Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Ryuichi KAMBAYASHI"'
Autor:
Ai Goto, Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Makoto Shinozaki, Yoshinori Takei, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 152, Iss 4, Pp 201-209 (2023)
We simultaneously assessed electropharmacological effects of anti-atrial fibrillatory drug vernakalant and its potential risk toward torsade de pointes. Vernakalant hydrochloride in doses of 0.3 and 3 mg/kg/10 min was intravenously administered to is
Externí odkaz:
https://doaj.org/article/b956d5c03fd84d6aa6002752932fa2bc
Autor:
Ryuichi Kambayashi, Ai Goto, Hiroko Izumi-Nakaseko, Ichiro Oikawa, Naoki Ikeda, Kazuki Matsuda, Yoshinori Takei, Akio Matsumoto, Yuji Kumagai, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 3, Pp 191-199 (2022)
We investigated how a lack of placebo control affects the interpretation of results of thorough QT/QTc (TQT) study. Results of TQT study in 48 healthy Japanese subjects assessing the effects of 480 and 960 mg of carotegrast methyl (test drug) and 400
Externí odkaz:
https://doaj.org/article/f7331423d2d34f96a3ee8982550b8a7f
Autor:
Koki Chiba, Ryuichi Kambayashi, Mayu Onozato, Ai Goto, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Koichiro Tanaka, Yasunari Kanda, Takeshi Fukushima, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 3, Pp 154-162 (2022)
Imatinib has been reported to induce heart failure and/or QTc prolongation. To better understand their underlying mechanisms, we assessed its effects on cardiohemodynamic, electrocardiographic and echocardiographic variables along with biomarkers of
Externí odkaz:
https://doaj.org/article/fd87e9c0826943c79c0ee21cfceafe87
Autor:
Aneesh V. Karkhanis, Gopalakrishnan Venkatesan, Ryuichi Kambayashi, Jacqueline Wen Hui Leow, Marcus Qingrui Han, Hiroko Izumi-Nakaseko, Ai Goto, Jeremy Kah Sheng Pang, Boon Seng Soh, Pipin Kojodjojo, Atsushi Sugiyama, Eric Chun Yong Chan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 10, Pp 3905-3923 (2022)
Cytochrome P4502J2 (CYP2J2) metabolizes arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug prescribed for treatment of atrial fibrillation (AF) induces cardiac adverse effects (AEs) with po
Externí odkaz:
https://doaj.org/article/e6843c2c6f2348c9b79633b11dd4d46d
Autor:
Satoshi Kawakami, Ryuichi Kambayashi, Kazuhiro Takada, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 2, Pp 67-73 (2022)
We analyzed role of cardiac α1-adrenoreceptors for the torsadogenic action of IKr blocker nifekalant in isoflurane-anesthetized atrioventricular block rabbits. Bradycardia was induced by atrioventricular node ablation, and the ventricle was electric
Externí odkaz:
https://doaj.org/article/e883ec64e945443eaffa5eabe4cb4081
Autor:
Ryuichi Kambayashi, Ai Goto, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Shinichi Kawai, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 149, Iss 4, Pp 175-178 (2022)
Since information is still limited whether atrial IK,ACh may become a potential therapeutic target to terminate persistent atrial fibrillation (AF), we assessed it by using the persistent AF canine model with representative IK,ACh inhibitor AVE0118 a
Externí odkaz:
https://doaj.org/article/fe14cffa9ba44d31a53fd6e227c8f262
Autor:
Ryuichi Kambayashi, Ai Goto, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Makoto Shinozaki, Shinichi Kawai, Akio Matsumoto, Yoshinori Takei, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 4, Pp 343-350 (2022)
Although NMDA receptor antagonist memantine is considered to be better tolerated than cholinesterase inhibitors on treating Alzheimer's disease, several types of cardiovascular adverse events have been associated with memantine treatment, including h
Externí odkaz:
https://doaj.org/article/48ebbcb6e236469c8064a6bf1f7c8dbe
Autor:
Ryuichi Kambayashi, Ai Goto, Mayu Onozato, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Shinichi Kawai, Takeshi Fukushima, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 179-186 (2022)
Since information of antiviral drug oseltamivir on the anti-atrial fibrillation (AF) property is still limited, we assessed it using the canine paroxysmal AF model. Oseltamivir in doses of 3 and 30 mg/kg/10 min was intravenously infused to the isoflu
Externí odkaz:
https://doaj.org/article/2f33f0d0210d45fd9ff92aaa89defa9c
Autor:
Hiroko Izumi-Nakaseko, Kengo Sakamoto, Ai Goto, Ryuichi Kambayashi, Akio Matsumoto, Yoshinori Takei, Akira Takahara, Atsushi Sugiyama
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
We studied time course of pathological remodeling occurring in the cynomolgus monkey hearts against persistent atrioventricular block condition (n = 10). The atrioventricular block induced the ventricular and atrial dilation followed by the ventricul
Externí odkaz:
https://doaj.org/article/a9d96779b545406e9c16603bc9cb91f9
Autor:
Hiroyuki Saito, Ryuichi Kambayashi, Ai Goto, Mihoko Hagiwara-Nagasawa, Kiyotaka Hoshiai, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Yasuki Akie, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 3, Pp 268-272 (2021)
We assessed concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables using a cross-over design in intact beagle dogs (n = 4). Elevation of inhaled halothane from 1.0% to 2.0% or isofl
Externí odkaz:
https://doaj.org/article/ef116513f3774b34b0e2f2b49449f29f