Fecal Microbiome Composition Does Not Predict Diet‐Induced TMAO Production in Healthy Adults

Autor: Marc Ferrell, Peter Bazeley, Zeneng Wang, Bruce S. Levison, Xinmin S. Li, Xun Jia, Ronald M. Krauss, Rob Knight, Aldons J. Lusis, J. C. Garcia‐Garcia, Stanley L. Hazen, W. H. Wilson Tang

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 21 (2021)

Background Trimethylamine‐N‐oxide (TMAO) is a small molecule derived from the metabolism of dietary nutrients by gut microbes and contributes to cardiovascular disease. Plasma TMAO increases following consumption of red meat. This metabolic chang

Externí odkaz: https://doaj.org/article/7941dca5c3b14957ac1a96c359ba4971

The nutritional supplement l-alpha glycerylphosphorylcholine promotes atherosclerosis

Autor: Zeneng Wang, Jennie Hazen, Xun Jia, Elin Org, Yongzhong Zhao, Lucas J. Osborn, Nisreen Nimer, Jennifer Buffa, Miranda K. Culley, Daniel Krajcik, Bert-Jan H. van den Born, Koos Zwinderman, Bruce S. Levison, Max Nieuwdorp, Aldons J. Lusis, Joseph A. DiDonato, Stanley L. Hazen

Publikováno v: International journal of molecular sciences, 22(24):13477. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13477
International Journal of Molecular Sciences, Vol 22, Iss 13477, p 13477 (2021)

L-alpha glycerylphosphorylcholine (GPC), a nutritional supplement, has been demonstrated to improve neurological function. However, a new study suggests that GPC supplementation increases incident stroke risk thus its potential adverse effects warran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c2e2234108ad51eee3b02623956241
https://pure.amc.nl/en/publications/the-nutritional-supplement-lalpha-glycerylphosphorylcholine-promotes-atherosclerosis(7750ffdb-18d6-4ab8-ae01-e8a9e0085d8d).html

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Site-specific 5-hydroxytryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high-density lipoprotein biogenesis

Autor: Anthony J. DiDonato, Stanley L. Hazen, Randall A. Hughes, Jennifer A. Buffa, Ibrahim Choucair, Bruce S. Levison, Valentin Gogonea, Maryam Zamanian-Daryoush, Ying Huang, Xinmin S. Li, Joseph A. DiDonato, Andrew D. Ellington

Publikováno v: J Biol Chem

Apolipoprotein A-I (apoA-I) is the major protein constituent of high-density lipoprotein (HDL) and a target of myeloperoxidase-dependent oxidation in the artery wall. In atherosclerotic lesions, apoA-I exhibits marked oxidative modifications at multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b27e136b27ef830c49c9c9580b1835
https://europepmc.org/articles/PMC7152772/

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

Autor: Xiaodong Gu, Stanley L. Hazen, Matthew W Russell, Jennifer A. Buffa, Jose C. Garcia-Garcia, Aldons J. Lusis, Nilaksh Gupta, Jodie Michelle Reed, Sarah M. Skye, Zeneng Wang, Alex G Hurd, Bruce S. Levison, David B. Cody, William T. Barrington, Joseph A. DiDonato, Lin Li, Adam B. Roberts, J. Mark Brown, Ashraf Duzan, Xiaoming Fu, Jennifer M. Lang, Alex J Myers, Weifei Zhu, Suguna Rachakonda, Valentin Gogonea

Publikováno v: Nature Medicine. 24:1407-1417

Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite that enhances both platelet responsiveness and in vivo thrombosis potential in animal models, and TMAO plasma levels predict incident atherothrombotic event risks in human clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6a342aa36f6aac1ba9b892198df276
https://doi.org/10.1038/s41591-018-0128-1