Zobrazeno 1 - 10
of 195
pro vyhledávání: '"S, Kotnis"'
Autor:
Trevor Laird, Jaan A. Pesti, Ahmed F. Abdel-Magid, Daniel Levin, Tony Y. Zhang, Sean P. Lapekas, Thomas Archibald, Stephen M. Stefanick, Ryo Sugiyama, Toru Yamano, Joerg Deerberg, Stefan Abele, Gunther Schmidt, Jacques-Alexis Funel, Mischa Schwaninger, Sven Wagner, Noel A. Hamill, Mark E. Howells, James H. Simpson, Atul S. Kotnis, Rajendra P. Deshpande, David J. Kacsur, Jason Hamm, Gus Kodersha, William Merkl, Daniel Domina, Steve Y. Wang, Nicholas A. Straessler, Louis F. Cannizzo, Michael W. Lesley, Oliver R. Thiel, John R. Huckins, Derek B. Brown, Eric A. Bercot, John T. Colyer, Bobby Riahi, Rob R. Milburn, Steve M. Shaw, Joe Tomaskevitch, David J. Ager, Ayman Allian, Bryan Li, Steven Guinness, L. Mleczko, Dongbo Zhao, Sripathy Venkatraman, Scott Tweedie, Mark McLaws, David Lathbury
Autor:
Jianqing Li, Linda Chu, Venkata B. Nanduri, Atul S. Kotnis, William L. Parker, Richard H. Mueller, Ramesh N. Patel, Mark Liu
Publikováno v:
Tetrahedron: Asymmetry. 16:2778-2783
The enantioselective microbial reduction of 6-oxo-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione 1 to either of the corresponding (R)- or (S)-6-hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c0ead0068215d5d10b0b70885eb1a3e
https://doi.org/10.1016/j.tetasy.2005.07.015
https://doi.org/10.1016/j.tetasy.2005.07.015
Autor:
Ronald L. Hanson, Ramesh N. Patel, William L. Parker, David B. Brzozowski, Atul S. Kotnis, Mark Liu, Thomas P. Tully
Publikováno v:
Tetrahedron: Asymmetry. 16:2711-2716
6-Hydroxybuspirone is an active metabolite of the antianxiety drug buspirone. The (R)- and (S)-enantiomers of 6-hydroxybuspirone were prepared using an enzymatic resolution process. l -Amino acid acylase from Aspergillus melleus (Amano Acylase 30000)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9edda988653835448c5c905474ccf55e
https://doi.org/10.1016/j.tetasy.2005.07.020
https://doi.org/10.1016/j.tetasy.2005.07.020
Autor:
Eric D. Dowdy, Daniel J. Watson, and Simon Leung, B. C. O'reilly, Depue Jeffrey S, Atul S. Kotnis
Publikováno v:
Organic Process Research & Development. 8:616-623
The development of a safe and scalable oxidation process for the hydroxylation of the azapirone psychotropic agent buspirone (1) to furnish 6-hydroxybuspirone (2) is described. A mechanistic understanding of how key process factors affected product q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e165cbef2fe13ab9a6cec45655514bc
https://doi.org/10.1021/op049918r
https://doi.org/10.1021/op049918r
Autor:
Michael Totelben, Richard H. Mueller, Jollie D. Godfrey, James H. Simpson, Jason Hamm, Edward J. Delaney, Victor W. Rosso, Rajendra P. Deshpande, Atul S. Kotnis, Rita Fox, David J. Kacsur
Publikováno v:
Tetrahedron: Asymmetry. 14:3569-3574
Asymmetric cyclopropanation of styrene 1 (as the limiting reagent) was demonstrated using excess ethyl diazoacetate and catalytic Ru(ip-Pybox). Selective hydrolysis of the resulting 90:10 trans : cis mixture of cyclopropane 4 generated cyclopropyl ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6daf43781bfc4eec1ae829be10209c2
https://doi.org/10.1016/j.tetasy.2003.08.041
https://doi.org/10.1016/j.tetasy.2003.08.041
Autor:
Braga FC; Department of Chemistry, Federal University of São Carlos, São Carlos, 13565-905, Brazil., da Silva FLN; Biocatalysis and Organic Synthesis Group - Institute of Chemistry, Federal University of Rio de Janeiro, Cidade Universitária, Rio de Janeiro, 21941-909, Brazil., de O Ramos T; Department of Chemistry, Federal University of São Carlos, São Carlos, 13565-905, Brazil., Rosa JGH; Biocatalysis and Organic Synthesis Group - Institute of Chemistry, Federal University of Rio de Janeiro, Cidade Universitária, Rio de Janeiro, 21941-909, Brazil., de A Araujo É; Biocatalysis and Organic Synthesis Group - Institute of Chemistry, Federal University of Rio de Janeiro, Cidade Universitária, Rio de Janeiro, 21941-909, Brazil., Junior NFC; API Manufacturing Process Development Laboratory, Prati, Donaduzzi & Cia. LTDA, Toledo, Paraná, Brazil., Wendler EP; API Manufacturing Process Development Laboratory, Prati, Donaduzzi & Cia. LTDA, Toledo, Paraná, Brazil., Beatriz A; Research and Innovation Center for Bioprospecting and Synthesis of Products for Human and Animal Health (CIBSINT) - Institute of Chemistry, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., de Souza ROMA; Biocatalysis and Organic Synthesis Group - Institute of Chemistry, Federal University of Rio de Janeiro, Cidade Universitária, Rio de Janeiro, 21941-909, Brazil., Brocksom TJ; Department of Chemistry, Federal University of São Carlos, São Carlos, 13565-905, Brazil., de Oliveira KT; Department of Chemistry, Federal University of São Carlos, São Carlos, 13565-905, Brazil.
