Výsledky vyhledávání - "Ryunosuke, Nakashima"

Akademický článek

Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases

Autor: Ryunosuke Nakashima, Hirofumi Nohara, Noriki Takahashi, Aoi Nasu, Megumi Hayashi, Tomoki Kishimoto, Shunsuke Kamei, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Keiko Ueno-Shuto, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto

Publikováno v: Journal of Pharmacological Sciences, Vol 149, Iss 2, Pp 37-45 (2022)

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world, and has no radical treatment. Inhibition of amiloride-sensitive epithelial sodium ion channel (ENaC) has now been considered as a potential therapeutic t

Externí odkaz: https://doaj.org/article/a3fdda52c3ac4d2197ce82bec8cd299c

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Akademický článek

T3 Intratracheal Therapy Alleviates Pulmonary Pathology in an Elastase-Induced Emphysema-Dominant COPD Mouse Model

Autor: Noriki Takahashi, Ryunosuke Nakashima, Aoi Nasu, Megumi Hayashi, Haruka Fujikawa, Taisei Kawakami, Yuka Eto, Tomoki Kishimoto, Ayami Fukuyama, Choyo Ogasawara, Keisuke Kawano, Yukio Fujiwara, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto

Publikováno v: Antioxidants, Vol 13, Iss 1, p 30 (2023)

Chronic obstructive pulmonary disease (COPD) is a complex pulmonary condition characterized by bronchitis, emphysema, and mucus stasis. Due to the variability in symptoms among patients, traditional approaches to treating COPD as a singular disease a

Externí odkaz: https://doaj.org/article/429d4f2c1e6347a3864b86644b249303

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Akademický článek

Auto-measure emphysematous parameters and pathophysiological gene expression profiles in experimental mouse models of acute and chronic obstructive pulmonary diseases

Autor: Ryunosuke Nakashima, Shunsuke Kamei, Hirofumi Nohara, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Noriki Takahashi, Mary Ann Suico, Toru Takeo, Naomi Nakagata, Hirofumi Kai, Tsuyoshi Shuto

Publikováno v: Journal of Pharmacological Sciences, Vol 140, Iss 2, Pp 113-119 (2019)

Pulmonary emphysema, inflammation and senescence-like phenotype are pathophysiological characteristics of chronic obstructive pulmonary disease (COPD). Recently, a murine model of COPD has been established by inducing airway-specific overexpression o

Externí odkaz: https://doaj.org/article/9dba2af5bc884f9f9a2c4e0d58be15c4

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Akademický článek

Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells

Autor: Shunsuke Kamei, Haruka Fujikawa, Hirofumi Nohara, Keiko Ueno-Shuto, Kasumi Maruta, Ryunosuke Nakashima, Taisei Kawakami, Chizuru Matsumoto, Yuki Sakaguchi, Tomomi Ono, Mary Ann Suico, Richard C. Boucher, Dieter C. Gruenert, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Hirofumi Kai, Tsuyoshi Shuto

Publikováno v: EBioMedicine, Vol 27, Iss C, Pp 304-316 (2018)

Airway mucus hyperproduction and fluid imbalance are important hallmarks of cystic fibrosis (CF), the most common life-shortening genetic disorder in Caucasians. Dysregulated expression and/or function of airway ion transporters, including cystic fib

Externí odkaz: https://doaj.org/article/19a6570ae092400f9570190db666d79f

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Akademický článek

Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor against Pathophysiological Decline of Lung Function

Publikováno v: Antioxidants, Vol 9, Iss 5, p 387 (2020)

The oxidant/antioxidant imbalance plays a pivotal role in the lung. Uric acid (UA), an endogenous antioxidant, is highly present in lung tissue, however, its impact on lung function under pathophysiological conditions remains unknown. In this work, p

Externí odkaz: https://doaj.org/article/a1b150bf3848422eb2fba666b5aeeeac

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Azithromycin Inhibits Constitutive Airway Epithelial Sodium Channel Activation in Vitro and Modulates Downstream Pathogenesis in Vivo

Autor: Tsuyoshi Shuto, Hirofumi Nohara, Toru Takeo, Hirofumi Kai, Yuka Eto, Taise Kawakami, Mary Ann Suico, Shunsuke Kamei, Aoi Nasu, Ryunosuke Nakashima, Haruka Fujikawa, Naomi Nakagata, Keiko Ueno-Shuto

Publikováno v: Biological and Pharmaceutical Bulletin. 43:725-730

Epithelial sodium channel (ENaC) is an amiloride-sensitive sodium ion channel that is expressed in epithelial tissues. ENaC overexpression and/or hyperactivation in airway epithelial cells cause sodium over-absorption and dysregulated ciliary movemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdd394a4c75370e657e6af678fdccbb8
https://doi.org/10.1248/bpb.b19-01091

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Curcumin Down-Regulates Toll-Like Receptor-2 Gene Expression and Function in Human Cystic Fibrosis Bronchial Epithelial Cells

Autor: Haruka Fujikawa, Yuko Ohira, Niraj Chaudhary, Keiko Ueno-Shuto, Noriki Takahashi, Mary Ann Suico, Hirofumi Kai, Aoi Nasu, Ryunosuke Nakashima, Kenji Watanabe, Tomomi Ono, Tsuyoshi Shuto

Publikováno v: Biological and Pharmaceutical Bulletin. 42:489-495

Cystic fibrosis (CF), the most common lethal inherited disorder caused by mutation in the gene encoding the CF transmembrane regulator (CFTR), is characterized by chronic inflammation that ultimately leads to death from respiratory failure. In CF pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3891184b96e7fbd5abbe0c1c15fb13
https://doi.org/10.1248/bpb.b18-00928

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Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor against Pathophysiological Decline of Lung Function

Publikováno v: Antioxidants, Vol 9, Iss 387, p 387 (2020)
Antioxidants
Volume 9
Issue 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6e0928baa8f17fef652c8f4c65591c
https://www.mdpi.com/2076-3921/9/5/387

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