Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ryuji Hashimoto"'
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244656 (2020)
Matrix metalloproteinases (MMPs) contribute to many physiological and pathological phenomena via the proteolysis of extracellular matrix components. Specific blocking of the active site of each MMP sheds light on its particular role. However, it rema
Externí odkaz:
https://doaj.org/article/76b2649281cb4e56b32db920c744ef82
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Single domain antibodies (sdAbs), made of natural single variable regions of camelid or cartilaginous fish antibodies, or unpaired variable regions of mouse or human IgGs, are some of the more promising biologic modalities. However, such con
Externí odkaz:
https://doaj.org/article/ad22077988eb44aeab1bd0872d14680f
Autor:
Takuya Sato, Ryuji Hashimoto, Yoshitomo Tanaka, Kenichi Suzuki, Yasushi Enokido, Kyung-Ku Choi, Takao Suzuki
Publikováno v:
AIP Advances, Vol 8, Iss 5, Pp 056213-056213-6 (2018)
The magnetic properties of Nd-Fe-B thin films with the three different compositions (#1: Nd12.6Fe81.5B5.9, #2: Nd14.6Fe78.1B7.4 and #3: Nd22.6Fe66.2B11.2) are discussed. With increasing Nd content, the c-axis orientation along the film normal is enha
Externí odkaz:
https://doaj.org/article/222b16efb28b421fae7f345f2e892a47
Autor:
Tomoyasu Taniyama, Ryuji Hashimoto, Yasushi Enokido, Sato Takuya, Yuji Umeda, Kenichi Suzuki, Yoshitomo Tanaka
Publikováno v:
Journal of the Japan Society of Powder and Powder Metallurgy. 65:265-268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9bd6f1251bec7ed5a0f0532d68e996a
https://doi.org/10.2497/jjspm.65.265
https://doi.org/10.2497/jjspm.65.265
Publikováno v:
Lipids. 51:1207-1216
Compounds that modulate the activity of sphingosine 1-phosphate (S1P)-metabolizing enzymes are expected to be potential therapeutic agents for various diseases. Investigation of their potencies requires not only cell-free but also cell-based assays i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d2bba54862572d4a63b62760ba7b09
https://doi.org/10.1007/s11745-016-4187-0
https://doi.org/10.1007/s11745-016-4187-0
Autor:
Mamoru Ohtoyo, Takaichi Shimozato, Masakazu Tamura, Katsunobu Hagihara, Jun Watanabe, Jun Chiba, Nobuo Machinaga, Yoshimasa Kobayashi, Yasuo Kita, Miyuki Nagasaki, Koji Abe, Ryuji Hashimoto, Ryotaku Inoue, Fumihito Muro, Hiroshi Yuita
Publikováno v:
Cell Chemical Biology. 23:555-560
Summary Caramel color is widely used in the food industry, and its many variations are generally considered to be safe. It has been known for a long time that THI (2-acetyl-4-(tetrahydroxybutyl)imidazole), a component of caramel color III, causes lym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112b01c3b4daf948cd909a82d6c77490
https://doi.org/10.1016/j.chembiol.2016.04.007
https://doi.org/10.1016/j.chembiol.2016.04.007
Autor:
Kentaro Nagatomo, Suzuki Chikako, Hidetoshi Ishihara, Yuki Nagano, Gabriele Matschiner, Ryuki Miyauchi, Shinji Yamaguchi, Futoshi Nara, Kazuaki Okuno, Tohru Takahashi, Yusuke Masuda, Tomohiro Nishizawa, Takahide Aburatani, Eiko Suzuki, Naotoshi Yamamura, Ryuji Hashimoto
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 365(2)
Since it was recently reported that an antibody for proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces the risk of cardiovascular events in a clinical context, PCSK9 inhibition is thought to be an attractive therapy for dyslipidemia. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22500a7a074f42e5b631d6fcde54b62
https://pubmed.ncbi.nlm.nih.gov/29463608
https://pubmed.ncbi.nlm.nih.gov/29463608
Publikováno v:
Molecular and Cellular Biochemistry. 400:125-133
Caramel food colorant 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) causes lymphopenia in animals through sphingosine 1-phosphate lyase (SPL) inhibition. However, this mechanism of action is partly still controversial because THI did not inhibit SPL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281e32c573239e7572c1b6183e4a3f53
https://doi.org/10.1007/s11010-014-2268-z
https://doi.org/10.1007/s11010-014-2268-z
Autor:
Hiroshi Yokota, Ryuji Hashimoto, Ryo Hatano, Tatsuya Kawaguchi, Kyoji Yamaguchi, Katsuhiko Nawa
Publikováno v:
Cell Biology International. 36:39-45
We investigated PPF (proplatelet formation) in the human megakaryocytic cell line UT-7/TPO in vitro and signal transduction pathways responsible for PPF. The megakaryocytic cell lines are useful for studying megakaryocyte biology, although PPF is ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7851457d4a923cd9a6cd30f597274b1
https://doi.org/10.1042/cbi20110383
https://doi.org/10.1042/cbi20110383
Publikováno v:
Cell Biology International. 34:943-949
We have demonstrated that a unique megakaryocytic cell line UT-7/TPO could respond to one of the primary platelet signals through GP (glycoprotein) VI and a secondary signal of the AA (arachidonic acid) cascade. Unlike other megakaryocytic cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41886e57b96f32e086bae7be6944c3f
https://doi.org/10.1042/cbi20090491
https://doi.org/10.1042/cbi20090491