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Akademický článek

Reduction of therapeutic antibody self-association using yeast-display selections and machine learning

Autor: Emily K. Makowski, Hongwei Chen, Matthew Lambert, Eric M. Bennett, Nicole S. Eschmann, Yulei Zhang, Jennifer M. Zupancic, Alec A. Desai, Matthew D. Smith, Wenjia Lou, Amendra Fernando, Timothy Tully, Christopher J. Gallo, Laura Lin, Peter M. Tessier

Publikováno v: mAbs, Vol 14, Iss 1 (2022)

Self-association governs the viscosity and solubility of therapeutic antibodies in high-concentration formulations used for subcutaneous delivery, yet it is difficult to reliably identify candidates with low self-association during antibody discovery

Externí odkaz: https://doaj.org/article/b7a6b619288444029f50f9d427dbd60c

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Optimierung der 223Radium-Dichlorid-Therapie von Patienten mit kastrationsresistentem Prostatakarzinom und Knochenmetastasen

Autor: Thorsten D. Poeppel, S. Eschmann, L. Freudenberg, M. Dietlein, A. Werner, H. Ilhan, K. Mattes-György, B. Kläsner, I. Janssen, L. Stegger, M.-O. Möllers

Publikováno v: best practice onkologie. 16:494-506

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8921d49c056148686225cff42e3b51d
https://doi.org/10.1007/s11654-021-00341-9

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Pain efficacy with radium-223 (Ra-223) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) in the PARABO observational study

Autor: H. Palmedo, S. Eschmann, F. Straube, A. Niesen, J. Schönberger, V. Barsegian, K. Liepe, F.M. Mottaghy, R. Guan, J. Pinkert, K. Herrmann

Publikováno v: 60. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d687c737322d55d38e19a1d188b5f7eb
https://doi.org/10.1055/s-0042-1746064

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Pain response and clinical outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with radium-223 (Ra-223): Final results from a prospective, noninterventional study (PARABO)

Autor: H. Palmedo, S. Eschmann, A. Niesen, J. Schönberger, V. Barsegian, K. Liepe, F.M. Mottaghy, R. Guan, J. Pinkert, K. Herrmann

Publikováno v: 60. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afbc353bf6118c953292d47a033cbef8
https://doi.org/10.1055/s-0042-1746058

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119P Prospective trial of immuno-(chemo)therapy (IO) prior to resection, definitive chemo-radiotherapy, or palliative therapy in patients with borderline resectable non-small cell lung cancer (NSCLC) including oligometastatic disease (KOMPASSneo)

Autor: M. Faehling, K. Lehrach, S. Fallscheer, B. Schwenk, S. Kramberg, J. Sträter, S. Eschmann, M. Hetzel, F. Heinzelmann, R. Sätzler

Publikováno v: Journal of Thoracic Oncology. 18:S108

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf7592371a955d97fffc9bae529a6ab9
https://doi.org/10.1016/s1556-0864(23)00374-x

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Pain evaluation in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) treated with radium-223 (Ra-223) in the PARABO observation study

Autor: A. Benson, M.-O. Möllers, Thorsten D. Poeppel, S. Eschmann, J. Kalinovsky, H. Palmedo, A. Werner, I. Selinski

Publikováno v: 59. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin.

Background Ra-223 demonstrated a significant overall survival benefit and favourable safety profile in mCRPC in the ALSYMPCA study (Parker C et al. N Engl J Med 2013; 369:213–223). PARABO (NCT02398526) is an ongoing, prospective, observational, non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4742beebad456eed25017849ca787a35
https://doi.org/10.1055/s-0041-1726808

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594P Pain efficacy with radium-223 (Ra-223) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) in the PARABO observational study

Autor: H. Palmedo, S. Buetikofer, J. Pinkert, R. Guan, J. Schönberger, K. Liepe, A. Niesen, I. Selkinski, Felix M. Mottaghy, Ken Herrmann, V. Barsegian, F. Straube, S. Eschmann, H. Ahmadzadehfar

Publikováno v: Annals of Oncology. 32:S641

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::519efb84abb88cbc8e3cc3bb0b5cd2c9
https://doi.org/10.1016/j.annonc.2021.08.1107

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80P Prospective analysis of patients with non-small cell lung cancer (NSCLC) receiving neoadjuvant (chemo-) immunotherapy (C-IO) prior to resection or definitive radiochemotherapy (RCT) in routine clinical care (KOMPASS neo)

Autor: F. Heinzelmann, S. Fallscheer, Jörn Sträter, R. Saetzler, H. Witte, Martin Faehling, A. Türk, S. Eschmann

Publikováno v: Journal of Thoracic Oncology. 16:S739

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64352db99d37aeeb51270b7a454e0cfd
https://doi.org/10.1016/s1556-0864(21)01922-5

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Global monitoring of average volume of alcohol consumption

Autor: S Eschmann, Jürgen Rehm

Summary: Objectives: To estimate the prevalence of different categories of average volume of alcohol consumption for World Health Organization (WHO) regions. To check how the monitored indicator of average volume relates to prevalence of alcohol depe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df9923ad0cb4fc6453348646f4e4ea4
http://doc.rero.ch/record/318682/files/38_2005_Article_BF01318406.pdf

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