The Effect of Mentoring on Undergraduate Mentors: A Systematic Review of the Literature

Autor: Andrew S. Leavitt, Kari L. Nelson, Christine E. Cutucache

Publikováno v: Frontiers in Education, Vol 6 (2022)

Multiple meta-analyses and systematic reviews have been conducted to evaluate methodological rigor in research on the effect that mentoring has on the mentee. However, little reliable information exists regarding the effect of mentoring on the mentor

Externí odkaz: https://doaj.org/article/635f701434944877ba5dcf42a0621648

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Neuroactive Type-A γ-Aminobutyric Acid Receptor Allosteric Modulator Steroids from the Hypobranchial Gland of Marine Mollusk, Conus geographus

Autor: Shrinivasan Raghuraman, Joshua P. Torres, Baldomero M. Olivera, Ronald W. Hughen, Manju Karthikeyan, Chang-Shan Niu, Kevin Chase, Zhenjian Lin, Alan R. Light, Marco Bortolato, Jie Zhang, Lee S. Leavitt, Lili Sun, Noemi D. Paguigan, Roberto Cadeddu, Eric W. Schmidt, Christopher A. Reilly

Publikováno v: Journal of Medicinal Chemistry. 64:7033-7043

In a program to identify pain treatments with low addiction potential, we isolated five steroids, conosteroids A-E (1-5), from the hypobranchial gland of the mollusk Conus geographus. Compounds 1-5 were active in a mouse dorsal root ganglion (DRG) as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f437c0478240b76162c4f0bb243a92b
https://doi.org/10.1021/acs.jmedchem.1c00562

Nicotinic acetylcholine receptor partial antagonist polyamides from tunicates and their predatory sea slugs

Autor: Manju Karthikeyan, Jortan O. Tun, Kevin Chase, Lee S. Leavitt, Albebson L. Lim, Shrinivasan Raghuraman, Cheryl Dowell, Ronald W. Hughen, Alan R. Light, Baldomero M. Olivera, J. M. McIntosh, Jie Zhang, Noemi D. Paguigan, Eric W. Schmidt, Christopher A. Reilly, Zhenjian Lin, Cassandra E. Deering-Rice, Randall T. Peterson

In our efforts to discover new drugs to treat pain, we identified molleamines A-E (1-5) as major neuroactive components of the sea slug, Pleurobranchus forskalii and their prey, Didemnum molle tunicates. The chemical structures of molleamines were el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a93867834e3506529c91e592477639ba
https://doi.org/10.1101/2021.05.17.444536

The Tunicate Metabolite 2-(3,5-Diiodo-4-methoxyphenyl)ethan-1-amine Targets Ion Channels of Vertebrate Sensory Neurons

Autor: Tosifa A. Memon, Nicole Schmitt, Jackson Carter, Kevin Chase, Noemi D. Paguigan, Yannan Yan, Shrinivasan Raghuraman, Zhenjian Lin, Eric W. Schmidt, Albebson L. Lim, Christopher A. Reilly, Bo Hjorth Bentzen, Russell W. Teichert, Manju Karthikeyan, Baldomero M. Olivera, Lee S. Leavitt, Sean Christensen

Publikováno v: Paguigan, N D, Yan, Y, Karthikeyan, M, Chase, K, Carter, J, Leavitt, L S, Lim, A L, Lin, Z, Memon, T, Christensen, S, Bentzen, B H, Schmitt, N, Reilly, C A, Teichert, R W, Raghuraman, S, Olivera, B M & Schmidt, E W 2021, ' The Tunicate Metabolite 2-(3,5-Diiodo-4-methoxyphenyl)ethan-1-amine Targets Ion Channels of Vertebrate Sensory Neurons ', ACS chemical biology, vol. 16, no. 9, pp. 1654-1662 . https://doi.org/10.1021/acschembio.1c00328

Marine tunicates produce defensive amino-acid derived metabolites, including 2-(3,5-diiodo-4-methoxyphenyl)ethan-1-amine (DIMTA), but their mechanisms of action are rarely known. Using an assay-guided approach, we found that out of the many different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9884ca44604783f84921e5567db85434
https://curis.ku.dk/ws/files/285240582/The_tunicate_metabolite_2_3_5_diiodo_4_methoxyphenyl_ethan_1_.pdf