Zobrazeno 1 - 10
of 127
pro vyhledávání: '"S, Lönn"'
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 1(10)
Amplification of c-erb-B2 is examined in patients with transitional cell bladder carcinoma. In a pilot study we found that the amplification correlated with high tumor grade. Tumor grade is a known prognostic factor. Therefore, we next examined the p
Publikováno v:
Cancer. 75(11)
Amplification of erb-B2 and myc shows prognostic value in patients with operable breast cancer. Amplification is usually detected in tumor samples remaining after pathologic work-up, preventing the examination of small tumors.Tumor imprints that cont
Publikováno v:
Anticancer research. 14(3A)
We have examined the formation of DNA in rat glioma cells. Cytotoxicity was induced in the cells using BCNU (1,3-bis(2-chloroethyl)-1-nitroso-urea) in the presence or absence of CPZ (chlorpromazine). There was impaired formation of DNA in cells treat
Publikováno v:
Cancer research. 50(11)
Bloom's syndrome (BS) cells display a characteristic genomic instability, notably an elevated frequency of sister-chromatid exchange. Replicating DNA in cultured BS cells was labeled with [3H]thymidine using several time schedules. Separation of DNA
Publikováno v:
Cancer research. 49(5)
5-Fluorouracil and 5-fluorodeoxyuridine induce DNA lesions via two different mechanisms, one involving and the other not involving the incorporation of drug into DNA. The DNA lesions are detected by lysing cells in dilute alkali and then separating t
Publikováno v:
Nucleic acids research. 14(9)
We describe an approach, using alkaline cell lysis and digestion with nuclease S1, which permits to distinguish between newly ligated DNA and the DNA of mature chromatin. When cells with steady-state labelled DNA (mature DNA) are analyzed, the result
Publikováno v:
Cancer research. 48(15)
Leucovorin augments the growth inhibitory effect of 5-fluoropyrimidines on neoplastic cells. The effect is paralleled by much higher levels of DNA fragmentation than in cells treated with 5-fluoropyrimidines alone at the same concentration. The lesio
Publikováno v:
Cancer research. 46(8)
We have examined the induction of alkali-labile regions in DNA of human neoplastic cells treated with 5-fluorouracil and 5-fluorodeoxyuridine. 5-Fluorouracil induces DNA lesions by two mechanisms: incorporation of drug into DNA and a second mechanism
Publikováno v:
Journal of cellular physiology. 138(1)
In human melanoma cells one can detect two discrete DNA replication intermediates, 10-kb DNA intermediates and Okakzaki fragments. Both intermediates are seen when cells are rapidly growing in medium supplemented with fetal calf serum. When the mediu
Publikováno v:
Cancer research. 44(8)
The effect of 5-fluorouracil on the stability of DNA and the synthesis of DNA replication intermediates was analyzed in human colon adenocarcinoma cells. Density gradient analysis showed that some of the drug is incorporated into DNA. Moreover, DNA f