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Health Assessment of Polycyclic Aromatic Hydrocarbon Mixtures: Current Practices and Future Directions

Autor: S. H. Rieth, G. L. Foureman, D. L. Murphy, R. Hertzberg, L. Flowers, V. J. Cogliano, E. L. Hofmann, R. S. Schoeny, S. Nesnow

Publikováno v: Polycyclic Aromatic Compounds. 22:811-821

The U.S. EPA's Integrated Risk Information System (IRIS) program has initiated a health assessment for polycyclic aromatic hydrocarbon (PAH) mixtures. The IRIS program develops EPA consensus scientific positions on potential human health effects from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ff410b321efa15a94452da3a1951b27
https://doi.org/10.1080/10406630290103960

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Correlation of carcinogenic potency with mouse-skin 32P-postlabeling and muta-Rmouse lac Z− mutation data for DMBA and its K-region sulphur isostere: comparison with activities observed in standard genotoxicity assays

Autor: N.J. Jones, Helen Tinwell, S. Curti, Herbert S. Rosenkranz, James M. Parry, D. Brusick, D. Paton, R.D. Callander, D. Gilman, John Ashby, B.C. Myhr, S. Nesnow

Publikováno v: Mutation Research/Environmental Mutagenesis and Related Subjects. 292:25-40

The genotoxicities in vitro and in vivo of the mouse-skin carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) have been compared with those of its weakly carcinogenic 4,5-sulphur analogue, 6,11-dimethylbenzo[b]naphtho-[2,3-d]thiophene (S-DMBA). The only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6e632442f0491a9f604d2bb40bddc5
https://doi.org/10.1016/0165-1161(93)90005-k

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A method for combining and comparing short-term genotoxicity test data: Preface

Autor: J. Ashby, D.J. Brusick, Mortimer L. Mendelsohn, Paul H.M. Lohman, F.J. de Serres, S. Nesnow, B.E. Matter, Michael D. Waters, Dan H. Moore, Taijiro Matsushima

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 266:1-6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4054f10eca7e5a7645305d7f83204f29
https://doi.org/10.1016/0027-5107(92)90217-p

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Polycyclic aromatic hydrocarbons: correlations between DNA adducts and ras oncogene mutations

Autor: J A, Ross, S, Nesnow

Publikováno v: Mutation research. 424(1-2)

This review describes a series of studies on the tumorigenic activities of polycyclic aromatic hydrocarbons (PAHs) in various experimental animal model systems, their abilities to form PAH-DNA adducts in target tissues, and their abilities to mutate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e234954721e3a8ceb425ddf1a0bc5ce9
https://pubmed.ncbi.nlm.nih.gov/10064858

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Metabolic activation of racemic and enantiomeric trans-8, 9-dihydroxy-8,9-dihydrodibenzo[a,l]pyrene (dibenzo[def,p]chrysene) to dibenzo[a,l]pyrene-bis-dihydrodiols by induced rat liver microsomes and a recombinant human P450 1A1 system: the role of the K-region-derived metabolic intermediates in the formation of dibenzo[a,l]pyrene-DNA adducts

Autor: S, Nesnow, C, Davis, W, Padgett, M, George, G, Lambert, F, Meyers, J, Allison, L, Adams, L C, King

Publikováno v: Chemical research in toxicology. 11(12)

Metabolic activation studies of dibenzo[a,l]pyrene (DB[a,l]P) (dibenzo[def,p]chrysene), an extremely potent environmental carcinogen, have been focused on metabolism at the fjord region, a region associated with high mutagenic and carcinogenic activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b248347521f3b7016bf20a56369470f
https://pubmed.ncbi.nlm.nih.gov/9860506

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Adenomas induced by polycyclic aromatic hydrocarbons in strain A/J mouse lung correlate with time-integrated DNA adduct levels

Autor: J A, Ross, G B, Nelson, K H, Wilson, J R, Rabinowitz, A, Galati, G D, Stoner, S, Nesnow, M J, Mass

Publikováno v: Cancer research. 55(5)

The induction of DNA adducts and adenomas in the lungs of strain A/J mice has been investigated following the single i.p. administration of each of the following polycyclic aromatic hydrocarbons (PAH): pyrene, dibenz[a,h]anthracene, benzo[a]pyrene, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13e8e7d41a03f4fe9463f25381522fb6
https://pubmed.ncbi.nlm.nih.gov/7866986

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Morphological transformation of C3H10T1/2CL8 cells by cyclopenta-fused derivatives of benzo[a]pyrene and benzo[e]pyrene

Autor: S, Nesnow, S, Beck, L M, Ball, R, Sangaiah, A, Gold

Publikováno v: Cancer letters. 74(1-2)

Cyclopenta-fused homologs of polycyclic aromatic hydrocarbons (PAH) have proven to be more genotoxic and tumorigenic than their parent PAHs. In an effort to uncover their mechanisms of metabolic activation, the morphological transforming activities o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32f049935cb6c0d40f58441e24bc2272
https://pubmed.ncbi.nlm.nih.gov/8287368

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32P-postlabelling in studies of polycyclic aromatic hydrocarbon activation

Autor: J A, Ross, S, Nesnow

Publikováno v: IARC scientific publications. (124)

Polycyclic aromatic hydrocarbons (PAHs) undergo metabolic activation reactions to yield intermediates that react with DNA to form covalent adducts. PAH administration leads to the formation of various types of DNA adducts that may differ between spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5cea3dc226bc8e14c6c93ce16eb6769a
https://pubmed.ncbi.nlm.nih.gov/8225511

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