Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ryuki MIYAUCHI"'
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240673 (2020)
Some monoclonal antibodies undergo liquid-liquid phase separation owing to self-attractive associations involving electrostatic and other soft interactions, thereby rendering monoclonal antibodies unsuitable as therapeutics. To mitigate the phase sep
Externí odkaz:
https://doaj.org/article/aa611d665e184356865ac1643d7f6f33
Autor:
Sangwook Kim, Ryuki Miyauchi, Yukio Sato, Hyunwook Nam, Ichiro Fujii, Shintaro Ueno, Yoshihiro Kuroiwa, Satoshi Wada
Publikováno v:
Advanced Materials. 35
Piezoelectric materials play a key role in applications, while there are physically open questions. The physical origin of piezoelectricity is understood as the sum of contributions from intrinsic effects on lattice dynamics and those from extrinsic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834af6f211a0dbc611409a71358505f5
https://doi.org/10.1002/adma.202208717
https://doi.org/10.1002/adma.202208717
Emergence of new SARS-CoV-2 variants has raised concerns at the effectiveness of vaccines and antibody therapeutics developed against the unmutated wild-type virus. We examined the effect of 12 most commonly occurring mutations in the receptor bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b699d222a5af19b36b3969086546e94c
https://doi.org/10.1101/2021.05.23.445348
https://doi.org/10.1101/2021.05.23.445348
Publikováno v:
The Journal of Biological Chemistry
Emergence of new severe acute respiratory syndrome coronavirus 2 variants has raised concerns related to the effectiveness of vaccines and antibody therapeutics developed against the unmutated wildtype virus. Here, we examined the effect of the 12 mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292be13963a240f9c5855f10f8393482
https://doi.org/10.1016/j.jbc.2021.101208
https://doi.org/10.1016/j.jbc.2021.101208
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0240673 (2020)
PLoS ONE, Vol 15, Iss 10, p e0240673 (2020)
Some monoclonal antibodies undergo liquid-liquid phase separation owing to self-attractive associations involving electrostatic and other soft interactions, thereby rendering monoclonal antibodies unsuitable as therapeutics. To mitigate the phase sep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8e9ea9e4b78e362fe707de6f58341b
https://doi.org/10.1371/journal.pone.0240673
https://doi.org/10.1371/journal.pone.0240673
Autor:
Hiroyuki Chaya, Takahiro Nagayama, Makoto Yoshida, Yukiko Sekiguchi, Jun Hasegawa, Nakamura Kensuke, Takeshi Shiiki, Masako Soma, Shohei Oishi, Takahiro Yamaguchi, Takeshi Honda, Yutaka Mori, Ryuki Miyauchi, Iwamoto Mitsuhiro
Publikováno v:
Bioconjugate chemistry. 29(8)
Atrial natriuretic peptide (ANP) exerts beneficial pharmacological effects in the treatment of various cardiovascular disorders, such as acute congestive heart failure (ADHF). However, the clinical use of ANP is limited to the continuous intravenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ded42d5421c78b4903f17c00f6d28af
https://pubmed.ncbi.nlm.nih.gov/30107743
https://pubmed.ncbi.nlm.nih.gov/30107743
Autor:
Kentaro Nagatomo, Suzuki Chikako, Hidetoshi Ishihara, Yuki Nagano, Gabriele Matschiner, Ryuki Miyauchi, Shinji Yamaguchi, Futoshi Nara, Kazuaki Okuno, Tohru Takahashi, Yusuke Masuda, Tomohiro Nishizawa, Takahide Aburatani, Eiko Suzuki, Naotoshi Yamamura, Ryuji Hashimoto
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 365(2)
Since it was recently reported that an antibody for proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces the risk of cardiovascular events in a clinical context, PCSK9 inhibition is thought to be an attractive therapy for dyslipidemia. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22500a7a074f42e5b631d6fcde54b62
https://pubmed.ncbi.nlm.nih.gov/29463608
https://pubmed.ncbi.nlm.nih.gov/29463608
Publikováno v:
physica status solidi (RRL) – Rapid Research Letters. 14:1900488
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f74fcf4ddc8062c417c62946543940e
https://doi.org/10.1002/pssr.201900488
https://doi.org/10.1002/pssr.201900488
Publikováno v:
AMB Express
A fungus, Thelonectria discophora SANK 18292 (JCM 30947), produces nectrisine that has a nitrogen-containing heterocyclic 5-membered ring acting as a glycosidase inhibitor. Our previous study showed the possibility that 4-amino-4-deoxyarabinitol was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfdab3194779e1c8526b7817d2d496b7
https://doi.org/10.1186/s13568-016-0176-1
https://doi.org/10.1186/s13568-016-0176-1
Additional file 1: Fig. S1. Conversion of 4-amino-4-deoxyarabinitol to nectrisine with His-tagged NecC expressed by recombinant E. coli. a, b, and c, Absorbance chromatograms; d, e, and f, the extracted MS chromatograms for m/z 297.1 which is the [M+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fd00096443e5186aabf450322e1ec0