Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ryuzo Yoshioka"'
Autor:
Bunta Watanabe, Saki Minami, Hideaki Ishida, Ryuzo Yoshioka, Yoshiaki Nakagawa, Tsuyoshi Morita, Ken'ichiro Hayashi
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136242 (2015)
CCG-1423 suppresses several pathological processes including cancer cell migration, tissue fibrosis, and the development of atherosclerotic lesions. These suppressions are caused by inhibition of myocardin-related transcription factor A (MRTF-A), whi
Externí odkaz:
https://doaj.org/article/e9142a1391e04943b6d71f54b12d8121
Publikováno v:
Journal of Chemical Technology and Biotechnology. 29:145-148
Existing methods for prepaiing pure L-leucine from protein hydrolysates are unsatisfactory, especially when L-leucine, isoleucine-free, is required in high purity. Using a commercial crude leucine containing 73% of L-leucine, 10% of L-isoleucine and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65c7b4ab00c9c6764d61d55d2404215e
https://doi.org/10.1002/jctb.503290304
https://doi.org/10.1002/jctb.503290304
Autor:
Tsuyoshi Morita, Saki Minami, Hideaki Ishida, Bunta Watanabe, Yoshiaki Nakagawa, Ryuzo Yoshioka, Ken-ichiro Hayashi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 8, p e0136242 (2015)
PLoS ONE, Vol 10, Iss 8, p e0136242 (2015)
CCG-1423 suppresses several pathological processes including cancer cell migration, tissue fibrosis, and the development of atherosclerotic lesions. These suppressions are caused by inhibition of myocardin-related transcription factor A (MRTF-A), whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0199c0e108a3fccf5f5012f9097035
https://pubmed.ncbi.nlm.nih.gov/26295164
https://pubmed.ncbi.nlm.nih.gov/26295164
Autor:
Ryuzo, Yoshioka, Kazuo, Matsumoto
Publikováno v:
Yakushigaku zasshi. 49(1)
In this paper, the writers reviewed in detail the pharmaceutical market and the shifts in manufacturing and sales including the trade balance in Japan over a thirty-year period from 1980 to 2010. From the 1980s to the 1990s, many innovative pharmaceu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::400839a13ceade51f1c1e6633eac9b8e
https://pubmed.ncbi.nlm.nih.gov/25272638
https://pubmed.ncbi.nlm.nih.gov/25272638
Publikováno v:
Yakushigaku zasshi. 49(1)
In 1970s, the material patent system was introduced in Japan. Since then, many Japanese pharmaceutical companies have endeavored to create original in-house products. From 1980s, many of the innovative products were small molecular drugs and were dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4eeeef8ecdd23419765c1298b73dc6c9
https://pubmed.ncbi.nlm.nih.gov/25272636
https://pubmed.ncbi.nlm.nih.gov/25272636
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :2121-2128
The experimentally-optimized optical resolution of DL-phenylglycine (PG) with (1S)-(+)-camphor-10-sulfonic acid ((+)-CS) afforded the crystalline D-PG·(+)-CS salt in 45.7% isolated yield and 98.8% optical purity. This excellent resolution has been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4aa13270c7b6213651e86c931407740
https://doi.org/10.1039/b003068f
https://doi.org/10.1039/b003068f
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:146-150
An effective new route to diltiazem, a representative coronary vasodilator, through (-)-(2R, 3S)-3-(4-methoxyphenyl)glycidamide [(-)-2] has been achieved. The glycidamide (-)-2 was prepared in 43% overall yield by a combination of the enzymatic resol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f51de86ef6ec4726998a1ea102e0028f
https://doi.org/10.1248/cpb.47.146
https://doi.org/10.1248/cpb.47.146
Publikováno v:
Bulletin of the Chemical Society of Japan. 71:1109-1116
In the optical resolution by diasteromeric salt formation of DL-leucine with (S)-(−)-1-phenylethanesulfonic acid (PES), the less-soluble L-Leu·(−)-PES salt preferentially crystallized from acetonitrile–methanol and, in contrast, the same resol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6ceaab00b493933722b9c9ed8c7c52a
https://doi.org/10.1246/bcsj.71.1109
https://doi.org/10.1246/bcsj.71.1109
Autor:
Ryuzo, Yoshioka
Publikováno v:
Topics in current chemistry. 269
Tanabe Seiyaku has been investigating an efficient optical resolution method for the productionof optically active amino acids since the 1950s. As one of the practical applications of the resolutionmethods, we focused on crystallization-induced asymm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::61bf608ee8cac40d0b132da7e0453494
https://pubmed.ncbi.nlm.nih.gov/23605350
https://pubmed.ncbi.nlm.nih.gov/23605350
Autor:
Hiroyasu Seko, Ryuzo Yoshioka, Yasuhiko Ozaki, Tadashi Nakatani, Katsuji Morimatsu, Yoshikazu Mori, Shinichi Yamada, Yoshinori Ishizu
Publikováno v:
The Journal of Organic Chemistry. 61:8586-8590
A key intermediate of diltiazem synthesis, (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one [(2S,3S)-1], has been efficiently synthesized by an asymmetric reduction of the prochiral ketone, 2-(4-methoxyphenyl)-1,5-benzot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::562c1f822245c2ee5449f854e7b5c614
https://doi.org/10.1021/jo960950w
https://doi.org/10.1021/jo960950w