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Akademický článek
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Autor:
S Hosztafi, Susanna Fürst
Publikováno v:
Acta Physiologica Hungarica. 95:3-44
The object of this review is to summarize the efforts which resulted in the discovery of therapeutically useful morphine-like drugs. The search for new analgesics can be divided into three stages: (a) search for analgesics with high efficacy and redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b973df6a08a71bf32cf64da3b06ac4e1
https://doi.org/10.1556/aphysiol.95.2008.1.1
https://doi.org/10.1556/aphysiol.95.2008.1.1
Publikováno v:
Acta Biologica Hungarica. 54:177-181
The agonistic and antagonistic properties of N-cyclopropylmethyl (N-CPM) morphine derivatives were observed in mouse vas deferens (MVD), longitudinal muscle of guinea pig ileum (GPI) and rabbit vas deferens (LVD). In MVD the K(e) values of the titled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa087f82fc49e5d74c4f960d0e4ab64e
https://doi.org/10.1556/abiol.54.2003.2.6
https://doi.org/10.1556/abiol.54.2003.2.6
Autor:
S, Hosztafi, Z, Fürst
Publikováno v:
Pharmacological Research. 32:15-20
This review surveys the discovery of endogenous alkaloids in mammals. The formation of morphine in mammalian brain was assumed in 1970. The existence of morphine was demonstrated by radioimmunoassay. Identification of morphine was performed by spectr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5598bf94930514b605d5d73c79bd09ca
https://doi.org/10.1016/s1043-6618(95)80003-4
https://doi.org/10.1016/s1043-6618(95)80003-4
Publikováno v:
Current Medicinal Chemistry. 1:423-440
This paper surveys the relationships between the chemical structures and pharmacological activities of natural or semisynthetic 4,5a epoxymorphinans, synthetic morphinans and benzomorphans. Substitution . of the N-methyl group affords strong analge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b4165707da734b374dff28bf144a299
https://doi.org/10.2174/092986730106220216112120
https://doi.org/10.2174/092986730106220216112120
Publikováno v:
Analgesia. 1:785-788
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be27c8a2200830a6c1ad0498cbeade0f
https://doi.org/10.3727/107156995819563889
https://doi.org/10.3727/107156995819563889
Publikováno v:
Analgesia. 1:557-560
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38fd6a97a0362352126d3db31dd45eab
https://doi.org/10.3727/107156995819564031
https://doi.org/10.3727/107156995819564031
Publikováno v:
Monatshefte f�r Chemie Chemical Monthly. 124:291-297
Nitro- and Aminophthalideisoquinolines were synthesized with a new efficient method. The molecular conformation of these derivatives was studied by1H NMR methods. On the basis of these studies tritoqualine was to be found theerythro racemate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3703ff5e68d96bbe4ab20ac0f8f8864c
https://doi.org/10.1007/bf00810586
https://doi.org/10.1007/bf00810586
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d3045179a6a6a098e59d75d0eb81d8
https://doi.org/10.1002/chin.199248224
https://doi.org/10.1002/chin.199248224