Výsledky vyhledávání - "Ryu Tominaga"

The JNK pathway modulates expression and phosphorylation of 4E-BP1 in MIN6 pancreatic β-cells under oxidative stress conditions

Autor: Chihiro Satake, Hisamitsu Ishihara, Masahiro Usui, Yoshitomo Oka, Keiichi Kondo, Yasuhiro Tanji, Suguru Yamaguchi, Hideki Katagiri, Ryu Tominaga

Publikováno v: Cell Biochemistry and Function. 28:387-393

Stress-mediated apoptosis may play a crucial role in loss of pancreatic beta-cell mass, contributing to the development of diabetes. We have recently identified that translational control involving the translational suppressor eIF4E binding protein-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a25389f37d8aa77e3a8d0a31686e516
https://doi.org/10.1002/cbf.1667

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ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

Autor: Ryu Tominaga, Jun-ichi Miyazaki, Yuichiro Munakata, Nahum Sonenberg, Akira Tamura, Takahiro Yamada, Hiroyuki Aburatani, Hisamitsu Ishihara, Yoshitomo Oka, Hideki Katagiri, Kyoko Tsukiyama-Kohara, Fumi Tashiro, Suguru Yamaguchi, Masahiro Usui, Chihiro Satake

Publikováno v: Cell Metabolism. 7(3):269-276

Endoplasmic reticulum (ER) stress-mediated apoptosis may play a crucial role in loss of pancreatic beta cell mass, contributing to the development of diabetes. Here we show that induction of 4E-BP1, the suppressor of the mRNA 5' cap-binding protein e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2be487a5d48737d88050bc1c122f065

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Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance

Autor: Suguru Yamaguchi, Yoshitomo Oka, Hisamitsu Ishihara, Masahiro Usui, Ryu Tominaga, Manabu Fukumoto, Yasushi Ishigaki, Hideki Katagiri, Yasuhiro Tanji, Kazutoshi Mori

Publikováno v: Metabolism: clinical and experimental. 61(8)

Activating transcription factor 6α (ATF6α) is essential for the endoplasmic reticulum (ER) stress response. Since recent studies suggested that ER stress is involved in the pathogenesis of type 2 diabetes mellitus, we have analyzed Atf6α-null (Atf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047d0d6dc37e8f007c5d558bc6f94f08
https://pubmed.ncbi.nlm.nih.gov/22386934

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