Zobrazeno 1 - 10
of 151
pro vyhledávání: '"S, Neben"'
Autor:
Michael Kim, Mandeep Takhar, S. Neben, John R. Androsavich, Tania Valencia, Vishal Patel, Philip Bentley, Kara Kersjes, Scott Davis, Edmund C. Lee, Tiffany Chu, Randy Soriano, Jian Li, Sole Gatto, Kai Liu, Salma Sarwary, Andrea Flaten, Adam Pavlicek, Steven Lockton, Matanel Yheskel, Charles R. Allerson, Wright Timothy, Julia Kaplan, Graham Jang, Tate Owen, Annelie Schairer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in either PKD1 or PKD2 genes, is one of the most common human monogenetic disorders and the leading genetic cause of end-stage renal disease. Unfortunately, treatment options f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e809ea9491fb4f3ac4e4d5c8307726f
http://link.springer.com/article/10.1038/s41467-019-11918-y
http://link.springer.com/article/10.1038/s41467-019-11918-y
Autor:
Michael Huang, Adam Pavlicek, Ad C. van Nuenen, S.B. Willemse, Neeltje A. Kootstra, J. Marleen L. de Vree, F. Stelma, Janke Schinkel, Svend Rietdijk, Salah Hadi, P. Grint, Eva van der Veer, Meike H. van der Ree, S. Neben, Kai Liu, Richard Molenkamp, Jacqueline Blem, Marc van der Valk, Amy K Patick, John Grundy, Neil W. Gibson, Marten Harbers, Ulrich Beuers, Hendrik W. Reesink
Publikováno v:
The Lancet, 389(10070), 709-717. ELSEVIER SCIENCE INC
Lancet, 389(10070), 709-717. Elsevier Limited
Lancet, 389(10070), 709-717. Elsevier Limited
Summary Background miR-122 is an important host factor for hepatitis C virus (HCV) replication. The aim of this study was to assess the safety and tolerability, pharmacokinetics, and antiviral effect of a single dose of RG-101, a hepatocyte targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ada5969206c992947817864c14051a
https://doi.org/10.1016/S0140-6736(16)31715-9
https://doi.org/10.1016/S0140-6736(16)31715-9
Hepatitis C virus (HCV) depends on liver-specific microRNA miR-122 for efficient viral RNA amplification in liver cells. This microRNA interacts with two different conserved sites at the very 5’ end of the viral RNA, enhancing miR-122 stability and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e5594bbc79ddb096ca99825913229d
https://doi.org/10.1101/469841
https://doi.org/10.1101/469841
Autor:
Ashley D. Berkebile, Audrey D. McConnell, Peter Bowers, Joseph C. Sheffer, John L. Macomber, David J. King, Steven S. Neben, Andy P. Chen, Robert A. Horlick, Irina P. Krapf, Vladimir Spasojevich
Publikováno v:
Protein Engineering Design and Selection. 26:151-164
Antibodies are important tools for a broad range of applications due to their high specificity and ability to recognize virtually any target molecule. However, in order to be practically useful, antibodies must be highly stable and bind their target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7315cc105800b3843017cde32deb94dc
https://doi.org/10.1093/protein/gzs090
https://doi.org/10.1093/protein/gzs090
Autor:
Laurence Altobell, Trevin Holland, Betty F. Wu, Geoffrey L. Tomlinson, Xue Zhang, Ashley D. Berkebile, Betty Chau, Rachelle M. Toobian, Robert A. Horlick, Steven S. Neben, John L. Macomber, David J. King, Jennifer L. Dalton, Tamlyn Y. Neben, Andy P. Chen, Irina P. Krapf, Heather A. Jones, Audrey D. McConnell, William J. Boyle, Peter Bowers
Publikováno v:
Proceedings of the National Academy of Sciences. 108:20455-20460
A novel approach has been developed for the isolation and maturation of human antibodies that replicates key features of the adaptive immune system by coupling in vitro somatic hypermutation (SHM) with mammalian cell display. SHM is dependent on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e75ec7744f8b52feb415f2e0ec09038
https://doi.org/10.1073/pnas.1114010108
https://doi.org/10.1073/pnas.1114010108
Autor:
M. Paterlini, P. Marshall, Francisco Javier Hernandéz-Molina, Gabriele Uenzelmann-Neben, M. A. Arecco, M. de Isasi, Luis Somoza, Roberto A. Violante, S. Neben, Michele Rebesco
Publikováno v:
Marine and Petroleum Geology. 27:1508-1530
Partially buried giant drifts are located in the southern-most sector of the Argentine continental margin, generating a bathymetric jump at the base of the slope. They are characterised as giant, asymmetrical elongated, mounded contourite drifts, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::071a7b01c01a93518d22d6c15d865680
https://doi.org/10.1016/j.marpetgeo.2010.04.003
https://doi.org/10.1016/j.marpetgeo.2010.04.003
Publikováno v:
Marine Geophysical Researches. 25:233-245
On the basis of new geophysical data acquired by the Federal Institute of Geosciences and Natural Resources (BGR) and the Polar Marine Geological Research Expedition (PMGRE) as well as existing data new geophysical maps were compiled for the Lazarev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::322d99828ce418417604f55e3d4bd7ea
https://doi.org/10.1007/s11001-005-1319-y
https://doi.org/10.1007/s11001-005-1319-y
Autor:
S.B. Willemse, M. van der Valk, J. Marleen L. de Vree, P. Grint, M.J. Sinnige, M.H. van der Ree, Neeltje A. Kootstra, F. Stelma, H. W. Reesink, S. Neben
Publikováno v:
Journal of Hepatology. 64:S415-S416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c2ff92027507e92d4306060d7dce08b
https://doi.org/10.1016/s0168-8278(16)00667-x
https://doi.org/10.1016/s0168-8278(16)00667-x
Autor:
Vesna Marchig, H. Beiersdorf, W. Weiss, N. von Mirbach, S. Neben, Heiko Sahling, A. Afiat, Georg Delisle, Michael Wiedicke, Eckhard Faber
Publikováno v:
Marine Geology. 184:121-141
RV Sonne cruise SO139 discovered active fluid venting at an anticline structure in the fore-arc basin of the Sunda Arc south of Java. Fluid venting is indicated by methane anomalies in the water column, elevated heat flow, vent-typical macrofauna, au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f56a06de2836c096b4a3212c44d53e6
https://doi.org/10.1016/s0025-3227(01)00278-x
https://doi.org/10.1016/s0025-3227(01)00278-x
Publikováno v:
Marine Geology. 172:57-73
Conical mounds, 1–1.5 km in diameter, and up to 65 m high were mapped at the foot of the active Makran continental margin. The mounds developed seaward of the accretionary front in a relatively planar zone where the beginning of build-up of tectoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eee0e596adb93e2e5b66e862d8c117a5
https://doi.org/10.1016/s0025-3227(00)00127-4
https://doi.org/10.1016/s0025-3227(00)00127-4