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Publikováno v:
Toxicology Letters. 368:S278
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(3)
An increase in arginase activity has been associated with the pathophysiology of a number of conditions, including an impairment in nonadrenergic and noncholinergic (NANC) nerve-mediated relaxation of the gastrointestinal smooth muscle. An arginase i
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 40(2)
Vasoactive intestinal peptide (VIP) is a naturally occurring 28-amino acid peptide with a wide range of biological activities. Recent reports suggest that VIP receptors are expressed on a variety of malignant tumor cells and that the receptor density
Autor:
S, Chakder, S, Rattan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(1)
Endothelins, localized in the enteric nervous system, may play important roles in the morphogenesis of the gastrointestinal (GI) tract and in the regulation of GI motility. However, the role of endothelins in the GI sphincters, including the internal
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(2)
This study was performed in the opossum lower esophageal sphincter (LES) smooth muscle strips to determine the action of the heme oxygenase inhibitor zinc protoporphyrin IX (ZnPP IX) on the relaxant effect of vasoactive intestinal polypeptide and iso
Autor:
S, Rattan, S, Chakder
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(2)
Unlike its effects on the rest of the GI tract, the effects of pituitary adenylate cyclase-activating peptide (PACAP) on the internal anal sphincter (IAS) are not known. We examined the actions of PACAP-38 (here PACAP) and PACAP-27 on the basal IAS t
Autor:
S, Chakder, S, Rattan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(1)
Studies were performed on the internal anal sphincter (IAS) smooth muscle strips obtained from opossums (Didelphis virginiana). Isometric tension and L-arginine levels of the tissues were measured under basal conditions, in the presence of electrical
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(3)
The studies were performed in the rabbit internal anal sphincter (IAS) smooth muscle strips to examine the influence of the heme oxygenase inhibitor, [zinc protporphyrin (ZnPP IX)], on basal tone. ZnPP IX produced a concentration-dependent fall in th
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 272(3)
Nitric oxide (NO) plays a significant role in the nonadrenergic noncholinergic nerve-mediated relaxation of gastrointestinal smooth muscle. Furthermore, hemoglobin is known to avidly bind NO and inhibit the nonadrenergic noncholinergic nerve-mediated