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pro vyhledávání: '"S, Gardella"'
Akademický článek
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Akademický článek
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Autor:
Heidi R. Bokesch, Jennifer A. Wilson, Curtis J. Henrich, Tanya R. Johnson, Ekaterina I. Goncharova, Kentaro Takada, James B. McMahon, Kirk R. Gustafson, Roberta S. Gardella
Publikováno v:
Chemical Biology & Drug Design. 69:321-330
Development of modulators of constitutively active, kinase domain mutants of c-Kit has proved to be very difficult. Therefore, a high-throughput differential cytotoxicity assay was developed to screen for compounds that preferentially kill cells expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f105ab5bc4133d4cde66e9d2f1fce1
https://doi.org/10.1111/j.1747-0285.2007.00508.x
https://doi.org/10.1111/j.1747-0285.2007.00508.x
Autor:
James R. Vasselli, Tawnya C. McKee, James B. McMahon, W. Marston Linehan, Roberta S. Gardella, Girma M. Woldemichael
Publikováno v:
SLAS Discovery. 11:678-687
Reporter cell lines have been developed for the identification of inhibitors of gene expression enhanced by hypoxia-inducible factor 2, which has been implicated as a transcription factor involved in the tumorigenesis of clear cell renal carcinoma. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99bfce6a920af0c6e46b36535bbd385
https://doi.org/10.1177/1087057106289234
https://doi.org/10.1177/1087057106289234
Autor:
Michael R. Boyd, Tawnya C. McKee, Gregory M. L. Patterson, Roberta S. Gardella, Lewis K. Pannell, Karen Watson, Heidi R. Bokesch, Raymond C. Sowder, Robert W. Buckheit, Barry R. O'Keefe, Jim A. Turpin
Publikováno v:
Biochemistry. 42:2578-2584
A new anti-HIV protein, scytovirin, was isolated from aqueous extracts of the cultured cyanobacterium Scytonema varium. The protein displayed potent anticytopathic activity against laboratory strains and primary isolates of HIV-1 with EC50 values ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d46ebff17598d24cdcc316104d394e7
https://doi.org/10.1021/bi0205698
https://doi.org/10.1021/bi0205698
Autor:
George R. Pettit, Sylvie Ducki, Rui Tan, Roberta S. Gardella, James B. McMahon, Michael R. Boyd, Peter M. Blumberg, Nancy E. Lewin, Dennis L. Doubek, Larry P. Tackett, Michael D. Williams
Publikováno v:
Journal of Natural Products. 65:1262-1265
A new cancer cell growth inhibitor designated pedilstatin (1) was isolated from a Republic of Maldives Pedilanthus sp. The structure was determined to be 13-O-acetyl-12-O-[2'Z,4'E-octadienoyl]-4alpha-deoxyphorbol on the basis of high-resolution mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a362597972fc67e53eeaaed72e370348
https://doi.org/10.1021/np020115b
https://doi.org/10.1021/np020115b
Autor:
Randy A. Buzzell, Barry R. O'Keefe, Danielle Robbins, Jennifer A. Wilson, James B. McMahon, Tanya R. Johnson, Michael R. Boyd, John A. Beutler, Roberta S. Gardella
Publikováno v:
SLAS Discovery. 7:105-110
The human immunodeficiency virus type-1 (HIV-1) envelope glycoprotein gp41 is an important mediator of viral entry into host cells. Previous studies showed that the virucidal protein cyanovirin-N (CV-N) bound to both gp120 and gp41, and that this bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2a8628fa59a1d420deba469e6a088a0
https://doi.org/10.1177/108705710200700202
https://doi.org/10.1177/108705710200700202
Autor:
Daniel C. Rabe, Tanja Grkovic, James B. McMahon, Kirk R. Gustafson, Emily L. Whitson, Tawnya C. McKee, W. Marston Linehan, Donald P. Bottaro, Roberta S. Gardella
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2113-2115
Kidney cancer was the cause of almost 13,000 deaths in the United States in 2009. Loss of function of the VHL tumor suppressor gene (von Hippel-Lindau disease) dramatically increases the risk of developing clear cell kidney cancer. The VHL protein is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fa500ba3dd5f9fdc029ce1d7d6264c
https://doi.org/10.1016/j.bmcl.2011.01.127
https://doi.org/10.1016/j.bmcl.2011.01.127
Autor:
Celeste Zalewski, Gerard J. McGarrity, Michele Kaloss, Roberta S. Gardella, Richard A. Del Giudice, Edward Otto
Publikováno v:
Methods in Cell Science. 18:261-268
A rapid, sensitive assay was developed that can detect the six species of Mycoplasmas that account for the vast majority of cell culture infections. This assay, a modification of the method published by Wong-Lee & Lovett [1], allows direct evaluation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e9780d97287033eb0ac3e2c03ae987
https://doi.org/10.1007/bf00127903
https://doi.org/10.1007/bf00127903