Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ryuji Owada"'
Autor:
Takeru Kashiwada, Ryotaro Takano, Fumihiko Ando, Shoko Kuroda, Yoshishige Miyabe, Ryuji Owada, Akihiko Miyanaga, Tomoko Asatsuma-Okumura, Masaaki Hashiguchi, Yoshikazu Kanazawa, Hiroshi Yoshida, Masahiro Seike, Akihiko Gemma, Yoshiko Iwai
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Immune checkpoint inhibitors (ICIs) can induce immune-related adverse events (irAEs). Liquid biomarkers to predict irAE occurrence are urgently needed. We previously developed an ELISA system to specifically detect soluble PD-L1 (sPD-L1)
Externí odkaz:
https://doaj.org/article/9f25c0d48b8e40b28822e0ee50aa0364
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0296750 (2024)
Whether fibril formation increases or decreases cytotoxicity remains unclear. Aggregation of human islet amyloid polypeptide (hIAPP), a pivotal regulator of glucose homeostasis, impairs the function and viability of pancreatic β cells. Evidence sugg
Externí odkaz:
https://doaj.org/article/8159ac3aaa224a3fa4e372cacee00dba
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Repeat-associated non-AUG translation (RAN translation) is observed in transcripts that are causative for polyglutamine (polyQ) diseases and generates proteins with mono amino acid tracts such as polyalanine (polyA), polyleucine (polyL) and
Externí odkaz:
https://doaj.org/article/ce0e1912bc514b9b93b69a53b8de9328
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Repeat-associated non-AUG (RAN) translation of mRNAs/transcripts responsible for polyglutamine (polyQ) diseases may generate peptides containing different mono amino acid tracts such as polyserine (polyS) and polyleucine (polyL). The propaga
Externí odkaz:
https://doaj.org/article/70ca2cb6191449d3b736281cac076c5a
Autor:
Yutaro Iizuka, Ryuji Owada, Takayasu Kawasaki, Fumio Hayashi, Masashi Sonoyama, Kazuhiro Nakamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract In polyalanine (PA) diseases, the disease-causing transcription factors contain an expansion of alanine repeats. While aggregated proteins that are responsible for the pathogenesis of neurodegenerative disorders show cell-to-cell propagation
Externí odkaz:
https://doaj.org/article/23d0c4209bfd4d6888037625305ffe9f
Publikováno v:
Heliyon, Vol 6, Iss 9, Pp e04851- (2020)
Expanded polyglutamine-containing proteins in neurons intrinsically contributes to neuronal dysfunctions and neuronal cell death in polyglutamine (polyQ) diseases. In addition, an expanded polyQ-containing protein in microglia also leads to apoptosis
Externí odkaz:
https://doaj.org/article/77e95cca02e842dfa5cf665721c65faf
Publikováno v:
Heliyon, Vol 6, Iss 9, Pp e04851-(2020)
Heliyon
Heliyon
Expanded polyglutamine-containing proteins in neurons intrinsically contributes to neuronal dysfunctions and neuronal cell death in polyglutamine (polyQ) diseases. In addition, an expanded polyQ-containing protein in microglia also leads to apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eddba359e2c7fd028c520ee954de947
http://www.sciencedirect.com/science/article/pii/S2405844020316947
http://www.sciencedirect.com/science/article/pii/S2405844020316947
Autor:
Takayuki Imai, Takayasu Kawasaki, Koichi Tsukiyama, Ryuji Owada, Shin-ichi Izumi, Kazuhiro Nakamura, Hiroyasu Kanetaka, Miho Mohara
Publikováno v:
Neuroscience Letters. 685:42-49
Proteins containing an expanded polyglutamine tract tend to aggregate, leading to the neuronal damage observed in polyglutamine diseases. We recently reported that free electron laser (FEL) irradiation markedly dissociates naked polyglutamine aggrega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942d6cca89cdc8d202d8e3e8d3ff632c
https://doi.org/10.1016/j.neulet.2018.07.031
https://doi.org/10.1016/j.neulet.2018.07.031