Zobrazeno 1 - 10
of 401
pro vyhledávání: '"S, Heeger"'
Autor:
Seokjo Kang, Emily Y. Ko, Amelia E. Andrews, Juliana E. Shin, Karina J. Nance, Pijus K. Barman, Peter S. Heeger, Willard M. Freeman, Bérénice A. Benayoun, Helen S. Goodridge
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Microglia, the brain’s resident macrophages, maintain brain homeostasis and respond to injury and infection. During aging they undergo functional changes, but the underlying mechanisms and their contributions to neuroprotection versus neur
Externí odkaz:
https://doaj.org/article/ea800acc967149ce81f4777b84b82d93
Autor:
Jun Sun, M. Nedim Ince, Clara Abraham, Terrence Barrett, Lisa A. Brenner, Yingzi Cong, Reza Dashti, Pradeep K. Dudeja, David Elliott, Thomas S. Griffith, Peter S. Heeger, Andrew Hoisington, Kaikobad Irani, Tae Kon Kim, Neeraj Kapur, Joseph Leventhal, Mansour Mohamadzadeh, Ece Mutlu, Rodney Newberry, Jonathan U. Peled, Israel Rubinstein, Salyka Sengsayadeth, Chen Sabrina Tan, Xiao-Di Tan, Eric Tkaczyk, Jason Wertheim, Zheng Jenny Zhang
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTThe present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled “Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans.” Our Veteran patient population expe
Externí odkaz:
https://doaj.org/article/35f57b6f47564d71a10ebcf40edbc4b6
Autor:
Zeguo Sun, Zhongyang Zhang, Khadija Banu, Ian W. Gibson, Robert B. Colvin, Zhengzi Yi, Weijia Zhang, Bony De Kumar, Anand Reghuvaran, John Pell, Thomas D. Manes, Arjang Djamali, Lorenzo Gallon, Philip J. O’Connell, John Cijiang He, Jordan S. Pober, Peter S. Heeger, Madhav C. Menon
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Donor-recipient (D-R) mismatches outside of human leukocyte antigens (HLAs) contribute to kidney allograft loss, but the mechanisms remain unclear, specifically for intronic mismatches. We quantified non-HLA mismatches at variant-, gene-, and genome-
Externí odkaz:
https://doaj.org/article/1062a57a1df84d2eb0cec1a6f8b62c10
Autor:
Sofia Bin, Chiara Cantarelli, Julian K. Horwitz, Micaela Gentile, Manuel Alfredo Podestà, Gaetano La Manna, Peter S. Heeger, Paolo Cravedi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundAdministration of recombinant erythropoietin (EPO), a kidney-produced hormone with erythropoietic functions, has been shown to have multiple immunoregulatory effects in mice and humans, but whether physiological levels of EPO regulate immun
Externí odkaz:
https://doaj.org/article/c8f23f4f142d45d783bbc302d4349977
Autor:
Julian K. Horwitz, Sofia Bin, Robert L. Fairchild, Karen S. Keslar, Zhengzi Yi, Weijia Zhang, Vasile I. Pavlov, Yansui Li, Joren C. Madsen, Paolo Cravedi, Peter S. Heeger
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Erythropoietin (EPO) has multiple nonerythropoietic functions, including immune modulation, but EPO’s effects in transplantation remain incompletely understood. We tested the mechanisms linking EPO administration to prolongation of murine heterotop
Externí odkaz:
https://doaj.org/article/1b0271f84e3245dda23663c661913691
Autor:
Farida El Gaamouch, Mickael Audrain, Wei-Jye Lin, Noam Beckmann, Cheng Jiang, Siddharth Hariharan, Peter S. Heeger, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich, Stephen R. Salton
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Background Multiomic studies by several groups in the NIH Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) identified VGF as a major driver of Alzheimer’s disease (AD), also finding that reduced VGF levels correlate wi
Externí odkaz:
https://doaj.org/article/20d91e074df844c7b5db2558788c3e2f
Autor:
Nicholas Chun, Rosalind L. Ang, Mark Chan, Robert L. Fairchild, William M. Baldwin III, Julian K. Horwitz, Jesse D. Gelles, Jerry Edward Chipuk, Michelle A. Kelliher, Vasile I. Pavlov, Yansui Li, Dirk Homann, Peter S. Heeger, Adrian T. Ting
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
TNF ligation of TNF receptor 1 (TNFR1) promotes either inflammation and cell survival by (a) inhibiting RIPK1’s death-signaling function and activating NF-κB or (b) causing RIPK1 to associate with the death-inducing signaling complex to initiate a
Externí odkaz:
https://doaj.org/article/1cef15809b5044ec872dc4819293a566
Autor:
Arun Cumpelik, Peter S. Heeger
Publikováno v:
Current opinion in organ transplantation. 27(5)
In antibody-mediated allograft rejection, donor-reactive antibodies cause transplant injury in part via complement activation. New mechanistic insights indicate complement also modulates development of humoral immune responses. Herein we review recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dedbc35f37c35eac032fcffab5fd21c
https://pubmed.ncbi.nlm.nih.gov/35857345
https://pubmed.ncbi.nlm.nih.gov/35857345
Autor:
Arun Cumpelik, Evan Cody, Samuel Mon-Wei Yu, Emilie K. Grasset, David Dominguez-Sola, Andrea Cerutti, Peter S. Heeger
Publikováno v:
The Journal of Immunology. 210:19-23
T cell–independent (TI) B cell responses to nonprotein Ags involve multiple cues from the innate immune system. Neutrophils express complement receptors and activated neutrophils can release BAFF, but mechanisms effectively linking neutrophil activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce17524efd06377f4662ca50b6058992
https://doi.org/10.4049/jimmunol.2200410
https://doi.org/10.4049/jimmunol.2200410
Autor:
Zeguo Sun, Zhongyang Zhang, Khadija Banu, Yorg Al Azzi, Anand Reghuvaran, Samuel Fredericks, Marina Planoutene, Susan Hartzell, Yesl Kim, John Pell, Gregory Tietjen, William Asch, Sanjay Kulkarni, Richard Formica, Meenakshi Rana, Jonathan S. Maltzman, Weijia Zhang, Enver Akalin, Peter S. Heeger, Paolo Cravedi, Madhav C. Menon
Publikováno v:
medRxiv
BACKGROUND: Kidney transplant recipients (KTRs) with COVID-19 have poor outcomes compared to non-KTRs. To provide insight into management of immunosuppression during acute illness, we studied immune signatures from the peripheral blood during and aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be46dcb02e545af4bc874d8881e1f99b
https://doi.org/10.1681/asn.2022010125
https://doi.org/10.1681/asn.2022010125