Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ryuichi Totsuka"'
Publikováno v:
The Kobe journal of medical sciences. 62(2)
VLA-1 (very late antigen-1) is implicated in recruitment, retention and activation of leukocytes and its blockade has been referred as a potential target of new drug discovery to address unmet medical needs in inflammatory disease area. In the presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5f8fbc7005391f102dc6bab241007aa
https://pubmed.ncbi.nlm.nih.gov/27578034
https://pubmed.ncbi.nlm.nih.gov/27578034
Autor:
Matsuo Kikuchi, Ryuichi Totsuka
Publikováno v:
Folia Pharmacologica Japonica. 131:115-119
気管支喘息の基本となる病態が気道の慢性炎症であることから，吸入ステロイド薬を中心とした抗炎症療法の導入は喘息症状のコントロールを可能にし，喘息患者のquality of lifeを飛躍的
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f011b76bbe09f9d5585ce525b0f737b
https://doi.org/10.1254/fpj.131.115
https://doi.org/10.1254/fpj.131.115
Autor:
Moorthy S. S. Palanki, Lynn J. Ransone, Minghuan Ren, Ryuichi Totsuka, Sonal Desai, Arnie Ow, Paul Erdman, Peter W. Tsao, Cheryl Spooner, Brydon L. Bennett, Mark J. Suto, Wataru Toriumi, Anthony M. Manning
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4077-4080
We have developed novel orally active quinazoline analogues as inhibitors of AP-1 and NF-κB mediated transcriptional activation. Among the derivatives prepared, 1-[2-(2-thienyl)quinazolin-4-ylamino]-3-methyl-3-pyrroline-2,5-dione ( 10 ) showed signi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53dea96edefc7cf5e62bc9d946524597
https://doi.org/10.1016/j.bmcl.2003.08.047
https://doi.org/10.1016/j.bmcl.2003.08.047
Publikováno v:
Japanese Journal of Pharmacology. 78:225-228
This study demonstrated the decrease of bone mineral density (BMD) in the type II collagen (CII)-induced arthritis (CIA) model in rats and the relationship between BMD and paw edema and the effect of dexamethasone-21-phosphate (DEX). The paw swelling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169878ed40b6c13d23a8b2b474810334
https://doi.org/10.1254/jjp.78.225
https://doi.org/10.1254/jjp.78.225
Publikováno v:
Clinical Immunology and Immunopathology. 84:166-170
This study demonstrates that systemic and local decreases in bone mineral density (BMD) occurred with Freund's complete adjuvant injection in the rat right footpad using dual energy X-ray absorptiometry. The rats were assigned to either adjuvant-trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c7c57a78c4c9913748b7768623ff28
https://doi.org/10.1006/clin.1997.4373
https://doi.org/10.1006/clin.1997.4373
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 16(1-2)
Cyclosporine A and steroids are effective against rheumatoid arthritis and also known as substrates of P-glycoprotein (P-gp). We investigated the effect of arthritis on the hepatic and intestinal P-gp activity in rats, and substantiated the expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d990b73dbb0747a8af3c3463d8a1f4
https://pubmed.ncbi.nlm.nih.gov/12113888
https://pubmed.ncbi.nlm.nih.gov/12113888
Publikováno v:
Bioorganicmedicinal chemistry. 5(6)
Some enediyne antitumor antibiotics induce site-selective cleavages for yeast tRNA(Phe) with three-dimensional structure. Of special interest is the fact that tRNA(Phe) is specifically cleaved at the anticodon arm regions by C-1027 and esperamicin A1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1caa3b6dff407b05a002e4b9861fda84
https://pubmed.ncbi.nlm.nih.gov/9222516
https://pubmed.ncbi.nlm.nih.gov/9222516
Autor:
Isao Takata, Toshiki Takagi, Takashi Murata, Tatsuo Suzuki, Ryuichi Totsuka, Hisako Fujimura, Yasushi Ohmachi, Peter W. Tsao
Publikováno v:
Clinical immunology and immunopathology. 83(2)
The transcription factor NF-kappa B plays a significant role in inflammatory diseases. In this study we have investigated the expression of activated NF-kappa B p65 subunit in the rat adjuvant arthritis model in a 28-day time-course experiment using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c34a9c70630d3d59a498f0ef6e337f
https://pubmed.ncbi.nlm.nih.gov/9143378
https://pubmed.ncbi.nlm.nih.gov/9143378
Autor:
Toshiki, Takagi, Peter W., Tsao, Ryuichi, Totsuka, Tatsuo, Suzuki, Takashi, Murata, Isao, Takata
Publikováno v:
In Japanese Journal of Pharmacology 1998 78(2):225-228