Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Ryutaro, Komuro"'
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 296:E1326-E1334
Oxidative stress plays an important role in obesity-related metabolic diseases. Glutathione peroxidase (GPX) is an antioxidant enzyme downregulated in adipose tissue of obese mice. However, the role of GPX in adipocytes remains elusive. The objective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7789085599f4e5bcf08271a2b7ef1feb
https://doi.org/10.1152/ajpendo.90921.2008
https://doi.org/10.1152/ajpendo.90921.2008
Autor:
Yuki Nakayama, Ryutaro Komuro, Yugo Miyata, Morihiro Matsuda, Atsunori Fukuhara, Manabu Abe, Hironori Kobayashi, Iichiro Shimomura
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 28:871-877
Objectives— Macrophage-mediated chronic inflammation of adipose tissue is causally linked to insulin resistance in obesity. The beneficial effects of 3-hydroxy-3-methylglutaryl (HMG) coenzyme A (CoA) reductase inhibitors (statins) on glucose metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c365237e743786ffc4e60fafb97c84
https://doi.org/10.1161/atvbaha.107.160663
https://doi.org/10.1161/atvbaha.107.160663
Publikováno v:
Biochemical and Biophysical Research Communications. 365:826-832
Adipocyte secretes bioactive proteins called adipocytokines, and biosynthesis of secretory proteins requires molecular chaperones and folding enzymes in endoplasmic reticulum (ER). ER chaperones are known to be induced by unfolded protein response (U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71dcbf560fe14b3ba5eef85f2a6f083f
https://doi.org/10.1016/j.bbrc.2007.11.045
https://doi.org/10.1016/j.bbrc.2007.11.045
Autor:
Tohru Funahashi, Toshiyuki Takagi, Iichiro Shimomura, Muriel J. Caslake, Atsunori Fukuhara, Hironori Kobayashi, Manabu Abe, Morihiro Matsuda, Alex D. McMahon, James Shepherd, Ryutaro Komuro, Shinji Kihara
Publikováno v:
Atherosclerosis. 196:114-121
In the West of Scotland Coronary Prevention Study (WOSCOPS), treatment of hypercholesterolemic men with pravastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, reduced their likelihood to progress to diabetes mellitus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5eb745e256a6db357cbe9091f41945
https://doi.org/10.1016/j.atherosclerosis.2007.02.013
https://doi.org/10.1016/j.atherosclerosis.2007.02.013
Autor:
Yugo Miyata, Yoshihiro Tochino, Iichiro Shimomura, Sachiyo Tanaka, Kazuya Oshima, Naomi Hosogai, Atsunori Fukuhara, Ryutaro Komuro, Shigetada Furukawa, Katsumori Segawa, Morihiro Matsuda
Publikováno v:
Diabetes. 56:901-911
Obesity is linked to a variety of metabolic disorders, such as insulin resistance and atherosclerosis. Dysregulated production of fat-derived secretory factors, adipocytokines, is partly responsible for obesity-linked metabolic disorders. However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a5b925ae29ab332d0ef0d9e1d6c4db
https://doi.org/10.2337/db06-0911
https://doi.org/10.2337/db06-0911
Autor:
Tetsuya Shimizugawa, Shizuya Yamashita, Mitsuru Shimamura, Ryutaro Komuro, Takafumi Kohama, Tatsuo Ishida, Kazuaki Kotani, Keita Kono, Hiroaki Yasumo, Ken-ichi Hirata, Naohiko Sakai, Yosuke Ando, Iichiro Shimomura, Mitsuyo Okazaki, Hidehiko Furukawa, Kazunori Fujimoto, Ryuta Koishi, Morihiro Matsuda
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 27:366-372
Objectives— A low level of high-density lipoprotein (HDL) in plasma has been recognized as an aspect of metabolic syndrome and as a crucial risk factor of cardiovascular events. However, the physiological regulation of plasma HDL levels has not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46e3b8852f8a0702dfb168bb1645d66
https://doi.org/10.1161/01.atv.0000252827.51626.89
https://doi.org/10.1161/01.atv.0000252827.51626.89
Autor:
Atsunori Fukuhara, Yosuke Okuno, Katsumori Segawa, Yasuhiko Nakagawa, Tohru Funahashi, Naomi Hosogai, Morihiro Matsuda, Ryutaro Komuro, Shinji Kihara, Kentaro Morita, Masaki Tanaka, Iichiro Shimomura
Publikováno v:
Biochemical and Biophysical Research Communications. 349:875-882
Obesity is associated with metabolic disorders, such as insulin resistance. Visfatin is an adipose-derived secretory factor to exert insulin-mimetic effects. Plasma visfatin levels and mRNA levels of visfatin in adipose tissues are increased in obesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be7a08c0bc670a895846633de743c71
https://doi.org/10.1016/j.bbrc.2006.07.083
https://doi.org/10.1016/j.bbrc.2006.07.083
Autor:
Ryutaro Komuro, Yoshio Oda, Katsuji Kobayashi, Kaoru Sugimori, Masao Shimazaki, Yoshifumi Koshino, Katsuaki Satou
Publikováno v:
Psychogeriatrics. 6:74-78
We report a 57-year-old patient with Creutzfeldt-Jakob disease that initially presented with right parietal lobe syndrome. He featured early dystonic and hemiparetic posture of the left upper limb, finger agnosia, geographic disorientation and acalcu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::307aaec37937fc218ecc5d2a44de040e
https://doi.org/10.1111/j.1479-8301.2006.00154.x
https://doi.org/10.1111/j.1479-8301.2006.00154.x
Autor:
Ken-ichi Hirano, Akifumi Matsuyama, Ryutaro Komuro, Naohiko Sakai, Shizuya Yamashita, Fumihiko Matsuura, Tohru Ohama, Tadashi Nakamura, Masahiro Koseki, Kenichi Tsujii, Hisatoyo Hiraoka, Makoto Nishida
Publikováno v:
Metabolism. 54:1095-1101
We experienced a family with novel massive tendon xanthomatosis which can be excluded from known disease causing xanthomatosis. The proband was a 58-year-old man who had necrosis in his massive Achilles tendon xanthoma. Three of 5 brothers including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb1e4eac7bda71a90bba31b0ec3174b
https://doi.org/10.1016/j.metabol.2005.03.014
https://doi.org/10.1016/j.metabol.2005.03.014
Publikováno v:
Proceedings of the National Academy of Sciences. 100:3155-3160
Insig-1 and -2 are closely related proteins of the endoplasmic reticulum (ER) that block proteolytic activation of sterol regulatory element-binding proteins (SREBPs), transcription factors that activate the synthesis of cholesterol and fatty acids i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9df7a3bc74655f379f7a4a3a54c0882
https://doi.org/10.1073/pnas.0130116100
https://doi.org/10.1073/pnas.0130116100