Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ryuichi Yagi"'
Autor:
Hiroaki Shiokawa, Ryuichi Yagi
Publikováno v:
Information Integration and Web Intelligence ISBN: 9783031210464
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::515d23d5ed1bde3fb54e1f41641f5355
https://doi.org/10.1007/978-3-031-21047-1_14
https://doi.org/10.1007/978-3-031-21047-1_14
Publikováno v:
Zairyo-to-Kankyo. 51:532-537
Autor:
Ryuichi Yagi, Yuji Ozawa, Yuichiro Yabe, Takashi Watanabe, Takahiro Shibayama, Aikichi Iwamoto, Tamayo Nitta, Eiji Takashiro, Akihiko Nakagawa, Shuichi Miyamoto, Atsushi Kasuya, Takashi Nishigaki
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:595-604
The structure-activity relationship of HIV-1 protease (HIV-1 PR) inhibitors containing AHPBA (3-amino-2-hydroxy-4-phenylbutanoic acid) is discussed. In order to solve the problem of poor oral bioavailability, small-sized dipeptide HIV-1 protease inhi
Autor:
Shinichi Oka, Yuji Ozawa, Masakatsu Kaneko, Takashi Nishigaki, Ryuichi Yagi, Satoshi Kimura, Yasuo Komatsu, Makoto Koizumi, Eiko Ohtsuka, Aikichi Iwamoto
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 17:207-218
Three ribozymes, a hairpin ribozyme (HR112) and two hammerhead ribozymes (RZ115 and RZ119) containing a 5′C(UUCG)G3′ loop were designed to cleave the U5 region in the long terminal repeat (LTR) of HIV-1 RNA. The t½ values of chemically synthesiz
Autor:
Shuichi Miyamoto, Takashi Nishigaki, Ryuichi Yagi, Hiroshi Handa, Yasuko Ishikawa, Tomoaki Komai, Atsushi Kasuya, Hisayo Suzuki-Sunagawa
Publikováno v:
Biochemical and Biophysical Research Communications. 230:557-561
In cell-free proteolytic processing using recombinant HIV-1 protease and Gag precursor polypeptide, certain simple oxim derivatives containing halogenomethylketone and phenyl moieties displayed HIV-1 protease inhibitory activity. Their Ki values rang
Autor:
Takashi Nishigaki, Ryuichi Yagi, Hiroshi Mohri, Hiroshi Handa, Hisayo Suzuki-Sunagawa, Mitsuya Sakurai, Kaoru Shimada, Higashida Susumu, Shinichi Oka, Tomoaki Komai, Akira Yasuoka, Satoshi Kimura, Yuichiro Yabe, Machiko Sugano
Publikováno v:
Biological and Pharmaceutical Bulletin. 20:175-180
In a series of compounds containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA), a transitionstate mimetic, R-87366:(2S,3S)-3-[N-(quinoxaline-2-carbonyl)-L-asparaginyl]amino- 2-hydroxy-4-phenylbutanoyl-L-proline tert-butylamide, was found
Autor:
Ichiro Hayakawa, Takahiro Shibayama, Shuichi Miyamoto, Tamayo Nitta, Ryuichi Yagi, Yuichiro Yabe, Eiji Takashiro, Akihiko Nakagawa, Ikue Yamamoto, Atsushi Kasuya, Yuji Ozawa
Publikováno v:
Bioorganicmedicinal chemistry. 7(9)
The structure–activity relationship of HIV-1 protease (HIV-1 PR) inhibitors containing α-hydroxy-β-amino acids is discussed. We demonstrated that substituent groups on the P 1 aromatic rings of the inhibitors exert significant influence on their
Autor:
Shuichi Miyamaoto, Atsushi Kasuya, A Yasuoka, Yuji Ozawa, Takashi Nishigaki, Satoshi Kimura, Yuichiro Yabe, Hiroshi Handa, Tamayo Nitta, Kaoru Shimada, Shinichi Oka, Higashida Susumu, Ryuichi Yagi, Mitsuya Sakurai, Hiroshi Mohri, Tomoaki Komai
Publikováno v:
Bioorganicmedicinal chemistry. 4(8)
Systematic replacement in the 3- or 4-position of the pyrrolidine ring at P1' proline was carried out. Compound 26, which has a Cl atom in the 4(S)-position was the most active among inhibitors substituted with other halogen atoms or other substituen
Autor:
Takashi Nishigaki, Yuichiro Yabe, Machiko Sugano, Mitsuya Sakurai, Ryuichi Yagi, Hiroshi Handa, Higashida Susumu, Yuji Ozawa, Tomoaki Komai
Publikováno v:
Bioorganicmedicinal chemistry. 2(8)
A series of Human Immunodeficiency Virus type-1 protease (HIV-1 PR) inhibitors that contain 3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA) at the scission site of the substrate were prepared and evaluated for their inhibitory activity. Preliminary s
Autor:
Takashi Nishigaki, Yuichiro Yabe, Ryuichi Yagi, Machiko Sugano, Tomoaki Komai, Mitsuya Sakurai, Higashida Susumu, Hiroshi Handa
Publikováno v:
Chemicalpharmaceutical bulletin. 42(3)
Systematic replacement of the P4-P2 subsites of substrate-based human immunodeficiency virus type 1 protease (HIV-1 PR) inhibitors containing cyclohexylalanylalanine hydroxyethylene dipeptide isostere (Cha-psi [H.E.]-Ala) at positions corresponding t