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Development and Assessment of Conventional and Targeted Drug Combinations for Use in the Treatment of Aggressive Breast Cancers

Autor: D N, Waterhouse, K A, Gelmon, R, Klasa, K, Chi, D, Huntsman, E, Ramsay, E, Wasan, L, Edwards, C, Tucker, J, Zastre, Y Z, Wang, Y Z, Zhang, D, Yapp, W, Dragowska, S, Dunn, S, Dedhar, M B, Bally

Publikováno v: Current Cancer Drug Targets. 6:455-489

Combination chemotherapy has been at the forefront of cancer treatment for over 40 years. However, the rationale for selecting drug combinations and the process used to demonstrate clinical effectiveness has primarily followed trial and error methodo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff4a09bc1d474782e15eeba78ec158d
https://doi.org/10.2174/156800906778194586

The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion

Autor: Geraldine Mbamalu, M. Rozakis-Adcock, D. Anderson, J. Settleman, Lan Bo Chen, B. Brunkhorst, S. Dedhar, J McGlade, Tony Pawson

Publikováno v: The EMBO Journal. 12:3073-3081

Ras GTPase activating protein (GAP) possesses a C-terminal domain that interacts with GTP-bound Ras, and an N-terminal region containing two SH2 domains and an SH3 domain. In addition to its association with Ras, GAP binds stably to autophosphorylate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0464b9901176eda6bc0795fc22b86ff6
https://doi.org/10.1002/j.1460-2075.1993.tb05976.x

Contents, Vol. 13, 1992

Autor: Merlene L. Benner, R. Bianchi, Mariadomenica D'Alessandro, S. von Kleist, Robert H. Whitehead, Nariaki Matsuura, Glenn D. Steele, Bengt Bergman, Xavier Filella, Jan Cejka, S. Dedhar, P.J. Hertzog, Kunio Yamasaki, Sten Hammarström, Ken Kodama, Pei-Xiang Xing, Karel Kithier, C. Prontera, S.G. Combs, Hideoki Yokouchi, Hiroaki Abe, Michio Ogawa, Gloria Borras, Stanley M. Berry, Tatsuo Sato, Osamu Doi, Naohiro Tomita, Ryuhei Tateishi, G.K. Haines, Takushi Monden, Rafael Molina, Carl-Peter Engström, Nobuhiro Takeshima, Davide Lomanto, Fred-Thomas Brezicka, Yoshinori Suminami, Hiroshi Harada, Ian F. C. McKenzie, C. Gailey, B. Thimmappaya, M. Ferdeghini, G.D. Ghadge, A.M. Neville, L.M. Lang, Peter L. Devine, T.S. Ravikumar, Darlene W. Mood, Ken-ichi Mafune, Emanuele Lezoche, Masahiko Higashiyama, Judith Jo, S.J. Pilbrow, Kazuhisa Taketa, N. Auersperg, Feng-Ming Chen, Kulvinder S. Saini, Paola Mariani, Ming Liu, Shigetoshi Fujiyama, G.D. Pinczower, Mary Phyllis Whitcomb, Antonio M. Ballesta, P. Fioretti, Atsuo Murata, Hiroshi Kato, B. Ojeda, Geoffrey W. Birrell, Lan Bo Chen, Kiyonori Izuno, G. Malagnino, Sture Larsson, Jose J. Lopez, U. Elsässer-Beile, V. Speranza, W. Leslie, A.W. Linnane, A. Gadducci, Nagato Okuno, Ernesto Mas, M. Martin, S.E. Myrdal, B. Prato, C. Annicchiarico, Håkan Berggren, Peter Thomas, Jan Holmgren, Osamu Takeda, Leif Lindholm, Francesco Carlei, J.A. Radosevich, Yu-Ling Xin, Sante Olling

Publikováno v: Tumor Biology. 13:I-V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58b8a91a89de2f9ae496339bb9b3b601
https://doi.org/10.1159/000217772

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