Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Ryuji, Inoue"'
Autor:
Masayuki X. Mori, Ryo Okada, Reiko Sakaguchi, Hideharu Hase, Yuko Imai, Onur K. Polat, Satoru G. Itoh, Hisashi Okumura, Yasuo Mori, Yasushi Okamura, Ryuji Inoue
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2) regulates the activities of numerous membrane proteins, including diacylglycerol(DAG)-activated TRPC3/6/7 channels. Although PIP2 binding is known to support DAG-activated TRP channel
Externí odkaz:
https://doaj.org/article/f7c90b4d91374713a6e8dee08565a3d1
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11798 (2023)
The transient receptor potential melastatin 4 (TRPM4) channel is a non-selective cation channel that activates in response to increased intracellular Ca2+ levels but does not allow Ca2+ to pass through directly. It plays a crucial role in regulating
Externí odkaz:
https://doaj.org/article/e93cbaf8a6d848a3894cb55ed43bdf46
Autor:
Seiji Sakamoto, Kei Yamaura, Tomohiro Numata, Fumio Harada, Kazuma Amaike, Ryuji Inoue, Shigeki Kiyonaka, Itaru Hamachi
Publikováno v:
ACS Central Science, Vol 5, Iss 9, Pp 1541-1553 (2019)
Externí odkaz:
https://doaj.org/article/6ce21df253e94d0ea84bc3a0729d5e7b
Autor:
Lin Hai Kurahara, Keizo Hiraishi, Yaopeng Hu, Kaori Koga, Miki Onitsuka, Mayumi Doi, Kunihiko Aoyagi, Hidetoshi Takedatsu, Daibo Kojima, Yoshitaka Fujihara, Yuwen Jian, Ryuji Inoue
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 299-318 (2018)
The transient receptor potential ankyrin 1 (TRPA1) channel is highly expressed in the intestinal lamina propria, but its contribution to gut physiology/pathophysiology is unclear. Here, we evaluated the function of myofibroblast TRPA1 channels in int
Externí odkaz:
https://doaj.org/article/1438c7fd8366470181e1e4170290e1e2
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8513 (2021)
In the heart, TRPM4 is most abundantly distributed in the conduction system. Previously, a single mutation, ‘E7K’, was identified in its distal N-terminus to cause conduction disorder because of enhanced cell-surface expression. It remains, howev
Externí odkaz:
https://doaj.org/article/7d96f5d2ef944177862820167a3b3595
Autor:
Yaopeng Hu, Qin Li, Lin-Hai Kurahara, Narumi Shioi, Keizo Hiraishi, Takayuki Fujita, Xin Zhu, Ryuji Inoue
Publikováno v:
Cells, Vol 10, Iss 5, p 983 (2021)
A Ca2+-activated monovalent cation-selective TRPM4 channel is abundantly expressed in the heart. Recently, a single gain-of-function mutation identified in the distal N-terminus of the human TRPM4 channel (Glu5 to Lys5; E7K) was found to be arrhythmo
Externí odkaz:
https://doaj.org/article/75beb3bccd61441790ac3853e474498e
Autor:
Keizo, Hiraishi, Lin Hai, Kurahara, Kaori, Ishikawa, Tetsuhiko, Go, Naoya, Yokota, Yaopeng, Hu, Takayuki, Fujita, Ryuji, Inoue, Katsuya, Hirano
Publikováno v:
Journal of Smooth Muscle Research. 58:50-62
Pulmonary arterial hypertension (PAH) is an intractable vascular disease characterized by a progressive increase in pulmonary vascular resistance caused by pulmonary vascular remodeling, which ultimately leads to right-sided heart failure. PAH remain
Autor:
Masayuki X. Mori, Ryo Okada, Reiko Sakaguchi, Hideharu Hase, Yuko Imai, Onur K. Polat, Satoru G. Itoh, Hisashi Okumura, Yasuo Mori, Yasushi Okamura, Ryuji Inoue
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2) regulates the activities of numerous membrane proteins, including diacylglycerol(DAG)-activated TRPC3/6/7 channels. Although PIP2 binding is known to support DAG-activated TRP channel activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43bc68a31aa33310f5cf431b80e5547e
https://doi.org/10.21203/rs.3.rs-1556516/v1
https://doi.org/10.21203/rs.3.rs-1556516/v1
Autor:
Masayuki X. Mori, Ryuji Inoue
Publikováno v:
Journal of Pharmacological Sciences, Vol 126, Iss 3, Pp 186-197 (2014)
Abstract.: Phosphoinositides(4,5)-bisphosphates [PI(4,5)P2] critically controls membrane excitability, the disruption of which leads to pathophysiological states. PI(4,5)P2 plays a primary role in regulating the conduction and gating properties of io
Externí odkaz:
https://doaj.org/article/bf22c26603684d8185c282d4579c1af0
Autor:
Kaori Koga, Tetsuhiko Go, Mikiko Aoki, Ryuji Inoue, Hiroyasu Yokomise, Aya Yamamura, Kohtaro Abe, Katsuya Hirano, Lin Hai Kurahara, Narumi Aoki-Shoi, Sei Kobayashi, Eiji Yahiro, Satoh Toru, Hiroko Kishi, Keizo Hiraishi, Zhang Bo, Kaori Ishikawa, Ying Zhang
Publikováno v:
Journal of Molecular and Cellular Cardiology. 148:50-62
Pulmonary arterial hypertension (PAH) is a multifactorial disease characterized by pulmonary arterial vasoconstriction and remodeling. Src family tyrosine kinases, including Fyn, play critical roles in vascular remodeling via the inhibition of STAT3