Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ryuji Tanimura"'
Autor:
Mikiya Satoh, Hajime Saburi, Tomoyuki Tanaka, Yoshinori Matsuura, Hisashi Naitow, Rieko Shimozono, Naoyoshi Yamamoto, Hideki Inoue, Noriko Nakamura, Yoshitaka Yoshizawa, Takumi Aoki, Ryuji Tanimura, Naoki Kunishima
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 557-570 (2015)
Keap1 protein acts as a cellular sensor for oxidative stresses and regulates the transcription level of antioxidant genes through the ubiquitination of a corresponding transcription factor, Nrf2. A small molecule capable of binding to the Nrf2 intera
Externí odkaz:
https://doaj.org/article/5c6177d8769e4965b1baa645f8d1c73f
Autor:
Kenta Maeda, Sayaka Ohrui, Akihisa Tokuda, Yasuyuki Nagumo, Naoshi Yamamoto, Ryuji Tanimura, Tsuyoshi Saitoh, Noriki Kutsumura, Hiroshi Nagase
Publikováno v:
Organic Letters. 25:3407-3411
Autor:
Keita Iio, Kao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Naoshi Yamamoto, Noriki Kutsumura, Katsuhiko Takeuchi, Yukiko Ishikawa, Hikari Yamamoto, Akihisa Tokuda, Tetsu Sato, Yasuo Uchida, Asuka Inoue, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase, Tsuyoshi Saitoh
Publikováno v:
Journal of Medicinal Chemistry. 66:5453-5464
Autor:
Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
Publikováno v:
Bioorganicmedicinal chemistry letters. 60
A novel series of 1-amino-tetralin derivatives were designed and synthesized based on the putative binding mode of the naphthalene-type orexin receptor agonist 5 and their agonist activities against orexin receptors were evaluated. The introduction o
Autor:
Yukiko Ishikawa, Yoko Irukayama-Tomobe, Tsubasa Hino, Naoshi Yamamoto, Hiroshi Nagase, Yasuyuki Nagumo, Masashi Yanagisawa, Noriki Kutsumura, Tsuyoshi Saitoh, Ryuji Tanimura
Publikováno v:
Bioorganicmedicinal chemistry letters. 59
A novel series of naphthalene derivatives were designed and synthesized based on the strategy focusing on the restriction of the flexible bond rotation of OX2R selective agonist YNT-185 (1) and their agonist activities against orexin receptors were e
Autor:
Noriki Kutsumura, Tsuyoshi Saitoh, Jumpei Horiuchi, Yukiko Ishikawa, Emi Hasegawa, Yasuyuki Nagumo, Masashi Yanagisawa, Takeshi Sakurai, Ryuji Tanimura, Hiroaki Gouda, Naoshi Yamamoto, Yasuhiro Ogawa, Akihisa Tokuda, Tetsu Sato, Yoko Irukayama-Tomobe, Mao Amezawa, Hiroshi Nagase, Ryuichiro Oshita, Yasuo Uchida
Structurally diverse small compounds are utilized to obtain hit compounds that have suitable pharmacophores in appropriate three-dimensional conformations for the target drug receptors. We have focused on the 1,3,5-trioxazatriquinane skeleton, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4079393b5fe25c5fc1566ec1c12834a
https://doi.org/10.33774/chemrxiv-2021-08md1
https://doi.org/10.33774/chemrxiv-2021-08md1
Autor:
Tsuyoshi Saitoh, Mao Amezawa, Jumpei Horiuchi, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Ryuichiro Ohshita, Akihisa Tokuda, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Emi Hasegawa, Takeshi Sakurai, Yasuo Uchida, Tetsu Sato, Hiroaki Gouda, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
Structurally diverse small compounds are utilized to obtain hit compounds that have suitable pharmacophores in appropriate three-dimensional conformations for the target drug receptors. We have focused on the 1,3,5-trioxazatriquinane skeleton, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0571529b5d14b8ad54e10a712a84a9
https://doi.org/10.26434/chemrxiv-2021-08md1
https://doi.org/10.26434/chemrxiv-2021-08md1
Autor:
Koki Katoh, Naoshi Yamamoto, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Ryuji Tanimura, Tsuyoshi Saitoh, Yasuyuki Nagumo, Noriki Kutsumura, Masashi Yanagisawa, Hiroshi Nagase
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 59:128527
To investigate the contribution of hydrogen bonding between the 14-hydroxy group and the 6-amide chain on the binding affinity of nalfurafine toward KOR and OX
Autor:
Koki Katoh, Noriki Kutsumura, Naoshi Yamamoto, Yasuyuki Nagumo, Tsuyoshi Saitoh, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 59:128550
The five-membered D-ring nalfurafine (d-nor-nalfurafine) derivatives with a 16-sulfonamide group were synthesized. Conversion of the 16-cyclopropylmethyl group to the 16-benzenesulfonamide group in the d-nor-nalfurafine derivatives drastically improv
Autor:
Yuji Sugawara, Riichiro Tsuji, Ryuji Tanimura, Atsushi Inoue, Hideaki Inada, Koji Kawai, Chizuka Sakai, Eriko Higashi, Mitsuhiro Konno, Shinya Suzuki, Rieko Shimozono, Tomofumi Ohyama
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 65:1085-1088
κ-Opioid receptor agonists with high selectivity over the μ-opioid receptor and peripheral selectivity are attractive targets in the development of drugs for pain. We have previously attempted to create novel analgesics with peripheral selective κ