Zobrazeno 1 - 10
of 82
pro vyhledávání: '"S, Goehle"'
Autor:
Ramya Kollipara, Birgit Heltweg, Yansong Gu, S Goehle, Julian A. Simon, Ronald A. DePinho, Antonio Bedalov, Aaron D. Schuler, Hongzhe Li, Jeff Posakony, Tonibelle Gatbonton
Publikováno v:
Cancer Research. 66:4368-4377
SIRT1 and other NAD-dependent deacetylases have been implicated in control of cellular responses to stress and in tumorigenesis through deacetylation of important regulatory proteins, including p53 and the BCL6 oncoprotein. Hereby, we describe the id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c1bc8dedbc1c36d87c4133896c6ec6
https://doi.org/10.1158/0008-5472.can-05-3617
https://doi.org/10.1158/0008-5472.can-05-3617
Autor:
S Goehle, Julian A. Simon, John R. Lamb, Philippe Szankasi, Catherine Ludlow, David R. H. Evans, Heather M. Dunstan, Michelle Cronk
Publikováno v:
JNCI Journal of the National Cancer Institute. 94:88-94
Background: We are developing cell-based assays to identify anticancer agents that are selectively toxic to cells with defined mutations. As a test, we used a three-stage strategy to screen compounds from the National Cancer Institute’s repository
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354c1ac98c043500c71ac82a62da9a96
https://doi.org/10.1093/jnci/94.2.88
https://doi.org/10.1093/jnci/94.2.88
Publikováno v:
BioTechniques. 30:1118-1124
The primary goal of anticancer chemotherapy is to kill cancer cells. Therefore, it is of critical importance that any assay that is used to determine the toxicity of a potential anticancer drug accurately measures viability. While colony formation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87725e1f8f927b4e512ce91f242a3d59
https://doi.org/10.2144/01305dd04
https://doi.org/10.2144/01305dd04
Autor:
B Darovsky, S Goehle, C. Von Kalle, Theodore C. Graham, Friedrich Schuening, Rainer Storb, Jordi Barquinero, Kristy Seidel, Hans-Peter Kiem
Publikováno v:
Blood. 85:1195-1201
We have studied the role of different conditioning regimens for engraftment of genetically marked hematopoietic repopulating cells in dogs. Peripheral blood (PB) and/or marrow cells collected after treatment with recombinant canine stem cell factor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8517abb4bcc05f8a9bf6bdc2d95611be
https://doi.org/10.1182/blood.v85.5.1195.bloodjournal8551195
https://doi.org/10.1182/blood.v85.5.1195.bloodjournal8551195
Autor:
Beverly Torok-Storb, Rainer Storb, Shelly Heimfeld, Hans-Peter Kiem, S Goehle, C. Von Kalle, B Darovsky, Friedrich Schuening
Publikováno v:
Blood. 84:2890-2897
Retroviral-mediated gene transfer is the most attractive modality for gene transfer into hematopoietic stem cells. However, transduction efficiency has been low using amphotropic Moloney murine leukemia virus (MoMLV) vectors. In this study, we invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4296292658c0b34021af0ee2625260
https://doi.org/10.1182/blood.v84.9.2890.bloodjournal8492890
https://doi.org/10.1182/blood.v84.9.2890.bloodjournal8492890
Autor:
K Kawahara, R To, LD Fisher, K Mullally, A D Miller, FR Appelbaum, D Stewart, Theodore C. Graham, S Goehle, Friedrich Schuening
Publikováno v:
Blood. 78:2568-2576
Amphotropic helper-free retrovirus vectors containing the bacterial neomycin phosphotransferase gene (neo) and the human adenosine deaminase gene (adenosine aminohydrolase, EC 3.5.4.4; ADA) were used to transduce canine marrow cells. In one approach,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2d45389f9ecd6398943992578f2f90
https://doi.org/10.1182/blood.v78.10.2568.bloodjournal78102568
https://doi.org/10.1182/blood.v78.10.2568.bloodjournal78102568
Autor:
F G, Schuening, R, Storb, S, Goehle, T C, Graham, R, Hackman, M, Mori, L M, Souza, F R, Appelbaum
Publikováno v:
Blood. 76:636-640
We studied whether treatment of dogs with recombinant human granulocyte colony-stimulating factor (rhG-CSF), after 920 cGy total body irradiation (TBI) and transplantation of 3.3 +/- 1.0 x 10(8) bone marrow cells per kilogram from a DLA-identical lit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7156b7f99b9425a8627af2a155111b52
https://doi.org/10.1182/blood.v76.3.636.bloodjournal763636
https://doi.org/10.1182/blood.v76.3.636.bloodjournal763636
Autor:
Motomi Mori, Friedrich Schuening, S Goehle, Robert C. Hackman, Frederick R. Appelbaum, Lawrence M. Souza, Rainer Storb, Theodore C. Graham
Publikováno v:
Blood. 76:636-640
We studied whether treatment of dogs with recombinant human granulocyte colony-stimulating factor (rhG-CSF), after 920 cGy total body irradiation (TBI) and transplantation of 3.3 +/- 1.0 x 10(8) bone marrow cells per kilogram from a DLA-identical lit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::446d34b77f27d3505f4dc0d93e9eaa6c
https://doi.org/10.1182/blood.v76.3.636.636
https://doi.org/10.1182/blood.v76.3.636.636
Autor:
Andrea L. Medina-Holguín, Sandra Micheletto, Mary A. O’Connell, Julian A. Simon, S Goehle, F. Omar Holguin
Publikováno v:
Phytochemistry. 69(4)
Anemopsis californica (Saururaceae) commonly called yerba mansa, is an important medicinal plant in many deserts in the southwestern region of North America. Populations of A. californica, collected throughout New Mexico, were examined for chemical v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c998ee6c9ef8365ca725aff660c611
https://pubmed.ncbi.nlm.nih.gov/18177907
https://pubmed.ncbi.nlm.nih.gov/18177907
Autor:
Seunghee Lee, S Goehle, Kyung-Sook Chung, Misun Won, Kwang Lae Hoe, KiHwan Bae, Dong-Uk Kim, Julian A. Simon, Hyang-Sook Yoo, Kyung-Bin Song, NamHui Yim, Kyung-Sun Hur, Hyung-Bae Kim, Shin-Jung Choi
Publikováno v:
Investigational new drugs. 26(4)
The cell-based assay using yeast deletion mutants has been recognized as an efficient analysis to discover therapeutic compounds and reveal their mode of action. In this study, S. pombe deletion mutants-based HTS screening was carried out to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db779137f0891d9c7ac671043e2bef8
https://pubmed.ncbi.nlm.nih.gov/18204818
https://pubmed.ncbi.nlm.nih.gov/18204818