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Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina

Autor: Pjotr Knyazev, T. Paech, Andreas Faissner, Georg Zoidl, C. Distler, S. Illes, Axel Ullrich, S. Harroch, Jacqueline Reinhard, Andrea Horvat-Bröcker

Publikováno v: Neuroscience. 152:618-645

Receptor protein tyrosine phosphatases (RPTPs) appear to coordinate many aspects of neural development, including cell proliferation, migration and differentiation. Here we investigated potential roles of RPTPs in the developing mouse retina. Using a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db8ea39f612be39b80f3965b214b998
https://doi.org/10.1016/j.neuroscience.2008.01.016

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Protein tyrosine phosphatases in health and disease

Autor: W. HENDRIKS, A. ELSON, S. HARROCH, R. PULIDO, A. STOKER, J. DEN HERTOG

Publikováno v: FEBS Journal
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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Protein tyrosine phosphatases (PTPs) represent a super-family of enzymes that play essential roles in normal development and physiology. In this review, we will discuss the PTPs that have a causative role in hereditary diseases in humans. In addition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3e470356593e8bde8259929c1d005555
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2072

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Distribution of different isoforms of receptor protein tyrosine phosphatase γ (Ptprg-RPTP γ) in adult mouse brain: upregulation during neuroinflammation

Autor: Elisabetta Moratti, Claudio Sorio, Mario Rosario Buffelli, Erika Lorenzetto, S. Harroch, Marzia Vezzalini

Publikováno v: Brain structurefunction. 219(3)

The receptor protein tyrosine phosphatase γ (Ptprg-RPTPγ) is a receptor protein widely expressed in many tissues, including the central nervous system (CNS). Several RPTPγ isoforms are expressed in the brain during development and in adulthood, bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8a1e85dec922ce824a757ea33fecd8
https://pubmed.ncbi.nlm.nih.gov/23536318

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Interleukin-6 signaling via four transcription factors binding palindromic enhancers of different genes

Autor: Michel Revel, Judith Chebath, S Harroch

Publikováno v: Scopus-Elsevier

Interferons (IFNs), as well as some interleukins, growth factors, and hormones, all induce tyrosine phosphorylation of STAT1 and additional transcription factors of similar sizes. These factors are activated to translocate to nucleus and bind to enha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9fea31c540837e44e543053b196bb7
https://doi.org/10.1016/s0021-9258(18)47177-3

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Unmasking by soluble IL-6 receptor of IL-6 effect on metastatic melanoma: growth inhibition and differentiation of B16-F10.9 tumor cells

Autor: Judith Chebath, Jae Wook Oh, Lea Eisenbach, Michel Revel, Anne Katz, S Harroch

Publikováno v: Scopus-Elsevier

Interleukin-6 (IL-6) inhibits the growth of melanocytes and of early stage melanoma cells, but not that of advanced melanoma cells. The in vitro IL-6 response can be restored in the highly metastatic melanoma B16-F10.9 by addition of recombinant solu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3d20b021b63f0161364bebb98fc5d6
https://pubmed.ncbi.nlm.nih.gov/9247310

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Antagonism of interferon beta on interferon gamma: inhibition of signal transduction in vitro and reduction of serum levels in multiple sclerosis patients

Autor: M, Revel, J, Chebath, M, Mangelus, S, Harroch, G A, Moviglia

Publikováno v: Multiple sclerosis (Houndmills, Basingstoke, England). 1

Interferon gamma (IFN-gamma acts as a mediator of multiple sclerosis (MS) exacerbations through a number of biological effects, such as induction of major histocompatibility class II complexes (MHC-II), macrophage activation and potentiation of tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33b80f1035566eef392e9c221cfb0423
https://pubmed.ncbi.nlm.nih.gov/9345390

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Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta

Autor: S Harroch, L M Shulman, P Eid, Michel Revel, Carolina Abramovich, M Tovey, Edward Ratovitski

The human interferon alpha-receptor (IFNAR gene product) is a transmembranal protein of 557 amino acids with an intracytoplasmic domain of 100 amino acids containing four tyrosines. Antibodies to a C-terminal peptide (residues 521-536) were developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b2c88f4b217c4b8a0d8fbd23ed01ff
https://europepmc.org/articles/PMC395562/

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Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA

Autor: Judith Chebath, S Harroch, Michel Revel

Publikováno v: Scopus-Elsevier

The effects of interleukin-6 (IL-6) on interferon regulatory factor 1 (IRF-1) gene expression were studied in B-hybridoma B9 cells which are growth-stimulated by IL-6 and breast carcinoma T47D cells which are growth-inhibited. IL-6 induced the produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31f5f34401494c247097a21236b3d58
https://pubmed.ncbi.nlm.nih.gov/8168491

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