Zobrazeno 1 - 10
of 60
pro vyhledávání: '"S, Nikulasson"'
Autor:
L Valenick, Katia Karalis, A. Pasha, S Nikulasson, Ignazio Castagliuolo, Michael Wlk, Charalabos Pothoulakis
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 280:G539-G545
We examined the role of glucocorticoids in acute inflammatory diarrhea mediated by Clostridium difficile toxin A. Toxin A (5 μg) or buffer was injected in rat ileal loops, and intestinal responses were measured after 30 min to 4 h. Ileal toxin A adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e406f8cac81b87aedadf5013a18512
https://doi.org/10.1152/ajpgi.2001.280.4.g539
https://doi.org/10.1152/ajpgi.2001.280.4.g539
Autor:
S Nikulasson, Bosheng Qiu, Ignazio Castagliuolo, Ashok Sengupta, Charalabos Pothoulakis, Andrew C. Keates
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 274:G196-G202
We have previously reported that pretreatment of rats with capsaicin (an agent that ablates sensory neurons) or CP-96345 (a substance P receptor antagonist) dramatically inhibits fluid secretion and intestinal inflammation in ileal loops exposed to C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa1e2332f691e9992cc59d057029548
https://doi.org/10.1152/ajpgi.1998.274.1.g196
https://doi.org/10.1152/ajpgi.1998.274.1.g196
Autor:
Ignazio Castagliuolo, Ciaran P. Kelly, Susan E. Leeman, Charalabos Pothoulakis, S Nikulasson, Bosheng Qiu, Andrew C. Keates
Publikováno v:
Proceedings of the National Academy of Sciences. 94:4788-4793
Previously we reported that pretreatment of rats with the substance P (SP) antagonist CP-96,345 inhibits the enterotoxic responses following administration of toxin A fromClostridium difficileinto ileal loops, indicating that SP participates in the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd938503daad40d6bf53c37e440de8a
https://doi.org/10.1073/pnas.94.9.4788
https://doi.org/10.1073/pnas.94.9.4788
Autor:
Susan E. Leeman, Robert E. Carraway, Ignazio Castagliuolo, Charalabos Pothoulakis, Erzsébet Bartolák-Suki, Bosheng Qiu, S Nikulasson
Publikováno v:
Proceedings of the National Academy of Sciences. 93:12611-12615
We previously reported that short-term immobilization stress of rats causes increased colonic mucin release, goblet cell depletion, prostaglandin E2 secretion, and colonic mast cell activation, as well as increased colonic motility. The purpose of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc6e9545d0f281e50c576b20e4f19da
https://doi.org/10.1073/pnas.93.22.12611
https://doi.org/10.1073/pnas.93.22.12611
Autor:
C Pothoulakis, TA Brasitus, Ignazio Castagliuolo, Ciaran P. Kelly, J T LaMont, U Galili, PK Dudeja, S Nikulasson
Publikováno v:
Gastroenterology. 110:1704-1712
BACKGROUND & AIMS: Nearly all human sera contain an immunoglobulin G antibody (antigalactose) that binds the trisaccharide Gal alpha 1-3Gal beta 1-4GlcNAc expressed on cells from most mammals but not humans. Because the Clostridium difficile toxin A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f36984e5336f23a72d5292b3d31ede
https://doi.org/10.1053/gast.1996.v110.pm8964394
https://doi.org/10.1053/gast.1996.v110.pm8964394
Publikováno v:
The American journal of physiology. 276(2)
Reactive oxygen metabolites (ROMs) contribute to the pathophysiology of intestinal inflammation. Our aim was to ascertain the involvement of ROMs in experimental ileitis in rats produced by toxin A of Clostridium difficile. Intraluminal toxin A cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02abebd791e1cebc17a0b5f52ae3f60f
https://pubmed.ncbi.nlm.nih.gov/9950823
https://pubmed.ncbi.nlm.nih.gov/9950823
Autor:
Ignazio Castagliuolo, A. Pasha, S Nikulasson, Barry K. Wershil, Charalabos Pothoulakis, Katia Karalis
Publikováno v:
Scopus-Elsevier
We recently reported that immobilization stress increased colonic motility, mucin, and prostaglandin E2(PGE2) release and mucosal mast cell degranulation in rat colon [ Proc. Natl. Acad. Sci. USA 93: 12611–12615, 1996; Am. J. Physiol. 271 ( Gastroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1c8a293b9125646e6c2aaad8d65399
https://pubmed.ncbi.nlm.nih.gov/9696710
https://pubmed.ncbi.nlm.nih.gov/9696710
Autor:
A. Pasha, S Nikulasson, Charalabos Pothoulakis, Martin Riegler, Bao Lu, Craig Gerard, Ignazio Castagliuolo, Norma P. Gerard
Publikováno v:
Scopus-Elsevier
Toxin A, a 308,000-Mr enterotoxin from Clostridium difficile, mediates antibiotic-associated diarrhea and colitis in humans. Injection of toxin A into animal intestine triggers an acute inflammatory response characterized by activation of sensory neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5583fb62f4a493449102feb7c0458a
https://pubmed.ncbi.nlm.nih.gov/9541482
https://pubmed.ncbi.nlm.nih.gov/9541482
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 10(5)
The aim of this study was to assess the role of MIB-1 in the classification of cervical squamous lesions and to compare it with a novel proliferation marker, topoisomerase II alpha (TP II alpha). We classified 46 archival uterine cervical cases into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a2ecf4e429feb9a82e3b4b2f6c3436d
https://pubmed.ncbi.nlm.nih.gov/9160303
https://pubmed.ncbi.nlm.nih.gov/9160303
Autor:
Ignazio Castagliuolo, C Pothoulakis, H P Desai, YS Hitti, G Semenza, S Nikulasson, Ciaran P. Kelly, Joanne K. Linevsky, T D Wilkins, J. T. Lamont, C Cladaras, R. J. Gilbert, J S Montcrief
Publikováno v:
Scopus-Elsevier
The intestinal effects of Clostridium difficile toxin A are inidated by toxin binding to luminal enterocyte receptors. We reported previously that the rabbit ileal brush border (BB) receptor is a glycoprotein with an alpha-d-galactose containing tris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fa41ccfb3a7b802825f35ef63d2c9f
https://pubmed.ncbi.nlm.nih.gov/8698855
https://pubmed.ncbi.nlm.nih.gov/8698855