Zobrazeno 1 - 10
of 1 351
pro vyhledávání: '"S, De Groot"'
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 205-212 (2024)
Introduction Clinical trials of personalized cancer vaccines have shown that on-demand therapies that are manufactured for each patient, result in activated T cell responses against individual tumor neoantigens. However, their use has been traditiona
Externí odkaz:
https://doaj.org/article/c49a5329643540508e3c44e5426a9e1f
Autor:
Aimee E. Mattei, Andres H. Gutierrez, Soorya Seshadri, Jacob Tivin, Matt Ardito, Amy S. Rosenberg, William D. Martin, Anne S. De Groot
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTIn silico immunogenicity risk assessment has been an important step in the development path for many biologic therapeutics, including monoclonal antibodies. Even if the source of a given biologic is ‘fully human’, T cell epitopes that are
Externí odkaz:
https://doaj.org/article/d3ac97f35912434aae9b77e2b10534c0
Autor:
Jorik H. Amesz, Mark F. A. Bierhuizen, Sanne J. J. Langmuur, Paul Knops, Yvar P. van Steenis, Dwight Dumay, Mathijs S. van Schie, Olivier C. Manintveld, Natasja M. S. de Groot, Yannick J. H. J. Taverne
Publikováno v:
Transplant International, Vol 37 (2024)
Normothermic ex-situ heart perfusion (ESHP) enables assessment of hearts donated after circulatory death (DCD) prior to transplantation. However, sensitive parameters of cardiac function of DCD hearts on ESHP are needed. This study proposes a novel a
Externí odkaz:
https://doaj.org/article/5e91eed733db435f8c7a9550dc8dadab
Autor:
Gabe S Sonke, Amos J de Jong, Lourens T Bloem, Christine C van Hattem, Jolien S de Groot, Jarno Hoekman, K Esther Broekman, Paula B van Hennik
Publikováno v:
BMJ Open, Vol 14, Iss 11 (2024)
Objective The collection of comprehensive data from post-authorisation trials for conditionally authorised anticancer medicines is frequently delayed. This raises questions about the feasibility of post-authorisation randomised controlled trials (RCT
Externí odkaz:
https://doaj.org/article/4fe87bd87ee346fdb277817cb56dabf2
Autor:
Brian J. Roberts, Aimee E. Mattei, Kristina E. Howard, James L. Weaver, Hao Liu, Sandra Lelias, William D. Martin, Daniela Verthelyi, Eric Pang, Katie J. Edwards, Anne S. De Groot
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Advances in synthetic peptide synthesis have enabled rapid and cost-effective peptide drug manufacturing. For this reason, peptide drugs that were first produced using recombinant DNA (rDNA) technology are now being produced using solid- and liquid-p
Externí odkaz:
https://doaj.org/article/674dd4b85a844bff9f2eb55deb7c7e13
Autor:
Naonobu Sugiyama, Frances E. Terry, Andres H. Gutierrez, Toshitaka Hirano, Masato Hoshi, Yasushi Mizuno, William Martin, Shin’ichiro Yasunaga, Hiroaki Niiro, Keishi Fujio, Anne S. De Groot
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
HypothesisWhile conventional in silico immunogenicity risk assessments focus on measuring immunogenicity based on the potential of therapeutic proteins to be processed and presented by a global population-wide set of human leukocyte antigen (HLA) all
Externí odkaz:
https://doaj.org/article/d63f2dd7b89147808053eb17c4804104
Autor:
Ziliang Ye, Mathijs S. van Schie, Annejet Heida, Lianne N. van Staveren, Frank R. N. van Schaagen, Yannick J. H. J. Taverne, Natasja M. S. de Groot
Publikováno v:
Annals of Medicine, Vol 55, Iss 1, Pp 1431-1441 (2023)
AbstractBackground It is unknown which features of unipolar atrial electrogram (U-AEGM) morphology are affected by ageing and whether age-related changes in U-AEGM morphology are equally distributed throughout the right and left atria.Patients and me
Externí odkaz:
https://doaj.org/article/929fa903eb0344279103a95f0bcd3eea
Autor:
Tiffani Crippin, Karamoko Tounkara, Hayley Munir, Eliza Squibb, Caroline Piotrowski, Ousmane A. Koita, Ibrahima Teguété, Anne S. De Groot
Publikováno v:
Vaccines, Vol 12, Iss 9, p 1019 (2024)
Cervical cancer (CC) is the second most common cancer in Western Africa, accounting for 12,000 cases and 6000 deaths annually. While vaccination against human papilloma virus (HPV) and CC screenings reduce the incidence and mortality of CC in many de
Externí odkaz:
https://doaj.org/article/01e3f39e48d4439c8b6bb45c671a7602
Autor:
S. M. Shahjahan Miah, Sandra Lelias, Andres H. Gutierrez, Mitchell McAllister, Christine M. Boyle, Lenny Moise, Anne S. De Groot
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Pathogens escape host defenses by T-cell epitope mutation or deletion (immune escape) and by simulating the appearance of human T cell epitopes (immune camouflage). We identified a highly conserved, human-like T cell epitope in non-structural protein
Externí odkaz:
https://doaj.org/article/b15d41c0df4c413b9ef411ccc4ae045f
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Biologics developers are moving beyond antibodies for delivery of a wide range of therapeutic interventions. These non-antibody modalities are often based on ‘natural’ protein scaffolds that are modified to deliver bioactive sequences. Both human
Externí odkaz:
https://doaj.org/article/fb0855ea9b154b43a5269a481f59c86f