Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Ryuji Uchida"'
Autor:
Hiroyuki Yamazaki, Satoshi Ohte, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Delfly B. Abdjul, Wilmar Maarisit, Magie M. Kapojos, Michio Namikoshi, Takenobu Katagiri, Hiroshi Tomoda, Ryuji Uchida
Publikováno v:
Marine Drugs, Vol 18, Iss 12, p 606 (2020)
Fibrodysplasia ossificans progressiva (FOP) is a rare congenital disorder with heterotopic ossification (HO) in soft tissues. The abnormal activation of bone morphogenetic protein (BMP) signaling by a mutant activin receptor-like kinase-2 (ALK2) lead
Externí odkaz:
https://doaj.org/article/f9e7be7129464f43aa42b3f4c9b8323a
Autor:
Kanji Hosoda, Nobuhiro Koyama, Hiroshi Hamamoto, Akiho Yagi, Ryuji Uchida, Akihiko Kanamoto, Hiroshi Tomoda
Publikováno v:
Molecules, Vol 25, Iss 21, p 4971 (2020)
Among four mycobacteria, Mycobacterium avium, M. intracellulare, M. bovis BCG and Mycobacteroides (My.) abscessus, we established a silkworm infection assay with My. abscessus. When silkworms (fifth-instar larvae, n = 5) were infected through the hem
Externí odkaz:
https://doaj.org/article/83a2f6e801234efd8da055e12df08238
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 4, Iss 2, Pp 141-145 (2014)
2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibit
Externí odkaz:
https://doaj.org/article/2945869c097d4713963016f1072d7d67
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 3, Iss 3, Pp 163-166 (2013)
Monapinones A (1) to E (5), half parts of dinapinones, were produced by fermentation of Talaromyces pinophilus FKI-3864 in seawater-containing medium and have a common dihydronaphthopyranone skeleton with a different long alkyl chain. The relative st
Externí odkaz:
https://doaj.org/article/82e92485527b4759b1806066b46dae8c
Autor:
Takashi Fukuda, Ryuji Uchida, Hiroyo Inoue, Satoshi Ohte, Hiroyuki Yamazaki, Daisuke Matsuda, Takenobu Katagiri, Hiroshi Tomoda
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 2, Iss 1, Pp 23-27 (2012)
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant congenital disorder characterized by progressive heterotopic ossification in muscle tissues. A constitutively activated mutation of a bone morphogenetic protein (BMP) receptor,
Externí odkaz:
https://doaj.org/article/6771e318916f4342a1feb7cdc783e048
Autor:
Ayumu Demachi, Satoshi Ohte, Ryuji Uchida, Kazuo Shin-ya, Taichi Ohshiro, Hiroshi Tomoda, Haruo Ikeda
Publikováno v:
The Journal of Antibiotics. 75:305-311
A key intermediate in scopranone biosynthesis, prescopranone, accumulated in the mycelium of Streptomyces avermitilis SUKA carrying the biosynthetic gene cluster for scopranone lacking the sprT encoding the monooxygenase. The structure of prescoprano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206298c5bbe4aa2cd98a495e7a00a201
https://doi.org/10.1038/s41429-022-00521-x
https://doi.org/10.1038/s41429-022-00521-x
Autor:
Miyuki, Konya, Shiho, Arima, Daiki, Lee, Masaki, Ohtawa, Kenta, Shimoyama, Takashi, Fukuda, Ryuji, Uchida, Hiroshi, Tomoda, Noriyuki, Yamaotsu, Nobutada, Tanaka, Tohru, Nagamitsu
Publikováno v:
Chemical and Pharmaceutical Bulletin. 70:261-268
Habiterpenol is a G2 checkpoint inhibitor isolated from the culture broth of Phytohabitans sp. 3787_5. Here, we report the synthesis of new habiterpenol analogs through the total synthesis process of habiterpenol and evaluating the analogs for G2 che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a28e698093094a5a6fa95767d9bd6f4
https://doi.org/10.1248/cpb.c21-00993
https://doi.org/10.1248/cpb.c21-00993
Publikováno v:
The Journal of antibiotics.
Four new piericidin rhamnosides (2, 4-6) together with three known piericidins (1, 3, 7) were isolated from the culture broth of the unidentified actinomycete strain TMPU-A0287 as potentiators of antifungal amphotericin B (AmB) activity. The structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce7355bd41af06171194f0251e3f8639
https://pubmed.ncbi.nlm.nih.gov/36460732
https://pubmed.ncbi.nlm.nih.gov/36460732
Autor:
Ryuji Uchida, Akiho Yagi, Takeshi Terahara, Hiroyuki Yamazaki, Hiroshi Hamamoto, Chiaki Imada, Taehui Yang, Hiroshi Tomoda
Publikováno v:
Drug Discoveries & Therapeutics. 14:287-295
In vivo-mimic silkworm infection models with Mycobacterium avium and Mycobacterium intracellulare were newly established to evaluate the therapeutic effects of anti-M. avium complex (MAC) antibiotics. Silkworms raised at 37°C died within 72 hours of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de9471de98902e06d862927ea70048f3
https://doi.org/10.5582/ddt.2020.03099
https://doi.org/10.5582/ddt.2020.03099
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:903-906
Bioassay screening using Indonesian plants, such as traditional foods (vegetables, spices, and tea) and folk medicinal herbs, identified eight protein tyrosine phosphatase (PTP) 1B inhibitory and two antibacterial plants. The leaves of Syzygium polya
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e176df1b9b51c2474589e8fb7f4a4c
https://doi.org/10.1248/cpb.c20-00457
https://doi.org/10.1248/cpb.c20-00457