Optimal Paradigms for Quantitative Modeling in Systems Biology Demonstrated for Spinal Motor Neuron Synthesis

Autor: Gülbahar Akgün, Rza Bashirov

Publikováno v: Applied Sciences, Vol 14, Iss 22, p 10696 (2024)

Since the 1990s, Petri nets have been used in systems biology for quantitative modeling. Despite the increasing number of models developed during this period, doubts remain about their biological relevance. Although biological systems predominantly e

Externí odkaz: https://doaj.org/article/2ffe1d992b22400e968fe72c29273932

Comparison of modelling approaches demonstrated for p16-mediated signalling pathway in higher eukaryotes

Autor: Rza Bashirov, Nimet İlke Akçay

Publikováno v: Biosystems. 210:104562

Quantitative modelling of biological systems using Petri net technologies has experienced renaissance in the past couple of decades. The overwhelming majority of these models is deterministic though underlying biological systems are usually at the me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fc28811fd2266912ed174119c63955
https://doi.org/10.1016/j.biosystems.2021.104562

Simulation-based identification of optimal combination of drug candidates for spinal muscular atrophy

Autor: Recep Duranay, Adil Seytanoglu, Rza Bashirov

Publikováno v: Procedia Computer Science. 120:253-259

Spinal Muscular Atrophy is the second leading genetic cause of infant mortality. Homozygous absence of the Survival Motor Neuron 1 gene is the cause of Spinal Muscular Atrophy, while Spinal Muscular Atrophy severity is mainly determined by the number

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4c9865f427d6043861c57f44800ae13
https://doi.org/10.1016/j.procs.2017.11.236

Target-based drug discovery for [Formula: see text]-globin disorders: drug target prediction using quantitative modeling with hybrid functional Petri nets

Autor: Mani, Mehraei, Rza, Bashirov, Şükrü, Tüzmen

Publikováno v: Journal of bioinformatics and computational biology. 14(5)

Recent molecular studies provide important clues into treatment of [Formula: see text]-thalassemia, sickle-cell anaemia and other [Formula: see text]-globin disorders revealing that increased production of fetal hemoglobin, that is normally suppresse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c1f2cf00b7e65c330f3acfa1d38e14f8
https://pubmed.ncbi.nlm.nih.gov/27431020

Exploiting colored Petri nets to decide on permutation admissibility

Autor: Fabrice Kordon, Rza Bashirov, Hüseyin Lort

Publikováno v: Acta Informatica
Acta Informatica, Springer Verlag, 2009, 46 (1), pp.43-55. ⟨10.1007/s00236-008-0084-1⟩
Acta Informatica, 2009, 46 (1), pp.43-55. ⟨10.1007/s00236-008-0084-1⟩

In this work, we propose an innovative approach to investigate the admissibility of permutations to multistage interconnection networks — a challenging problem of switching theory. The proposed approach is centered upon modeling of multistage inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b919dc97acbb1a38d1aad85b0528ace9
https://hdl.handle.net/11129/1996