Impact of ocean vertical-mixing parameterization on Arctic sea ice and upper-ocean properties using the NEMO-SI3 model

Autor: S. Allende, A. M. Treguier, C. Lique, C. de Boyer Montégut, F. Massonnet, T. Fichefet, A. Barthélemy

Publikováno v: Geoscientific Model Development, Vol 17, Pp 7445-7466 (2024)

We evaluate the vertical turbulent-kinetic-energy (TKE) mixing scheme of the NEMO-SI3 ocean–sea-ice model in sea-ice-covered regions of the Arctic Ocean. Specifically, we assess the parameters involved in TKE mixed-layer-penetration (MLP) parameter

Externí odkaz: https://doaj.org/article/c1c0a0e6caaa4dd3ac8eddf0d0b9b3ef

Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

Autor: Julien Calderaro, Narmin Ghaffari Laleh, Qinghe Zeng, Pascale Maille, Loetitia Favre, Anaïs Pujals, Christophe Klein, Céline Bazille, Lara R. Heij, Arnaud Uguen, Tom Luedde, Luca Di Tommaso, Aurélie Beaufrère, Augustin Chatain, Delphine Gastineau, Cong Trung Nguyen, Hiep Nguyen-Canh, Khuyen Nguyen Thi, Viviane Gnemmi, Rondell P. Graham, Frédéric Charlotte, Dominique Wendum, Mukul Vij, Daniela S. Allende, Federico Aucejo, Alba Diaz, Benjamin Rivière, Astrid Herrero, Katja Evert, Diego Francesco Calvisi, Jérémy Augustin, Wei Qiang Leow, Howard Ho Wai Leung, Emmanuel Boleslawski, Mohamed Rela, Arnaud François, Anthony Wing-Hung Cha, Alejandro Forner, Maria Reig, Manon Allaire, Olivier Scatton, Denis Chatelain, Camille Boulagnon-Rombi, Nathalie Sturm, Benjamin Menahem, Eric Frouin, David Tougeron, Christophe Tournigand, Emmanuelle Kempf, Haeryoung Kim, Massih Ningarhari, Sophie Michalak-Provost, Purva Gopal, Raffaele Brustia, Eric Vibert, Kornelius Schulze, Darius F. Rüther, Sören A. Weidemann, Rami Rhaiem, Jean-Michel Pawlotsky, Xuchen Zhang, Alain Luciani, Sébastien Mulé, Alexis Laurent, Giuliana Amaddeo, Hélène Regnault, Eleonora De Martin, Christine Sempoux, Pooja Navale, Maria Westerhoff, Regina Cheuk-Lam Lo, Jan Bednarsch, Annette Gouw, Catherine Guettier, Marie Lequoy, Kenichi Harada, Pimsiri Sripongpun, Poowadon Wetwittayaklang, Nicolas Loménie, Jarukit Tantipisit, Apichat Kaewdech, Jeanne Shen, Valérie Paradis, Stefano Caruso, Jakob Nikolas Kather

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

Abstract Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICCA). Combined hepatocellular- cholangiocarcinomas (cHCC-CCA) exhibit equivocal

Externí odkaz: https://doaj.org/article/ba65186be9624b389ea48c3c89596cfd

Phosphoproteomics identifies pathways underlying the role of receptor‐interaction protein kinase 3 in alcohol‐associated liver disease and uncovers apoptosis signal‐regulating kinase 1 as a target

Autor: Vaibhav Singh, Emily Huang, Vai Pathak, Belinda B. Willard, Daniela S. Allende, Laura E. Nagy

Publikováno v: Hepatology Communications, Vol 6, Iss 8, Pp 2022-2041 (2022)

Abstract Receptor‐interaction protein kinase 3 (RIP3), a critical determinant of the necroptotic pathway of programmed cell death, contributes to injury in murine models of alcohol‐associated liver disease (ALD); however, the underlying mechanism

Externí odkaz: https://doaj.org/article/974b328ba1bd4c6faf9e36f297f4cc24

The second Mexican consensus on hepatocellular carcinoma. Part II: Treatment

Autor: L.E. Cisneros-Garza, M.S. González-Huezo, C. Moctezuma-Velázquez, L. Ladrón de Guevara-Cetina, M. Vilatobá, I. García-Juárez, R. Alvarado-Reyes, G.A. Álvarez-Treviño, S. Allende-Pérez, L. Bornstein-Quevedo, G. Calderillo-Ruiz, M.A. Carrillo-Martínez, M. Castillo-Barradas, E. Cerda-Reyes, J.A. Félix-Leyva, J.A. Gabutti-Thomas, J. Guerrero-Ixtlahuac, F. Higuera-de la Tijera, D. Huitzil-Melendez, E. Kimura-Hayama, P.A. López-Hernández, R. Malé-Velázquez, N. Méndez-Sánchez, M.A. Morales-Ruiz, E. Ruíz-García, J.F. Sánchez-Ávila, L. Torrecillas-Torres

Publikováno v: Revista de Gastroenterología de México (English Edition), Vol 87, Iss 3, Pp 362-379 (2022)

Hepatocellular carcinoma (HCC) is more frequently manifesting as one of the main complications of cirrhosis of the liver, its principal risk factor. There have been modifications in its incidence over the past decade, related to an epidemiologic tran

Externí odkaz: https://doaj.org/article/3c292f56e3c14cde8b8b91d4cf4805ee

MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis

Autor: William J. Massey, Venkateshwari Varadharajan, Rakhee Banerjee, Amanda L. Brown, Anthony J. Horak, Rachel C. Hohe, Bryan M. Jung, Yunguang Qiu, E. Ricky Chan, Calvin Pan, Renliang Zhang, Daniela S. Allende, Belinda Willard, Feixiong Cheng, Aldons J. Lusis, J. Mark Brown

Publikováno v: Journal of Lipid Research, Vol 64, Iss 4, Pp 100349- (2023)

We previously demonstrated that antisense oligonucleotide-mediated knockdown of Mboat7, the gene encoding membrane bound O-acyltransferase 7, in the liver and adipose tissue of mice promoted high fat diet-induced hepatic steatosis, hyperinsulinemia,

Externí odkaz: https://doaj.org/article/4c86927b018244dab52502931112ad14