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Akademický článek

Investigating the potential for students to contribute to climate data rescue: Introducing the Climate Data Rescue Africa project (CliDaR‐Africa)

Autor: S. Noone, C. D'Arcy, S. Donegan, W. Durkan, B. Essel, K. Healion, H. Hersbach, S. Madden, J. Marshall, L. McConnell, I. Mensah, N. Scroxton, S. Thiesen, P. Thorne

Publikováno v: Geoscience Data Journal, Vol 11, Iss 4, Pp 758-774 (2024)

Abstract The majority of available climate data in global digital archives consist of data only from the 1940s or 1950s onwards, and many of these series have gaps and/or are available for only a subset of the variables which were actually observed.

Externí odkaz: https://doaj.org/article/916e32e1214a4982adf20c1330ea5e37

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Akademický článek

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

Publikováno v: iScience, Vol 25, Iss 8, Pp 104787- (2022)

Summary: Despite much progress in developing better drugs, many patients with acute myeloid leukemia (AML) still die within a year of diagnosis. This is partly because it is difficult to identify therapeutic targets that are effective across multiple

Externí odkaz: https://doaj.org/article/41383f2f5a8d4ffeb2940ad8bb573d15

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Akademický článek

Chronic Stress Exposure Suppresses Mammary Tumor Growth and Reduces Circulating Exosome TGF-β Content via β-Adrenergic Receptor Signaling in MMTV-PyMT Mice

Autor: Ryan P Dawes, Kathleen A Burke, Daniel K Byun, Zhou Xu, Petr Stastka, Leland Chan, Edward B Brown, Kelley S Madden

Publikováno v: Breast Cancer: Basic and Clinical Research, Vol 14 (2020)

Preclinical models of breast cancer have established mechanistic links between psychological stress and cancer progression. However, epidemiological evidence linking stress and cancer is equivocal. We tested the impact of stress exposure in female mi

Externí odkaz: https://doaj.org/article/d4139f1831e34ef887c0debdfec2eac0

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Akademický článek

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Akademický článek

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Data from The Antidepressant Desipramine and α2-Adrenergic Receptor Activation Promote Breast Tumor Progression in Association with Altered Collagen Structure

Autor: Kelley S. Madden, Edward B. Brown, Ryan P. Dawes, Kathleen A. Burke, Mercedes J. Szpunar

Emotional stress activates the sympathetic nervous system (SNS) and release of the neurotransmitter norepinephrine to promote breast tumor pathogenesis. We demonstrate here that the metastatic mammary adenocarcinoma cell line 4T1 does not express fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15edaa5d966ddf1dc7f756b210de1eb8
https://doi.org/10.1158/1940-6207.c.6544250

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Data Supplement from The Antidepressant Desipramine and α2-Adrenergic Receptor Activation Promote Breast Tumor Progression in Association with Altered Collagen Structure

Autor: Kelley S. Madden, Edward B. Brown, Ryan P. Dawes, Kathleen A. Burke, Mercedes J. Szpunar

Supplemental Fig. S1. 4T1 Cells Do Not Express Functional a2-AR. High dose DEX-induced effects on 4T1 (A) proliferation and (B) VEGF production in vitro are not blocked by the a2-AR antagonist yohimbine (YOH). (C) The alpha2-AR agonists clonidine (CL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec59b7b81aad27dfac1c7244719e393
https://doi.org/10.1158/1940-6207.22524437.v1

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Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification Techniques

Autor: Maria Chatzopoulou, Katrina S. Madden, Liam J. Bromhead, Christopher Greaves, Thomas J. Cogswell, Solange Da Silva Pinto, Sébastien R. G. Galan, Irene Georgiou, Matthew S. Kennedy, Alice Kennett, Geraint Apps, Angela J. Russell, Graham M. Wynne

Publikováno v: ACS Medicinal Chemistry Letters. 13:262-270

Palladium-catalyzed reactions are among the most commonly used procedures in organic synthesis. The products have a range of uses, including as intermediates in total synthesis and as screening compounds for drug discovery or agrochemical projects. D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0314b69ec7fbe32e5300d6f3aae3078
https://doi.org/10.1021/acsmedchemlett.1c00638

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