Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Ryuichi Shigemoto"'
Autor:
Laura E Burnett, Peter Koppensteiner, Olga Symonova, Tomás Masson, Tomas Vega-Zuniga, Ximena Contreras, Thomas Rülicke, Ryuichi Shigemoto, Gaia Novarino, Maximilian Joesch
Publikováno v:
PLoS Biology, Vol 22, Iss 6, p e3002668 (2024)
Despite the diverse genetic origins of autism spectrum disorders (ASDs), affected individuals share strikingly similar and correlated behavioural traits that include perceptual and sensory processing challenges. Notably, the severity of these sensory
Externí odkaz:
https://doaj.org/article/86714a1ab5f44238b4ba96712c0317e3
Autor:
Nicholas C. Vierra, Luisa Ribeiro-Silva, Michael Kirmiz, Deborah van der List, Pradeep Bhandari, Olivia A. Mack, James Carroll, Elodie Le Monnier, Sue A. Aicher, Ryuichi Shigemoto, James S. Trimmer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) are specialized membrane contacts ubiquitous in eukaryotic cells. Concentration of intracellular signaling machinery near ER-PM junctions allows these domains to s
Externí odkaz:
https://doaj.org/article/7f2913f73e5a47ccb468da67c35186d7
Autor:
Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruiz, Ana Esther Moreno-Martínez, Luis de la Ossa, Ester Aso, Laura Gómez-Acero, Ryuichi Shigemoto, Yugo Fukazawa, Francisco Ciruela, Rafael Luján
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Alzheimer’s disease (AD) is characterized by a reorganization of brain activity determining network hyperexcitability and loss of synaptic plasticity. Precisely, a dysfunction in metabotropic GABAB receptor signalling through G protein-gat
Externí odkaz:
https://doaj.org/article/ad403bc9036e48249c0c8a940b3435b4
Publikováno v:
Frontiers in Neuroanatomy, Vol 16 (2022)
Upon the arrival of action potentials at nerve terminals, neurotransmitters are released from synaptic vesicles (SVs) by exocytosis. CaV2.1, 2.2, and 2.3 are the major subunits of the voltage-gated calcium channel (VGCC) responsible for increasing in
Externí odkaz:
https://doaj.org/article/65ed7e758c5a4ceaa43a44da2fda089d
Autor:
Shigekazu Tabata, Marijo Jevtic, Nobutaka Kurashige, Hirokazu Fuchida, Munetsugu Kido, Kazushi Tani, Naoki Zenmyo, Shohei Uchinomiya, Harumi Harada, Makoto Itakura, Itaru Hamachi, Ryuichi Shigemoto, Akio Ojida
Publikováno v:
iScience, Vol 22, Iss , Pp 256-268 (2019)
Summary: Electron microscopy (EM) is a technology that enables visualization of single proteins at a nanometer resolution. However, current protein analysis by EM mainly relies on immunolabeling with gold-particle-conjugated antibodies, which is comp
Externí odkaz:
https://doaj.org/article/f9927222063b4dbb97cc305480dde8fb
Autor:
Celia Biane, Florian Rückerl, Therese Abrahamsson, Cécile Saint-Cloment, Jean Mariani, Ryuichi Shigemoto, David A DiGregorio, Rachel M Sherrard, Laurence Cathala
Publikováno v:
eLife, Vol 10 (2021)
Synaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental disorders. Yet how these changes influence the neuronal computations necessary for normal brain fu
Externí odkaz:
https://doaj.org/article/e901c6bb1a0b4100a07a29c39d4e8419
Autor:
Pradeep Bhandari, David Vandael, Diego Fernández-Fernández, Thorsten Fritzius, David Kleindienst, Cihan Önal, Jacqueline Montanaro, Martin Gassmann, Peter Jonas, Akos Kulik, Bernhard Bettler, Ryuichi Shigemoto, Peter Koppensteiner
Publikováno v:
eLife, Vol 10 (2021)
The synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN) is critical for emotion-related behaviors and uniquely expresses R-type Ca2+ channels (Cav2.3) and auxiliary GABAB receptor (GBR) subunits, the K+-channel tetrameriza
Externí odkaz:
https://doaj.org/article/0a37b242705b4a829d776d1abe599f5f
Autor:
Jin Bao, Michael Graupner, Guadalupe Astorga, Thibault Collin, Abdelali Jalil, Dwi Wahyu Indriati, Jonathan Bradley, Ryuichi Shigemoto, Isabel Llano
Publikováno v:
eLife, Vol 9 (2020)
Type 1 metabotropic glutamate receptors (mGluR1s) are key elements in neuronal signaling. While their function is well documented in slices, requirements for their activation in vivo are poorly understood. We examine this question in adult mice in vi
Externí odkaz:
https://doaj.org/article/7aa96142ac5742428a55ea3d89634857
Autor:
Kohgaku Eguchi, Philipp Velicky, Elena Hollergschwandtner, Makoto Itakura, Yugo Fukazawa, Johann Georg Danzl, Ryuichi Shigemoto
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Acute brain slice preparation is a powerful experimental model for investigating the characteristics of synaptic function in the brain. Although brain tissue is usually cut at ice-cold temperature (CT) to facilitate slicing and avoid neuronal damage,
Externí odkaz:
https://doaj.org/article/c600924fb9664d95874df254deea8e90
Autor:
Elisabetta Aloisi, Katy Le Corf, Julien Dupuis, Pei Zhang, Melanie Ginger, Virginie Labrousse, Michela Spatuzza, Matthias Georg Haberl, Lara Costa, Ryuichi Shigemoto, Anke Tappe-Theodor, Filippo Drago, Pier Vincenzo Piazza, Christophe Mulle, Laurent Groc, Lucia Ciranna, Maria Vincenza Catania, Andreas Frick
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Dysfunction of mGluR5 has been implicated in Fragile X syndrome. Here, using a single-molecule tracking technique, the authors found an increased lateral mobility of mGluR5 at the synaptic site in Fmr1 KO hippocampal neurons, leading to abnormal NMDA
Externí odkaz:
https://doaj.org/article/a5099cbf5e534deea4c2a121546338d3