Zobrazeno 1 - 10
of 914
pro vyhledávání: '"S, Crooke"'
Autor:
John J. Marini, Lauren T. Thornton, Patricia R. M. Rocco, Luciano Gattinoni, Philip S. Crooke
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-7 (2023)
Abstract At the bedside, assessing the risk of ventilator-induced lung injury (VILI) requires parameters readily measured by the clinician. For this purpose, driving pressure (DP) and end-inspiratory static ‘plateau’ pressure ( $$P_{s}$$ P s ) of
Externí odkaz:
https://doaj.org/article/f95e3a6ebcd849889f911c84ded4b604
Autor:
Shone, Ronald
Publikováno v:
The Economic Journal, 1998 Nov 01. 108(451), 1931-1932.
Externí odkaz:
https://www.jstor.org/stable/2565883
Autor:
John Selickman, Pierre Tawfik, Philip S. Crooke, David J. Dries, Jonathan Shelver, Luciano Gattinoni, John J. Marini
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-8 (2022)
Abstract Background Chest wall loading has been shown to paradoxically improve respiratory system compliance (CRS) in patients with moderate to severe acute respiratory distress syndrome (ARDS). The most likely, albeit unconfirmed, mechanism is relie
Externí odkaz:
https://doaj.org/article/5274a346bcc44585bee8ff145c2910ed
Publikováno v:
Intensive Care Medicine Experimental, Vol 10, Iss 1, Pp 1-14 (2022)
Take home message Potentially damaging tidal energy and power distribute asymmetrically within the heterogeneous environment of the acutely injured lung. Clinician-selected flow profiles not only influence the timing of power delivery, but also spati
Externí odkaz:
https://doaj.org/article/24332d7997174826ad426a5b36329ee2
Autor:
John J. Marini, Philip S. Crooke, Pierre Tawfik, Robert L. Chatburn, David J. Dries, Luciano Gattinoni
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Background High rates of inflation energy delivery coupled with transpulmonary tidal pressures of sufficient magnitude may augment the risk of damage to vulnerable, stress-focused units within a mechanically heterogeneous lung. Apart from fl
Externí odkaz:
https://doaj.org/article/66c4350c2ab34582be860ad6775d8cfa
Autor:
Anna E. Patrick, Kayla Shoaff, Tashawna Esmond, David M. Patrick, David K. Flaherty, T Brent Graham, Philip S. Crooke, Susan Thompson, Thomas M. Aune
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In juvenile idiopathic arthritis (JIA) inflammatory T cells and their produced cytokines are drug targets and play a role in disease pathogenesis. Despite their clinical importance, the sources and types of inflammatory T cells involved remain unclea
Externí odkaz:
https://doaj.org/article/dc42e2db61734440a0adf1c18b6b5635
Publikováno v:
Current Research in Immunology, Vol 2, Iss , Pp 52-59 (2021)
Due to potential severity of disease caused by SARS-CoV-2 infection, it is critical to understand both mechanisms of viral pathogenesis as well as diversity of host responses to infection. Reduced A-to-I editing of endogenous double-stranded RNAs (ds
Externí odkaz:
https://doaj.org/article/99bdb7239733469e9ba3ce5531eb37e3
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Alu retrotransposons belong to the class of short interspersed nuclear elements (SINEs). Alu RNA is abundant in cells and its repetitive structure forms double-stranded RNAs (dsRNA) that activate dsRNA sensors and trigger innate immune responses with
Externí odkaz:
https://doaj.org/article/cba9c00726d949239c293db01b634cd7
Autor:
John, Selickman, Philip S, Crooke, Pierre, Tawfik, David J, Dries, Luciano, Gattinoni, John J, Marini
Publikováno v:
Critical Care Medicine. 50:1599-1606
Head-elevated body positioning, a default clinical practice, predictably increases end-expiratory transpulmonary pressure and aerated lung volume. In acute respiratory distress syndrome (ARDS), however, the net effect of such vertical inclination on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a635d2c6d487dc73384615d0e8446e9
https://doi.org/10.1097/ccm.0000000000005631
https://doi.org/10.1097/ccm.0000000000005631
Publikováno v:
Cancer Informatics, Vol 18 (2019)
The genome-wide identification of mutated genes is an important advance in our understanding of tumor biology, but several fundamental questions remain open. How do these genes act together to promote cancer development and, a related question, how a
Externí odkaz:
https://doaj.org/article/dc687177fb22417a8124f62e8563c2d9