Zobrazeno 1 - 10
of 357
pro vyhledávání: '"S, Mumm"'
Autor:
Abigail V. Sharrock, Jeff S. Mumm, Elsie M. Williams, Narimantas Čėnas, Jeff B. Smaill, Adam V. Patterson, David F. Ackerley, Gintautas Bagdžiūnas, Vickery L. Arcus
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6593 (2024)
Bacterial nitroreductase enzymes capable of activating imaging probes and prodrugs are valuable tools for gene-directed enzyme prodrug therapies and targeted cell ablation models. We recently engineered a nitroreductase (E. coli NfsB F70A/F108Y) for
Externí odkaz:
https://doaj.org/article/35db6809fd4042d9882cc7c017640035
Autor:
Kevin Emmerich, David T. White, Siva P. Kambhampati, Grace L. Casado, Tian-Ming Fu, Zeeshaan Chunawala, Arpan Sahoo, Saumya Nimmagadda, Nimisha Krishnan, Meera T. Saxena, Steven L. Walker, Eric Betzig, Rangaramanujam M. Kannan, Jeff S. Mumm
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Retinal Müller glia function as injury-induced stem-like cells in zebrafish but not mammals. However, insights gleaned from zebrafish have been applied to stimulate nascent regenerative responses in the mammalian retina. For instance, micro
Externí odkaz:
https://doaj.org/article/0098c0b5f2dd4606b3cf44ca818c8a43
Autor:
Kevin Emmerich, Steven L Walker, Guohua Wang, David T White, Anneliese Ceisel, Fang Wang, Yong Teng, Zeeshaan Chunawala, Gianna Graziano, Saumya Nimmagadda, Meera T Saxena, Jiang Qian, Jeff S Mumm
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010905 (2023)
Retinal Müller glia (MG) can act as stem-like cells to generate new neurons in both zebrafish and mice. In zebrafish, retinal regeneration is innate and robust, resulting in the replacement of lost neurons and restoration of visual function. In mice
Externí odkaz:
https://doaj.org/article/c62e0f14c7364e70aaca457b9089e57d
Autor:
Tori R. Tucker, Courtney A. Knitter, Deena M. Khoury, Sheida Eshghi, Sophia Tran, Abigail V. Sharrock, Travis J. Wiles, David F. Ackerley, Jeff S. Mumm, Michael J. Parsons
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 8 (2023)
Externí odkaz:
https://doaj.org/article/e6303cd05e3f43ad9e16ca58bfd17559
Autor:
Bria L. Macklin, Ying-Yu Lin, Kevin Emmerich, Emily Wisniewski, Brian M. Polster, Konstantinos Konstantopoulos, Jeff S. Mumm, Sharon Gerecht
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Human-induced pluripotent stem cell-derived endothelial cells (iECs) provide opportunities to study vascular development and regeneration, develop cardiovascular therapeutics, and engineer model systems for drug screening. The differentiatio
Externí odkaz:
https://doaj.org/article/58c63a23ffee4ef0bbf623149ed16d22
Autor:
Abigail V. Sharrock, Jeff S. Mumm, Gintautas Bagdžiūnas, Narimantas Čėnas, Vickery L. Arcus, David F. Ackerley
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6633 (2023)
Bacterial nitroreductase enzymes that convert prodrugs to cytotoxins are valuable tools for creating transgenic targeted ablation models to study cellular function and cell-specific regeneration paradigms. We recently engineered a nitroreductase (“
Externí odkaz:
https://doaj.org/article/21201999246246888e8c73450d17b29c
Autor:
Abigail V. Sharrock, Sarah P. McManaway, Michelle H. Rich, Jeff S. Mumm, Ian F. Hermans, Moana Tercel, Frederik B. Pruijn, David F. Ackerley
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Bacterial nitroreductase enzymes that can efficiently convert nitroaromatic prodrugs to a cytotoxic form have numerous applications in targeted cellular ablation. For example, the generation of cytotoxic metabolites that have low bystander potential
Externí odkaz:
https://doaj.org/article/84cc219bd1d44edcb71e6c37eef0a1bb
Autor:
Liyun Zhang, Conan Chen, Jie Fu, Brendan Lilley, Cynthia Berlinicke, Baranda Hansen, Ding Ding, Guohua Wang, Tao Wang, Daniel Shou, Ying Ye, Timothy Mulligan, Kevin Emmerich, Meera T Saxena, Kelsi R Hall, Abigail V Sharrock, Carlene Brandon, Hyejin Park, Tae-In Kam, Valina L Dawson, Ted M Dawson, Joong Sup Shim, Justin Hanes, Hongkai Ji, Jun O Liu, Jiang Qian, David F Ackerley, Baerbel Rohrer, Donald J Zack, Jeff S Mumm
Publikováno v:
eLife, Vol 10 (2021)
Retinitis pigmentosa (RP) and associated inherited retinal diseases (IRDs) are caused by rod photoreceptor degeneration, necessitating therapeutics promoting rod photoreceptor survival. To address this, we tested compounds for neuroprotective effects
Externí odkaz:
https://doaj.org/article/ae361e62a3fd4acc8161a7ed3eae9011
Autor:
Laura Asnaghi, David T. White, Lynn Yoon, Antoinette Price, Grace Y. Lee, Arpan Sahoo, Jeff S. Mumm, Charles G. Eberhart
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Retinoblastoma is the most common intraocular malignancy in children. We previously found that the ACVR1C/SMAD2 pathway is significantly upregulated in invasive retinoblastoma samples from patients. Here we studied the role of an ACVR1C liga
Externí odkaz:
https://doaj.org/article/8cff5bcb009d404d8a5efdcde30e776b
Publikováno v:
Current Osteoporosis Reports. 21:85-94
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4455bed09a88179728636c2d1893790
https://doi.org/10.1007/s11914-022-00762-7
https://doi.org/10.1007/s11914-022-00762-7