Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Ryutaro, Fukumura"'
Autor:
Keiichi Hatakeyama, Koji Muramatsu, Takeshi Nagashima, Hiroyuki Ichida, Yuichi Kawanishi, Ryutaro Fukumura, Keiichi Ohshima, Yuji Shimoda, Sumiko Ohnami, Shumpei Ohnami, Koji Maruyama, Akane Naruoka, Hirotsugu Kenmotsu, Kenichi Urakami, Yasuto Akiyama, Takashi Sugino, Ken Yamaguchi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract The detection of copy number variations (CNVs) and somatic mutations in cancer is important for the selection of specific drugs for patients with cancer. In cancers with sporadic tumor cells, low tumor content prevents the accurate detection
Externí odkaz:
https://doaj.org/article/3803f9f730f74fb287285c07c11200a5
Autor:
Keiichi Hatakeyama, Koji Muramatsu, Takeshi Nagashima, Yuichi Kawanishi, Ryutaro Fukumura, Keiichi Ohshima, Yuji Shimoda, Hirotsugu Kenmotsu, Tohru Mochizuki, Kenichi Urakami, Yasuto Akiyama, Takashi Sugino, Ken Yamaguchi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Targeted sequencing offers an opportunity to select specific drugs for cancer patients based on alterations in their genome. However, accurate sequencing cannot be performed in cancers harboring diffuse tumor cells because of low tumor conte
Externí odkaz:
https://doaj.org/article/6695e80cba474b6392ca70861efa1b00
Autor:
Daiki Hashimoto, Kota Fujimoto, Shin Morioka, Shinya Ayabe, Tomoya Kataoka, Ryutaro Fukumura, Yuko Ueda, Mizuki Kajimoto, Taiju Hyuga, Kentaro Suzuki, Isao Hara, Shinichi Asamura, Shigeharu Wakana, Atsushi Yoshiki, Yoichi Gondo, Masaru Tamura, Takehiko Sasaki, Gen Yamada
Publikováno v:
Reproductive Medicine and Biology, Vol 21, Iss 1, Pp n/a-n/a (2022)
Abstract Purpose Penile research is expected to reveal new targets for treatment and prevention of the complex mechanisms of its disorder including erectile dysfunction (ED). Thus, analyses of the molecular processes of penile ED and continuous erect
Externí odkaz:
https://doaj.org/article/fafb6d75dc0a4fc390749b9dba681422
Autor:
Bin Li, Tao Qing, Jinhang Zhu, Zhuo Wen, Ying Yu, Ryutaro Fukumura, Yuanting Zheng, Yoichi Gondo, Leming Shi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The mouse has been widely used as a model organism for studying human diseases and for evaluating drug safety and efficacy. Many diseases and drug effects exhibit tissue specificity that may be reflected by tissue-specific gene-expression pr
Externí odkaz:
https://doaj.org/article/c86c0d74c7b24470ac896a14ef43ac92
Autor:
Arikuni Uchimura, Hirotaka Matsumoto, Yasunari Satoh, Yohei Minakuchi, Sayaka Wakayama, Teruhiko Wakayama, Mayumi Higuchi, Masakazu Hashimoto, Ryutaro Fukumura, Atsushi Toyoda, Yoichi Gondo, Takeshi Yagi
Publikováno v:
Genome Research.
De novo mutations accumulate with zygotic cell divisions. However, the occurrence of these mutations and the way they are inherited by somatic cells and germ cells remain unclear. Here, we present a novel method to reconstruct cell lineages. We ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5822004c3f7caff048288fbdab9631c8
https://doi.org/10.1101/gr.276363.121
https://doi.org/10.1101/gr.276363.121
Autor:
Shigeru Makino, Olena Zhulyn, Rong Mo, Vijitha Puviindran, Xiaoyun Zhang, Takuya Murata, Ryutaro Fukumura, Yuichi Ishitsuka, Hayato Kotaki, Daisuke Matsumaru, Shunsuke Ishii, Chi-Chung Hui, Yoichi Gondo
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119455 (2015)
Hedgehog signaling is primarily transduced by two transcription factors: Gli2, which mainly acts as a full-length activator, and Gli3, which tends to be proteolytically processed from a full-length form (Gli3FL) to an N-terminal repressor (Gli3REP).
Externí odkaz:
https://doaj.org/article/5366ddfafc8c445db67a20a837d067f6
Autor:
Keiichi Hatakeyama, Koji Muramatsu, Takeshi Nagashima, Yuichi Kawanishi, Ryutaro Fukumura, Keiichi Ohshima, Yuji Shimoda, Hirotsugu Kenmotsu, Tohru Mochizuki, Kenichi Urakami, Yasuto Akiyama, Takashi Sugino, Ken Yamaguchi
Publikováno v:
Scientific reports. 12(1)
Targeted sequencing offers an opportunity to select specific drugs for cancer patients based on alterations in their genome. However, accurate sequencing cannot be performed in cancers harboring diffuse tumor cells because of low tumor content. We pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc51c85fae32d5474a826d6df7d7997
https://pubmed.ncbi.nlm.nih.gov/35194076
https://pubmed.ncbi.nlm.nih.gov/35194076
Autor:
Nobuyasu Oiji, Long Guo, Yuriko Sato, Manami Tsukamoto, Shiro Ikegawa, Tatsuya Furuichi, Kentaro Tomii, Masaki Saito, Ryutaro Fukumura, Yoichi Gondo, Yu Yamamori, Kazuhiro Yagami
Publikováno v:
Mammalian Genome. 30:329-338
Cysteine-rich transmembrane bone morphogenetic protein regulator 1 (CRIM1) is a type I transmembrane protein involved in the organogenesis of many tissues via its interactions with growth factors including BMP, TGF-β, and VEGF. In this study, we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0da86d11bf11ffaa485a74fbbd39d99
https://doi.org/10.1007/s00335-019-09822-3
https://doi.org/10.1007/s00335-019-09822-3
Autor:
Shiro Ikegawa, Tatsuya Furuichi, Satoki Ichimura, Ryutaro Fukumura, Yoichi Gondo, Takuya Murata, Shun Sasaki
Publikováno v:
Experimental Animals. 66:137-144
Camurati-Engelmann disease (CED) is a rare sclerosing bone disorder in humans with autosomal dominant inheritance. Mutations in the gene (TGFB1) that encodes transforming growth factor-β1 (TGF-β1) are causative for CED. TGF-β1 signaling is enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28d1c8c26f026aa530822a57b6a46deb
https://doi.org/10.1538/expanim.16-0085
https://doi.org/10.1538/expanim.16-0085
Autor:
Tatsuya, Furuichi, Manami, Tsukamoto, Masaki, Saito, Yuriko, Sato, Nobuyasu, Oiji, Kazuhiro, Yagami, Ryutaro, Fukumura, Yoichi, Gondo, Long, Guo, Shiro, Ikegawa, Yu, Yamamori, Kentaro, Tomii
Publikováno v:
Mammalian genome : official journal of the International Mammalian Genome Society. 30(11-12)
Cysteine-rich transmembrane bone morphogenetic protein regulator 1 (CRIM1) is a type I transmembrane protein involved in the organogenesis of many tissues via its interactions with growth factors including BMP, TGF-β, and VEGF. In this study, we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5cfd62139f7fc7653cb99bb12d6813f
https://pubmed.ncbi.nlm.nih.gov/31776724
https://pubmed.ncbi.nlm.nih.gov/31776724