brain cancer. Several mutations and alterations of key cellular pathways including tyrosine kinases (TKs) are involved in GBM etiopathogenesis. Currently there is no cure for GBM.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4834f76d275d0d2d6d8d5f4af168cb
https://europepmc.org/articles/PMC6796123/
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2
Hepatitis C virus dynamics and cellular gene expression in uPA ‐ SCID chimeric mice with humanized livers during intravenous silibinin monotherapy
Autor: Alan S. Perelson, Chise Tateno, Sakura Akamatsu, Harel Dahari, Nobuhiko Hiraga, Michio Imamura, Laetitia Canini, S. Persiani, Susan L. Uprichard, Swati DebRoy, Kazuaki Chayama, Clair Nelson Hayes, Ralf T. Pohl
Publikováno v: Journal of Viral Hepatitis. 23:708-717
Legalon SIL (SIL) is a chemically hydrophilized version of silibinin, an extract of milk thistle (Silybum marianum) seeds that has exhibited hepatoprotective and antiviral effectiveness against hepatitis C virus (HCV) in patients leading to viral cle
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33a8f08c579486c0369ab6d1ed1bb33
https://doi.org/10.1111/jvh.12551
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3
Absorption, distribution, metabolism and excretion of the cholecystokinin-1 antagonist dexloxiglumide in the dog
Autor: C, Webber, C A, Stokes, S, Persiani, F, Makovec, A, McBurney, R P, Kapil, B A, John, M, D'Amato, L F, Chasseaud
Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 29:15-23
Single oral doses of 14C-dexloxiglumide were rapidly and extensively absorbed in dogs and also eliminated rapidly with a short half-life. Following single intravenous doses, dexloxiglumide was characterised as a drug having a high clearance (30.7 and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd6ea2ba4788240341bfa8fb0d2de1d
https://doi.org/10.1007/bf03190569
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4
A double-blind, placebo-controlled study to assess tolerability, pharmacokinetics and preliminary pharmacodynamics of single escalating doses of Z13752A, a novel dual inhibitor of the metalloproteases ACE and NEP, in healthy volunteers
Autor: F. Macchi, S. Persiani, M. Bani, G. Moroni, M. Guillaume, A. Colantoni
Publikováno v: British Journal of Clinical Pharmacology. 50:338-349
Aims The objective of this study was to evaluate the tolerability of a novel dual ACE-NEP inhibitor, Z13752A, after the oral administration of rising single doses in healthy volunteers. This study was also a preliminarily investigation of Z13752A pha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37492e1991583c8a466b35837578232c
https://doi.org/10.1046/j.1365-2125.2000.00257.x
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6
Akademický článek
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7
THE EFFECT OF FOOD ON CABERGOLINE PHARMACOKINETICS AND TOLERABILITY IN HEALTHY VOLUNTEERS
Autor: Margherita Strolin-Benedetti, M. Rocchetti, Steve Toon, Beverly I Holt, S. Persiani, M. A. Pacciarini
Publikováno v: Biopharmaceutics & Drug Disposition. 17:443-455
The effect of food on the pharmacokinetics and tolerability of cabergoline in man was investigated. For this purpose an open, randomized, single-dose study was conducted in 12 healthy male volunteers who received 1 mg cabergoline as tablets both unde
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec22346f770bf6aade6a8d5207ae4c27
https://doi.org/10.1002/(sici)1099-081x(199607)17:5<443::aid-bdd443>3.0.co
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10
Akademický článek
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