Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ryuta Koishi"'
Publikováno v:
Heliyon, Vol 5, Iss 3, Pp e01292- (2019)
Fat storage-inducing transmembrane proteins 1 and 2 (FITM1 and FITM2, respectively) are transmembrane endoplasmic/sarcoplasmic reticulum proteins involved in lipid droplet formation. The physiological functions of FITM1 have only been reported in ske
Externí odkaz:
https://doaj.org/article/25ec43e98c2a4a5792875bf8a51dcb06
Autor:
Yosuke Ando, Tetsuya Shimizugawa, Shigehito Takeshita, Mitsuru Ono, Mitsuru Shimamura, Ryuta Koishi, Hidehiko Furukawa
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 6, Pp 1216-1223 (2003)
KK/Snk mice (previously KK/San) possessing a recessive mutation (hypl) of the angiopoietin-like 3 (Angptl3) gene homozygously exhibit a marked reduction of VLDL due to the decreased Angptl3 expression. Recently, we proposed that Angptl3 is a new clas
Externí odkaz:
https://doaj.org/article/ef70bc6f8cc7446198d5a12daad3b730
Autor:
Narayan Karanjule, Noriyuki Hayashi, Sayaka Suzuki, Toshifumi Tsuda, Eri Tokumaru, Kyosuke Tanaka, Hiroko Kimoto, Yuki Domon, Sakiko Takahashi, Kazufumi Kubota, Yutaka Kitano, Tomihisa Yokoyama, Ryuta Koishi, Chie Fujiwara, Shinichi Inaba, Daigo Asano, Tomoko Sakakura, Kiyoshi Takasuna, Tsuyoshi Shinozuka
Publikováno v:
ACS Medicinal Chemistry Letters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dd20a57b9a34b89d6090c1968a55466
https://doi.org/10.1021/acsmedchemlett.3c00079
https://doi.org/10.1021/acsmedchemlett.3c00079
Autor:
Yutaka Kitano, Chie Fujiwara, Sayaka Suzuki, Ryuta Koishi, Tomihisa Yokoyama, Satoshi Shibuya, Daigo Asano, Yuki Domon, Kyosuke Tanaka, Hiroko Kimoto, Akiko Shimizugawa, Tsuyoshi Shinozuka, Kazufumi Kubota, Hiroyuki Kobayashi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:653-663
The discovery of a novel class of state-dependent voltage-gated sodium channel (NaV)1.7 inhibitors is described. By the modification of amide or urethane bond in NaV1.7 blocker III, structure-activity relationship studies that led to the identificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89845e45af2cb38ea79da89f3f6a10c8
https://doi.org/10.1248/cpb.c20-00126
https://doi.org/10.1248/cpb.c20-00126
Autor:
Tomihisa Yokoyama, Sakiko Takahashi, Kiyoshi Takasuna, Noriyuki Hayashi, Hiroyuki Kobayashi, Ryuta Koishi, Chie Fujiwara, Eri Tokumaru, Yasuyuki Abe, Kyosuke Tanaka, Sayaka Suzuki, Kazufumi Kubota, Daigo Asano, Narayan Karanjule, Tsuyoshi Shinozuka, Masahiro Inoue, Hiroko Kimoto, Tsuda Toshifumi, Yutaka Kitano, Kiyono Ueda, Toshiyuki Watanabe, Yuki Domon, Tomoko Sakakura, Akiko Shimizugawa
Publikováno v:
Journal of Medicinal Chemistry. 63:10204-10220
A highly potent, selective NaV1.7 inhibitor, DS-1971a, has been discovered. Exploration of the left-hand phenyl ring of sulfonamide derivatives (I and II) led to the discovery of novel series of cycloalkane derivatives with high NaV1.7 inhibitory pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dfbfcf9264e87757e4b9e81ee00d139
https://doi.org/10.1021/acs.jmedchem.0c00259
https://doi.org/10.1021/acs.jmedchem.0c00259
Autor:
Kyosuke, Tanaka, Hiroyuki, Kobayashi, Sayaka, Suzuki, Satoshi, Shibuya, Hiroko, Kimoto, Yuki, Domon, Kazufumi, Kubota, Yutaka, Kitano, Tomihisa, Yokoyama, Akiko, Shimizugawa, Ryuta, Koishi, Chie, Fujiwara, Daigo, Asano, Tsuyoshi, Shinozuka
Publikováno v:
Chemicalpharmaceutical bulletin. 68(7)
The discovery of a novel class of state-dependent voltage-gated sodium channel (Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::033cc77c13c4c442b3167b8a41485a0e
https://pubmed.ncbi.nlm.nih.gov/32612000
https://pubmed.ncbi.nlm.nih.gov/32612000
Autor:
Tsuyoshi, Shinozuka, Hiroyuki, Kobayashi, Sayaka, Suzuki, Kyosuke, Tanaka, Narayan, Karanjule, Noriyuki, Hayashi, Toshifumi, Tsuda, Eri, Tokumaru, Masahiro, Inoue, Kiyono, Ueda, Hiroko, Kimoto, Yuki, Domon, Sakiko, Takahashi, Kazufumi, Kubota, Tomihisa, Yokoyama, Akiko, Shimizugawa, Ryuta, Koishi, Chie, Fujiwara, Daigo, Asano, Tomoko, Sakakura, Kiyoshi, Takasuna, Yasuyuki, Abe, Toshiyuki, Watanabe, Yutaka, Kitano
Publikováno v:
Journal of medicinal chemistry. 63(18)
A highly potent, selective Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79add99460610a6681f6e61187542eaa
https://pubmed.ncbi.nlm.nih.gov/32392056
https://pubmed.ncbi.nlm.nih.gov/32392056
Publikováno v:
Heliyon, Vol 5, Iss 3, Pp e01292-(2019)
Heliyon
Heliyon
Fat storage-inducing transmembrane proteins 1 and 2 (FITM1 and FITM2, respectively) are transmembrane endoplasmic/sarcoplasmic reticulum proteins involved in lipid droplet formation. The physiological functions of FITM1 have only been reported in ske
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c567c8fc5ee98ba79466e95d1ba03183
https://doi.org/10.1016/j.heliyon.2019.e01292
https://doi.org/10.1016/j.heliyon.2019.e01292
Autor:
Tetsuya Shimizugawa, Shizuya Yamashita, Mitsuru Shimamura, Ryutaro Komuro, Takafumi Kohama, Tatsuo Ishida, Kazuaki Kotani, Keita Kono, Hiroaki Yasumo, Ken-ichi Hirata, Naohiko Sakai, Yosuke Ando, Iichiro Shimomura, Mitsuyo Okazaki, Hidehiko Furukawa, Kazunori Fujimoto, Ryuta Koishi, Morihiro Matsuda
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 27:366-372
Objectives— A low level of high-density lipoprotein (HDL) in plasma has been recognized as an aspect of metabolic syndrome and as a crucial risk factor of cardiovascular events. However, the physiological regulation of plasma HDL levels has not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46e3b8852f8a0702dfb168bb1645d66
https://doi.org/10.1161/01.atv.0000252827.51626.89
https://doi.org/10.1161/01.atv.0000252827.51626.89
Publikováno v:
Journal of Receptors and Signal Transduction. 27:323-334
Dresden G protein-coupled receptor (D-GPCR) is one of orphan G protein-coupled receptors (GPCR). Here we report the identification of the ligands and the characterization of D-GPCR. We investigated over 5000 compounds to evoke the response mediated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52630e7e990a93aaa64d652ba8c4fde7
https://doi.org/10.1080/10799890701534180
https://doi.org/10.1080/10799890701534180