Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ryuichi Motoda"'
Autor:
Akira Sugimoto, Ryuichi Motoda, Kunzo Orita, Ayumi Okochi, Masayoshi Kibata, Toshiya Inoue, Kazue Tsuji-Takayama, Mayuko Yamamoto, Shuji Nakamura, Motoyuki Suzuki, Akira Harashima, Takeshi Otani, Fumiyuki Yamasaki
Publikováno v:
Experimental Hematology. 35:287-296
Objective Since the existence of mouse naturally occurring CD4 + CD25 + T regulatory (Treg) cells was demonstrated, a variety of human Treg subsets have been identified as distinct T cell populations. Here we show the establishment of novel Treg cell
Autor:
Mayuko Yamamoto, Motoyuki Suzuki, Kunzo Orita, Shuji Nakamura, Akira Sugimoto, Ryuichi Motoda
Publikováno v:
Experimental Hematology. 34:1142-1149
Objective Notch receptors and their ligands are known to play an important role in hematopoietic cell fate decisions. Although expressions of Notch ligands were frequently detected in bone marrow cells or thymic epithelial cells, regulatory roles of
Autor:
Mayuko Yamamoto, Ryuichi Motoda, Kunzo Orita, Akira Sugimoto, Shuji Nakamura, Toshiya Inoue, Fumiyuki Yamasaki, Motoyuki Suzuki
Publikováno v:
Experimental Hematology. 34:424-432
Objective Important roles of Notch signaling have been demonstrated in hematopoiesis. In many cases, activation of the Notch pathway leads to the inhibition of differentiation of immature precursors, suggesting a potential role in self-renewal promot
Autor:
Akira Harashima, Hans G. Drexler, Ryuichi Motoda, Yoshinobu Matsuo, Ayumi Okochi, Mitsune Tanimoto, Kunzo Orita
Publikováno v:
Leukemia Research. 29:841-848
A number of transcription factors (TFs) have been reported that play crucial roles in hematopoiesis. However, only little is known about how these factors are involved in the mechanisms of hematopoietic development and lineage commitment. To investig
Autor:
Kazue Tsuji-Takayama, Shuji Nakamura, Yoshihiro Ijiri, Toshiya Inoue, Ryuichi Motoda, Kunzo Orita, Takeshi Otani
Publikováno v:
Biochemical and Biophysical Research Communications. 323:86-90
The de novo methylation activity is essential for embryonic development as well as embryonic stem (ES) cell differentiation, where the intensive and extensive DNA methylation was detected. In this study, we investigated the effects of a demethylating
Autor:
Toshiya Inoue, Kazue Tsuji-Takayama, Kunzo Orita, Ryuichi Motoda, Takeshi Otani, Shuji Nakamura, Yoshihiro Ijiri
Publikováno v:
Experimental Hematology. 32:607-613
Objective In this study, we analyzed murine primitive erythropoiesis by coculturing Flk-1 + ES-derived cells with OP9 to find efficient culture conditions for erythroid cell induction. We utilized a nonserum culture system and EPO (erythropoietin) an
Autor:
Akira Harashima, Tamotsu Yoshioka, Mayuko Yamamoto, Ayumi Okochi, Kunzo Orita, Motoyuki Suzuki, Yoshinobu Matsuo, Ryuichi Motoda
Publikováno v:
Experimental Hematology. 30:1132-1138
Objective Several investigators have reported that transforming growth factor (TGF)- β 1 and granulocyte-macrophage colony-stimulating factor (GM-CSF) synergistically support cell proliferation. However, the mechanisms involved have not been elucida
Autor:
Akira Harashima, Motoyuki Suzuki, Mayuko Yamamoto, Fumiyuki Yamasaki, Ayumi Okochi, Ryuichi Motoda, Shuji Nakamura, Kunzo Orita
Publikováno v:
American Journal of Hematology. 77:313-315
DNA methylation plays important roles in a wide range of biological phenomena, especially in the embryonic development and tumorigenesis. However, correlations between differentiation and DNA methylation have not been clarified well in each different
NK-355, an aminovinyl photosensitizing dye, enhances collagen production through TGF-β1 upregulation
Publikováno v:
Journal of Dermatological Science. 34:56-58
Publikováno v:
Journal of Immunological Methods. 130:25-31
Rat-mouse hybridoma cells producing anti-mouse IgE antibodies were intraperitoneally or subcutaneously inoculated into newborn or suckling hamsters receiving rabbit anti-hamster thymocyte globulin from the day of birth twice a week for at least 3 wee