Výsledky vyhledávání - "Ryvkin, A. M."

Report

Temperature effect on the cardiac ryanodine receptor gating and conductance: mathematical modelling

Autor: Moskvin, A. S., Iaparov, B. I., Ryvkin, A. M., Solovyova, O. E.

Publikováno v: Biophysics, 2016, Vol. 61, No. 4, pp. 614-621

The temperature effect on the cardiac ryanodine receptor (RyR) function has been studied within the electron-conformational (EC) model. It is shown that simple EC model with the Arrhenius like temperature dependence of "internal" and "external" frict

Externí odkaz: http://arxiv.org/abs/2109.05304

Zobrazit plný text záznamu

Akademický článek

Calcium Sparks in Cardiac Pacemaker Cells at Different Temperatures in silico.

Autor: Ryvkin, A. M.^1,2 (AUTHOR) a.m.ryvkin@gmail.com, Markov, N. S.^2,3 (AUTHOR), Yudenko, V.⁴ (AUTHOR)

Publikováno v: Journal of Evolutionary Biochemistry & Physiology. 2022 Suppl, Vol. 58, pS125-S133. 9p.

Zobrazit plný text záznamu

Report

Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

Autor: Moskvin, A. S., Ryvkin, A. M., Solovyova, O. E., Markhasin, V. S.

Publikováno v: Pis'ma v ZhETP (JETP Lett.), 93 (7), 446-452 (2011)

We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal phy

Externí odkaz: http://arxiv.org/abs/1103.6109

Zobrazit plný text záznamu

MODELING OF THE EFFECT OF INHIBITORS OF ION CHANNELS ON THE FUNCTIONING OF CARDIAC PACEMAKERS

Autor: Budeeva, E. A., Ryvkin, A. M.

Via the integrated model, that includes electron-conformational model of stochastic dynamics of ryanodine RyR channels (ECM) and Ca2+-releasing model, effect of various inhibitors of ion channels (ryanodine, lidocaine, nifedipine) on the frequency of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______917::9e09d91c7a347338725c0b43ac2257b5
http://elar.urfu.ru/handle/10995/110068

Zobrazit plný text záznamu

MODIFICATION OF RYANODINE-SENSITIVE CALCIUM RELEASE CHANNELS GATING AND CALCIUM DYNAMICS IN CARDIOMYOCYTES BY TEMPERATURE IN ELECTRON-CONFORMATIONAL THEORY

Autor: Yaparov, B. Ya., Moskvin, A. S., Ryvkin, A. M.

We took into account a temperature in an Electron-Conformational Model of SR-based Ca2+ Clock (ECM Clock). The results of modelling of ECM Clock show that higher temperature gives lower amplitude of cytosolic Ca2+ and higher frequency of oscillations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______917::65ccf9eecf2ed5f66d6bd7e9f88a4d7e
https://hdl.handle.net/10995/105338

Zobrazit plný text záznamu