Zobrazeno 1 - 10
of 346
pro vyhledávání: '"S, Gisselbrecht"'
Autor:
Kian Hong Kock, Patrick K. Kimes, Stephen S. Gisselbrecht, Sachi Inukai, Sabrina K. Phanor, James T. Anderson, Gayatri Ramakrishnan, Colin H. Lipper, Dongyuan Song, Jesse V. Kurland, Julia M. Rogers, Raehoon Jeong, Stephen C. Blacklow, Rafael A. Irizarry, Martha L. Bulyk
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) among eukaryotic sequence-specific transcription factors (TFs) and are the TF structural class with the largest number of disease-associated mutations in the Human
Externí odkaz:
https://doaj.org/article/fb03d33422b540199802faeaf082a440
Autor:
Matthew J. Stevenson, Sabrina K. Phanor, Urvi Patel, Stephen S. Gisselbrecht, Martha L. Bulyk, Lori L. O'Brien
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/4f3047bac88542cc9b27e1ea55de683f
Autor:
Colin T. Waters, Stephen S. Gisselbrecht, Yuliya A. Sytnikova, Tiziana M. Cafarelli, David E. Hill, Martha L. Bulyk
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract Understanding the contributions of transcription factor DNA binding sites to transcriptional enhancers is a significant challenge. We developed Quantitative enhancer-FACS-Seq for highly parallel quantification of enhancer activities from a g
Externí odkaz:
https://doaj.org/article/f4bb68481a69441cb27f3a3d910c8ac7
Autor:
Leila Shokri, Sachi Inukai, Antonina Hafner, Kathryn Weinand, Korneel Hens, Anastasia Vedenko, Stephen S. Gisselbrecht, Riccardo Dainese, Johannes Bischof, Edy Furger, Jean-Daniel Feuz, Konrad Basler, Bart Deplancke, Martha L. Bulyk
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 955-970.e7 (2019)
Summary: Combinatorial interactions among transcription factors (TFs) play essential roles in generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid (Y2H) assays on nearly all sequence-specific Drosophila TFs, we iden
Externí odkaz:
https://doaj.org/article/9e3550215eb148d5a27340a7e617b017
Autor:
Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke
Publikováno v:
Nucleic acids research.
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903898588356c15d0e0b5a2ffbcfa377
https://pubmed.ncbi.nlm.nih.gov/36537216
https://pubmed.ncbi.nlm.nih.gov/36537216
Autor:
Matthew Jared Stevenson, Sabrina K. Phanor, Urvi Patel, Stephen S. Gisselbrecht, Martha L. Bulyk, Lori L. O'Brien
SUMMARYWilms tumors present as an amalgam of varying proportions of three tissues normally located within the developing kidney, one being the multipotent nephron progenitor population. While incomplete differentiation of the nephron progenitors is w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e94ffa9d1ea16dfa218ab882db04cc
https://doi.org/10.1101/2022.11.02.514796
https://doi.org/10.1101/2022.11.02.514796
Autor:
Brian W Busser, Stephen S Gisselbrecht, Leila Shokri, Terese R Tansey, Caitlin E Gamble, Martha L Bulyk, Alan M Michelson
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69385 (2013)
Homeodomain (HD) proteins are a large family of evolutionarily conserved transcription factors (TFs) having diverse developmental functions, often acting within the same cell types, yet many members of this family paradoxically recognize similar DNA
Externí odkaz:
https://doaj.org/article/ae3415d4afba4ec79cbd98334d7707cd
Publikováno v:
Trends Genet
Silencers are regulatory DNA elements that reduce transcription from their target promoters; they are the repressive counterparts of enhancers. Although discovered decades ago, and despite evidence of their importance in development and disease, sile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a3711cbcbbe06d412b121d8def8bdc
https://pubmed.ncbi.nlm.nih.gov/33712326
https://pubmed.ncbi.nlm.nih.gov/33712326
Publikováno v:
Genome Res
Deciphering the interplay between chromatin accessibility and transcription factor (TF) binding is fundamental to understanding transcriptional regulation, control of cellular states, and the establishment of new phenotypes. Recent genome-wide chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db7c4b6e2197e33b26ce584c86f487c
https://pubmed.ncbi.nlm.nih.gov/32424069
https://pubmed.ncbi.nlm.nih.gov/32424069
Autor:
Anthony A Philippakis, Brian W Busser, Stephen S Gisselbrecht, Fangxue Sherry He, Beatriz Estrada, Alan M Michelson, Martha L Bulyk
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 5, p e53 (2006)
While combinatorial models of transcriptional regulation can be inferred for metazoan systems from a priori biological knowledge, validation requires extensive and time-consuming experimental work. Thus, there is a need for computational methods that
Externí odkaz:
https://doaj.org/article/15a5874a0a4a422197c9547317d96a8f