Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ryusei Chimori"'
Autor:
Ryoko Takasawa, Akane Jona, Manami Inoue, Miku Azuma, Haruka Akahane, Yuto Ueno, Yuki Nakagawa, Ryusei Chimori, Yasunari Mano, Yuki Murata, Shuji Yasuike, Toshiyuki Kaji
Publikováno v:
The Journal of toxicological sciences. 47(12)
Organobismuth compounds, i.e., organic-inorganic hybrid molecules composed of an organic structure and bismuth metal, have been reported to induce cytotoxicity in cancer cells; however, the target proteins associated with this cytotoxicity have not b
Autor:
Miku Azuma, Haruka Akahane, Manami Inoue, Masataka Kitajima, Sei-ichi Tanuma, Atsushi Yoshimori, Shunsuke Natani, Hiromi Uchiro, Ryoko Takasawa, Ryusei Chimori, Yasunari Mano, Aya Nishida
Publikováno v:
Bioorganicmedicinal chemistry letters. 40
Glyoxalase I (GLO I) is a known therapeutic target in cancer. Even though TLSC702, a GLO I inhibitor that we discovered, induces apoptosis in tumor cells, exceptionally higher doses are required compared with those needed to inhibit GLO I activity in