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P069 Design and delivery of anti-oxidant inorganic complexes mimicking the superoxide dismutase for inflammatory bowel diseases treatment

Autor: G Schanne, M Zoumpoulaki, S Demignot, N Delsuc, C Policar, P Seksik

Publikováno v: Journal of Crohn's and Colitis. 16:i175-i176

Background Oxidative stress (OS), defined by an increased flux of reactive oxygen species (ROS), plays an important role in the pathogenesis, the perpetuation and the amplification of inflammatory bowel diseases. In normal state, enzymatic defenses r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80b97ef7c2f36b7417a5d6d2b8e8ff11
https://doi.org/10.1093/ecco-jcc/jjab232.198

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[Versatility of differentiated functions of cultured joint chondrocytes. Eventual usefulness in treatment]

Autor: M, Adolphe, S, Demignot

Publikováno v: Bulletin de l'Academie nationale de medecine. 184(3)

The chondrocyte is the unique cell type in articular cartilage. It is responsible for the extracellular matrix production which permits the cartilaginous tissue to compensate the skeletal pressures during movements. The regulation of the different ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b5b2b328be728970fbbfd6115e50346
https://pubmed.ncbi.nlm.nih.gov/10989555

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Detection and characterization, using fluoresceincadaverine, of amine acceptor protein substrates accessible to active transglutaminase expressed by rabbit articular chondrocytes

Autor: M, Lajemi, S, Demignot, M, Adolphe

Publikováno v: The Histochemical journal. 30(7)

The purpose of this study was to investigate the implication of transglutaminases in the biology of articular chondrocytes. Transglutaminase activity measurements performed on cell lysates showed that a transglutaminase was present in chondrocytes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da055de05781e65ff03c8c1df9f827f7
https://pubmed.ncbi.nlm.nih.gov/10192533

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Dedifferentiated chondrocytes cultured in alginate beads: restoration of the differentiated phenotype and of the metabolic responses to interleukin-1beta

Autor: F, Lemare, N, Steimberg, C, Le Griel, S, Demignot, M, Adolphe

Publikováno v: Journal of cellular physiology. 176(2)

Chondrocytes cultivated in monolayer rapidly divide and lose their morphological and biochemical characteristics, whereas they maintain their phenotype for long periods of time when they are cultivated in alginate beads. Because cartilage has a low c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e1a0ec8b168a2cde2ffcf51a19c7539
https://pubmed.ncbi.nlm.nih.gov/9648917

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Enoxolone suppresses apoptosis in chondrocytes and progression of osteoarthritis via modulating the ERK1/2 signaling pathway.

Autor: Gang Hong¹ HermanBrucefva@yahoo.com

Publikováno v: Archives of Medical Science. Jun2024, Vol. 20 Issue 3, p947-961. 15p.

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The use of Fluoresceincadaverine for detecting amine acceptor protein substrates accessible to active transglutaminase in living cells

Autor: M, Lajemi, S, Demignot, L, Borge, S, Thenet-Gauci, M, Adolphe

Publikováno v: The Histochemical journal. 29(8)

The use of Fluoresceincadaverine as a primary amine donor for detecting the endogenous substrates for active transglutaminase in living cells was studied. Fluoresceincadaverine was found to be suitable for labelling cells in culture as it did not ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::773767634cf8208cfcef07927f194bf7
https://pubmed.ncbi.nlm.nih.gov/9347356

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