Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome‐Wide Association and Mendelian Randomization Study

Autor: Kosuke Inoue, Tatsuhiko Naito, Ryosuke Fuji, Kyuto Sonehara, Kenichi Yamamoto, Ryuta Baba, Takaya Kodama, Yu Otagaki, Akira Okada, Kiyotaka Itcho, Kazuhiro Kobuke, Haruya Ohno, Takayuki Morisaki, Noboru Hattori, Atsushi Goto, Tetsuo Nishikawa, Kenji Oki, Yukinori Okada

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 15 (2024)

Background Observational studies have reported associations between primary aldosteronism (PA) and cardiovascular outcomes, including coronary artery diseases (CAD), congestive heart failure (CHF), and stroke. However, establishing causality remains

Externí odkaz: https://doaj.org/article/d8c02857d41640e2a219bc6762859cf6

Angiotensin-converting enzyme 2 expression is not induced by the renin–angiotensin system in the lung

Autor: Ryuta Baba, Kenji Oki, Kiyotaka Itcho, Kazuhiro Kobuke, Gaku Nagano, Haruya Ohno, Masayasu Yoneda, Noboru Hattori

Publikováno v: ERJ Open Research, Vol 6, Iss 4 (2020)

Externí odkaz: https://doaj.org/article/4e7b1311b3054127acec34d5a33d9ef3

Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production

Autor: Elise P. Gomez-Sanchez, Kiyotaka Itcho, Masayasu Yoneda, Kazuhiro Kobuke, Haruya Ohno, Celso E. Gomez-Sanchez, Noboru Hattori, Ryuta Baba, Gaku Nagano, Kenji Oki, Yoko Yoshii

Publikováno v: Hypertension. 75:492-499

The endoplasmic reticulum (ER) plays a pivotal role in syntheses of proteins and steroid hormones and regulation of intracellular Ca 2+ level. We aimed to investigate ER-associated genes in aldosterone-producing adenomas (APAs) and clarify their effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e17020cb47cd5e5e5c6a9c7c83fcd2
https://doi.org/10.1161/hypertensionaha.119.14062

ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation

Autor: Elise P. Gomez-Sanchez, Masayasu Yoneda, Kazuhiro Kobuke, Kiyotaka Itcho, Kenji Oki, Koji Arihiro, Yoko Yoshii, Celso E. Gomez-Sanchez, Noboru Hattori, Takaya Kodama, Haruya Ohno, Ryuta Baba, Gaku Nagano

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 10981, p 10981 (2021)

The molecular mechanisms by which ATP1A1 mutation-mediated cell proliferation or tumorigenesis in aldosterone-producing adenomas (APAs) have not been elucidated. First, we investigated whether the APA-associated ATP1A1 L104R mutation stimulated cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba4cddab63b226e06ac973c09b88168
http://europepmc.org/articles/PMC8537586

Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels

Autor: Haruya Ohno, Ryuta Baba, Kiyotaka Itcho, Kazuhiro Kobuke, Kenji Oki, Noboru Hattori, Masayasu Yoneda, Hirofumi Okubo

Publikováno v: Steroids. 140:179-184

Objective Elevated midnight cortisol levels induced by non-suppressed ACTH levels may lead to false-positive results for hypercortisolism in patients with adrenal incidentaloma. We investigated whether plasma ACTH-associated high midnight serum corti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d5aa54ab95b2f8933194b85855b12f
https://doi.org/10.1016/j.steroids.2018.10.011