Publikováno v:
Chemistry, an Asian journal [Chem Asian J] 2024 Oct 16; Vol. 19 (20), pp. e202400689. Date of Electronic Publication: 2024 Sep 11.
Autor:
David J. Kacsur, Jason Hamm, Daniel Domina, Gus A. Kodersha, Atul S. Kotnis, Steve S. Y. Wang, James H. Simpson, Rajendra P. Deshpande, William Merkl
Publikováno v:
ACS Symposium Series ISBN: 9780841230330
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30def49b74d6a5496511bd01790544a5
https://doi.org/10.1021/bk-2014-1181.ch009
https://doi.org/10.1021/bk-2014-1181.ch009
Autor:
Jack Z. Gougoutas, John C. Harris, and Donald L. Wedding, David A. Thurston, Gus A. Kodersha, David A. Lust, William Early, Dennis Ronald D, Daniel H. Kim, Atul S. Kotnis, Dominique Thoraval, William J. Winter, James L. Berg, Merrill L. Davies, Peter J. Bernot, James H. Simpson, Jerome L. Moniot, Neal G. Anderson, Paul A. Jass, Douglas W. Phillipson, Kai Tse, Droghini Roberto, Andrew Nguyen, Thomas D. Ary, Lajeunesse Jean, John D. Dimarco, Venkatapuram A. Palaniswamy, Hoang D. Do, Gary D. Madding, Oscar W. Haas, Yeung Y. Chan, Polomski Robert E, Rajan P. Deshpande, Chien-Kuang Chen, John A. Grosso, Sandeep P. Modi
Publikováno v:
Organic Process Research & Development. 1:300-310
5-Fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl]propyl]-1H-indole dihydrochloride (1) facilitates 5-HT neurotransmission and was an antidepressant drug candidate. The development of a safe, rugged process for the large-scale, chromatography-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e6663a3ce15b3152d0cb3b0548517d9
https://doi.org/10.1021/op970213h
https://doi.org/10.1021/op970213h
Autor:
Atul S. Kotnis, Mary B. Gardineer, Maria L. Coradetti, Neal G. Anderson, John A. Cronin, Venkatapuram A. Palaniswamy, and David A. Lust, Merrill L. Davies
Publikováno v:
Organic Process Research & Development. 1:315-319
A regioisomeric impurity is routinely formed during preparation of the first intermediate of the fosinopril sodium side chain. This first step, the radical-initiated condensation of 4-phenyl-1-butene (1) and aqueous hypophosphorous acid, provides low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::706781a3d5c2f6e33b50569ca55929fb
https://doi.org/10.1021/op9702105
https://doi.org/10.1021/op9702105
Autor:
Mark Liu, Chenkou Wei, Dale Vanyo, Rachel Mathew, William J. Winter, F. Taha Comezoglu, Kumar Gadamsetti, Victor W. Rosso, Ciro J. Spagnuolo, Gerald L. Powers, Atul S. Kotnis, Raymond E. Weaver, Ambarish K. Singh, Bich D. Phan, David A. Lust, Merrill L. Davies, Kenneth S. Bembenek, Wen-Sen Li, Venkatapuram A. Palaniswamy
Publikováno v:
Organic Process Research & Development. 7:25-27
The final step of the semisynthetic route to paclitaxel involves cleavage of the triethylsilyl (TES) protecting group from the C-7 hydroxyl group. Paclitaxel is an extremely complex molecule, and standard deprotection conditions led to formation of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56da05cea73431e136028ba13fc5eb42
https://doi.org/10.1021/op020221k
https://doi.org/10.1021/op020221k