Zobrazeno 1 - 10
of 3 384
pro vyhledávání: '"S, O'Connor"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1117-1128 (2024)
Cyclodextrins (CDs) are cyclic carbohydrate polymers that hold significant promise for drug delivery and industrial applications. Their effectiveness depends on their ability to encapsulate target molecules with strong affinity and specificity, but q
Externí odkaz:
https://doaj.org/article/67b46e0cd943454484abc846525fd0dd
Autor:
Ryan S. O’Connor, Oliver P. Love, Lyette Régimbald, Audrey Le Pogam, Alexander R. Gerson, Kyle H. Elliott, Anna L. Hargreaves, François Vézina
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Birds maintain some of the highest body temperatures among endothermic animals. Often deemed a selective advantage for heat tolerance, high body temperatures also limits birds’ thermal safety margin before reaching lethal levels. Recent mo
Externí odkaz:
https://doaj.org/article/f59f560d2f2346a4967415c230a07e5f
Autor:
Kimberly Veliz, Feng Shen, Olga Shestova, Maksim Shestov, Alexander Shestov, Sara Sleiman, Tyler Hansen, Roddy S. O’Connor, Saar Gill
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 2, Pp 200819- (2024)
Cell surface molecules transiently upregulated on activated T cells can play a counter-regulatory role by inhibiting T cell function. Deletion or blockade of such immune checkpoint receptors has been investigated to improve the function of engineered
Externí odkaz:
https://doaj.org/article/0b70b3ce58f74dc8b9252276d9958819
Autor:
Audrey Le Pogam, Ryan S. O’Connor, Oliver P. Love, Kevin G. Young, Justine Drolet, Lyette Régimbald, Gabrielle Roy, Francis Robitaille, Dominique Berteaux, Andrew Tam, François Vézina
Publikováno v:
Frontiers in Ecology and Evolution, Vol 12 (2024)
Among birds, several body composition traits typically decrease in size or mass during breeding likely as a result of competing demands during this critical life history stage. However, a recent outdoor captive study in an Arctic-breeding cold-specia
Externí odkaz:
https://doaj.org/article/2ce5ca6ffdd94340995b8b3103c5d15d
Autor:
S.C. Samper Carro, S. O'Connor, S. Kealy, R.K. Jones, C. Raymond, C. Boulanger, S. Hawkins, T. Lu, M.C. Langley, C. Clarkson
Publikováno v:
Quaternary Science Advances, Vol 13, Iss , Pp 100127- (2024)
The cave site known as Matja Kuru 2 (MK2) in Timor-Leste was first occupied ∼40 kya. Of the caves investigated thus far in Timor-Leste MK2 is unique in being located proximal to a large freshwater lake, Ira Lalaro, providing the opportunity to exam
Externí odkaz:
https://doaj.org/article/29708863bd48401ca047e98eba15608f
Autor:
Claire Carvell, Nadine Mitschunas, Rachel McDonald, Sarah Hulmes, Lucy Hulmes, Rory S. O'Connor, Michael P.D. Garratt, Simon G. Potts, Michelle T. Fountain, Dinara Sadykova, Mike Edwards, Marek Nowakowski, Richard F. Pywell, John W. Redhead
Publikováno v:
Basic and Applied Ecology, Vol 58, Iss , Pp 2-14 (2022)
Sown wildflower areas are increasingly recommended as an agri-environmental intervention measure, but evidence for their success is limited to particular insect groups or hampered by the challenges of establishing seed mixes and maintaining flower ab
Externí odkaz:
https://doaj.org/article/caa1f6f55e1049759fe8fcb7074695cf
Autor:
Sarah Senécal, Julie-Camille Riva, Ryan S. O’Connor, Fanny Hallot, Christian Nozais, François Vézina
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract In altricial avian species, nutrition can significantly impact nestling fitness by increasing their survival and recruitment chances after fledging. Therefore, the effort invested by parents towards provisioning nestlings is crucial and repr
Externí odkaz:
https://doaj.org/article/863f06196f794c9bb9f4a2f43f80e852
Autor:
Ryan S. O'Connor, Audrey Le Pogam, Kevin G. Young, Francis Robitaille, Emily S. Choy, Oliver P. Love, Kyle H. Elliott, Anna L. Hargreaves, Dominique Berteaux, Andrew Tam, François Vézina
Publikováno v:
Ecology and Evolution, Vol 11, Iss 4, Pp 1609-1619 (2021)
Abstract Arctic animals inhabit some of the coldest environments on the planet and have evolved physiological mechanisms for minimizing heat loss under extreme cold. However, the Arctic is warming faster than the global average and how well Arctic an
Externí odkaz:
https://doaj.org/article/06f450437a274e409c74e31b47d159d0
Autor:
Alba Rodriguez-Garcia, Rachel C. Lynn, Mathilde Poussin, Monika A. Eiva, Lauren C. Shaw, Roddy S. O’Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, Takami Matsuyama, Daniel J. Powell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endo
Externí odkaz:
https://doaj.org/article/ccc6ff85f88e4afdb0a9c7be290f2a3b
Autor:
Saba Ghassemi, Francisco J. Martinez-Becerra, Alyssa M. Master, Sarah A. Richman, David Heo, John Leferovich, Yitao Tu, Juan Carlos García-Cañaveras, Asma Ayari, Yinan Lu, Ai Wang, Joshua D. Rabinowitz, Michael C. Milone, Carl H. June, Roddy S. O’Connor
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 595-606 (2020)
Effective chimeric antigen receptor (CAR)-T cell therapy is dependent on optimal cell culture methods conducive to the activation and expansion of T cells ex vivo, as well as infection with CAR. Media formulations used in CAR-T cell manufacturing hav
Externí odkaz:
https://doaj.org/article/3c8878a6387c4c229e27c84bfdffb1ba