Výsledky vyhledávání - "S, Baekkeskov"

A non-cleavable mutant of Fas ligand does not prevent neutrophilic destruction of islet transplants

Autor: S M, Kang, D, Braat, D B, Schneider, R W, O'Rourke, Z, Lin, N L, Ascher, D A, Dichek, S, Baekkeskov, P G, Stock

Publikováno v: Transplantation. 69(9)

Fas ligand (FasL) mediates apoptosis of susceptible Fas-expressing lymphocytes, and may contribute to the maintenance of peripheral tolerance. In transplantation models, however, artificial expression of FasL on cellular as well as islet transplants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67acd6e74a23ee9efd2fe97b8e89183b
https://pubmed.ncbi.nlm.nih.gov/10830216

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A dendritic cell line genetically modified to express CTLA4-IG as a means to prolong islet allograft survival

Autor: R W, O'Rourke, S M, Kang, J A, Lower, S, Feng, N L, Ascher, S, Baekkeskov, P G, Stock

Publikováno v: Transplantation. 69(7)

Dendritic cells are potent antigen-presenting cells that bind allogeneic T cells. They are thus candidates for targeting immunoregulatory molecules to the alloreactive T cell compartment and suppressing the alloimmune response.A dendritic cell line d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9de872115911a8e35f5b9c7c136c39c0
https://pubmed.ncbi.nlm.nih.gov/10798768

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Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice

Autor: Brian G. Condie, S. Baekkeskov, S. F. Kash

Publikováno v: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 31(5)

The GABA-synthesizing enzyme glutamic acid decarboxylase (GAD) is expressed in pancreatic beta-cells and GABA has been suggested to play a role in islet cell development and function. Mouse beta-cells predominantly express the larger isoform of the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d942dea9c74b00d93cbf5c31a1d2354c
https://pubmed.ncbi.nlm.nih.gov/10422732

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Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase

Autor: K, Syren, L, Lindsay, B, Stoehrer, K, Jury, F, Lühder, S, Baekkeskov, W, Richter

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 157(11)

Autoreactive islet cell Abs (ICA) accompany the pathogenic destruction of pancreatic beta cells in insulin-dependent diabetes mellitus (IDDM). Human monoclonal ICA (MICA 1-6), previously derived from a DR1/DR7-positive newly diagnosed diabetic patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::afc8c34321f1989fffe909470443ab16
https://pubmed.ncbi.nlm.nih.gov/8943434

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Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

Autor: S, Baekkeskov, H J, Aanstoot, S, Christgau, A, Reetz, M, Solimena, M, Cascalho, F, Folli, H, Richter-Olesen, P, De Camilli, P D, Camilli

Publikováno v: Scopus-Elsevier
CIÊNCIAVITAE

The pancreatic islet beta-cell autoantigen of relative molecular mass 64,000 (64K), which is a major target of autoantibodies associated with the development of insulin-dependent diabetes mellitus (IDDM) has been identified as glutamic acid decarboxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b909d3754176037f97304a8f507503a
https://pubmed.ncbi.nlm.nih.gov/1697648

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Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes

Autor: M R, Christie, D G, Pipeleers, A, Lernmark, S, Baekkeskov

Publikováno v: The Journal of biological chemistry. 265(1)

Antibodies to an Mr 64,000 protein from human or rat islets have been detected at high frequency in newly diagnosed insulin-dependent diabetic patients. In this study, we show that the antigenic and amphiphilic properties of the rat islet Mr 64,000 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f28024b86b0634544b7b13337478e592
https://pubmed.ncbi.nlm.nih.gov/2403561

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The 64-kDa Beta Cell Membrane Autoantigen and Other Target Molecules of Humoral Autoimmunity in Insulin-Dependent Diabetes Mellitus

Autor: Engilbert Sigurdsson, S Baekkeskov

Publikováno v: Current Topics in Microbiology and Immunology ISBN: 9783642757433

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43d7431c5694937428045057350aaadb
https://doi.org/10.1007/978-3-642-75741-9_8

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The 64-kDa beta cell membrane autoantigen and other target molecules of humoral autoimmunity in insulin-dependent diabetes mellitus

Autor: E, Sigurdsson, S, Baekkeskov

Publikováno v: Current topics in microbiology and immunology. 164

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a484655eb92d44eb85cf9fedd2278ca
https://pubmed.ncbi.nlm.nih.gov/2073783

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Book Review

Autor: S. Baekkeskov, B. Hansen

Publikováno v: Autoimmunity. 10:77-77

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee7f00276bdd1e9dcbfe5e4df05a23d6
https://doi.org/10.3109/08916939108997151

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